Contribution of impairment of cough and swallowing reflexes and silent aspiration of oropharyngeal bacteria to the mechanism of postoperative pneumonia
| Project/Area Number |
20591661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
HOSHIKAWA Yasushi Tohoku University, 加齢医学研究所, 助教 (90333814)
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| Co-Investigator(Kenkyū-buntansha) |
NODA Masafumi 東北大学, 病院, 助教 (70400356)
SADO Tetsu 東北大学, 病院, 助教 (20396485)
KONDO Takashi 東北大学, 加齢医学研究所, 教授 (10195901)
SATO Takuichi 東北大学, 歯学研究科, 講師 (10303132)
丹田 奈緒子 東北大学, 病院, 助教 (00422121)
松田 安史 東北大学, 病院, 特任助教 (00455833)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Nobuhiro 東北大学, 歯学研究科, 教授 (60183852)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 呼吸器外科学 / 肺切除術後肺炎 / 上気道防御反射(咳・嚥下反射) / 口腔内常在菌 / 下顕性誤嚥 / 口腔ケア / 高齢者 / 嫌気培養 / 16S rRNA PCR-Seuence法 / 不顕性誤嚥 / 嫌気塔養 / 16S rRNA PCR-Sequence法 / 16S rRNA PCR-Sequencc法 |
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| Research Abstract |
This study reconfirmed the close relevance of impairment of cough and swallowing reflexes to postoperative pneumonia after lung resection. We showed the bronchial fluid from patients developing postoperative pneumonia contained considerable oral anaerobic bacteria, by using oral biochemical technique. Our intensive perioperative oral care program, including professional assessment of oral status, dental cleaning, and patient education for self-oral care by a dentist, followed by intensive oral care at least 3 times a day by ICU nurses, and encouragement of self-oral care by floor nurses, tended to decrease anaerobic bacterial amounts in the bronchial fluid and prevented the incidence of postoperative pneumonia.
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Report
(4 results)
Research Products
(7 results)
