Asbestos fiber concentration in lung tissues and mutation analysis of malignant pleural mesothelioma
| Project/Area Number |
20591665
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
YOKOI Kohei Nagoya University, 医学系研究科, 准教授 (60378007)
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| Co-Investigator(Kenkyū-buntansha) |
USAMI Noriyasu 名古屋大学, 医学部附属病院, 助教 (30378179)
TANIGUCHI Tetsuo 名古屋大学, 医学部附属病院, 病院助教 (20378186)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 悪性胸膜中皮腫 / アスベスト / 遺伝子変異 / 癌遺伝子 / 癌抑制遺伝子 / 肺内アスベスト濃度 |
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| Research Abstract |
We established twelve malignant pleural mesothelioma(MPM) cell lines from Japanese patients. We detected homozygous deletion of p16^<INK4A>/p14^<ARF> in all MPM cell lines. However, mutations of other tumor suppressor genes, including TP53, and protooncogenes, including KRAS, NRAS, BRAF, EGFR and HER2, were not found in these cell lines. Two women who had no history of asbestos exposure showed lower concentrations of crysotile and amphibole asbestos than the control subject. On the other hand, most patients with a history of asbestos exposure had higher concentrations of crysotile and amphibole asbestos than the control subject, but even in some patients with a history of asbestos exposure the low concentrations were observed. To elucidate the relation between the pulmonary asbestos fiber concentrations by fiber types and development of MPM, further investigations are necessary.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Phase II study of carboplatin and gemcitabine as adjuvant chemotherapy in patients with completely resected non-small cell lung cancer : a report from the Central Japan Lung Study Group, CJLSG 0503 trial.2010
Author(s)
Usami N, Yokoi K, Hasegawa Y, Taniguchi H, Shindo J, Yamamoto M, Suzuki R, Tmaizumi K, Kondo M, Shimokata K.
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Journal Title
Int J Clin Oncol 15
Pages: 583-587
NAID
Related Report
Peer Reviewed
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[Journal Article] Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells.2009
Author(s)
Kawaguchi K, Murakami H, Taniguchi T, Fujii M, Kawata S, Fukui T, Kondo Y, Osada H, Usami N, Yokoi K, Ueda Y, Yatabe Y, Ito M, Horio Y, Mida T, Sekido Y.
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Journal Title
Carcinogenesis 30
Pages: 1097-1105
Related Report
Peer Reviewed
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[Journal Article] Multimodality therapy for patients with invasive thymoma disseminated into the pleural cavity : the potential role of extrapleural pneumonectomy.2009
Author(s)
Ishikawa Y, Matsuguma H, Nakahara R, Suzuki H, Ui A, Kondo T, Kamiyama Y, Igarashi S, Mori K, Kodama T, Yokoi K.
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Journal Title
Ann Thorac Surg 88
Pages: 952-957
Related Report
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