Immunological function of thymoma in terms of interaction between T cells and neoplastic epithelial cells

• Project/Area Number: 20591669
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Osaka University
• Principal Investigator: KADOTA Yosihisa Osaka University, 医学系研究科, 助教 (50464243)
• Co-Investigator(Kenkyū-buntansha): OKUMURA Meinosin 大阪大学, 医学系研究科, 教授 (40252647) ; INOUE Masayosi 大阪大学, 医学系研究科, 講師 (10379232) ; MINAMI Masato 大阪大学, 医学部附属病院, 准教授 (10240847) ; UTUMI Tomoki 大阪大学, 医学系研究科, 助教 (40423165)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 胸腺腫 / 重症筋無力症 / 胸腺微小環境 / TH-POK / AIRE

Research Abstract

Thymoma is known to associate with autoimmune diseases. Thymoma derived T cells were thought plausible to investigate the pathogenesis of thymoma associated autoimmunity. In this study we investigate the development of thymoma T cell in terms of its lineage-commitment and its exportation to the peripheral blood. Our results suggested that Th-POK and Runx3 expression of T cell in thymoma could have key roles in the lineage commitment.

Research Products

• [Journal Article] Regulation of Th-POK and Runx3 in T cell development in human thymoma. (2009)
  • Author(s): Tokunaga T, Hayashi A, Kadota Y, Shiono H, Inoue M, Sawabata N, Okumura M.
  • Journal Title: Autoimmunity 42(8) Pages: 653-660