| Project/Area Number |
20591668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
BANDO Toru Kyoto University, 大学院・医学研究科, 准教授 (20293954)
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| Co-Investigator(Kenkyū-buntansha) |
DATE Hiroshi 京都大学, 大学院・医学研究科, 教授 (60252962)
SHOJI Tsuyoshi 京都大学, 大学院・医学研究科, 助教 (80402840)
FUJINAGA Takuji 京都大学, 大学院・医学研究科, 助教 (00444456)
CHEN Fengshi 京都大学, 大学院・医学研究科, 助教 (00452334)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 外科 / 移植・再生医療 / トランスレーショナルリサーチ |
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| Research Abstract |
We evaluated post-transplant pulmonary function of the lung graft that received 4-hour warm ischemia.in a canine left lung transplantation model. One hour mechanical ventilation with 100% oxygen during the last hour of 4-hour warm ischemia provided significantly better lung function after reperfusion than no ventilation. In the next experiment where we extended the warm ischemic time to 5 hours, the last one-hour ventilation with inhalation of a beta2-adrenoreceptor agonist (Procatelol) significantly enhanced the posttransplant lung performance than the one-hour ventilation only. We demonstrated the efficacy and safety of the combined therapy with inhalation of a beta2-agonist and mechanical ventilation for the lungs from donor after cardiac death.
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