The role of cancer-host interaction in the invasion of lung adenocarcinoma

• Project/Area Number: 20591670
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kobe University
• Principal Investigator: MANIWA Yoshimasa Kobe University, 大学院・医学研究科, 講師 (50362778)
• Co-Investigator(Kenkyū-buntansha): HAYASHI Yoshitake 神戸大学, 大学院・保健学研究科, 教授 (50189669)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 呼吸器外科学 / 肺癌 / 浸潤 / 癌宿主相互作用 / 線維芽細 / 線維芽細胞

Research Abstract

A total of 63 surgically resected primary pulmonary adenocarcinoma tissues were investigated by immunohistochemistry for the expression of Necl-5. The overexpression of Necl-5 by cancer cells was significantly associated with lymph node metastasis, TNM staging and the bronchioloalveolar carcinoma ratio of tumors. Furthermore, the disease-free survival rate in patients with positive Necl-5 overexpression was significantly lower than that in patients with negative Necl-5 overexpression. These results indicate that Necl-5 plays a role in mediating tumor cell invasion and that the overexpression of Necl-5 in cancer cells has clinical significance for prognostic evaluation of patients with primary pulmonary adenocarcinoma.

Research Products

• [Journal Article] Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma. (2010)
  • Author(s): Nakai R, Maniwa Y, Tanaka Y, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Satoh N, Ogita H, Takai Y, Hayashi Y
  • Journal Title: Cancer Sci 101 Pages: 1326-1330
  • NAID: 10026592945
  • Peer Reviewed
• [Journal Article] Non-synonymous SNPs in DNA damage repair pathways and lung cancer risk. (2010)
  • Author(s): Tanaka Y, Maniwa Y, Bermudez VP, Doi T, Nishio W, Ohbayashi C, Okita Y, Hurwitz J, Hayashi Y, Yoshimura M.
  • Journal Title: Cancer 116 Pages: 896-902
  • Peer Reviewed
• [Journal Article] Chemosensitivity of Lung Cancer : Differences between Primary Tumor and Lymph Node Metastasis. (2010)
  • Author(s): Maniwa Y, Yoshimura M, Hashimoto S, Takata M, Nishio W.
  • Journal Title: Oncology Letters. 1 Pages: 345-349
  • Peer Reviewed
• [Journal Article] The cytological characteristics of small cell change of dysplasia in small hepatic nodules. (2010)
  • Author(s): Chang O, Yano Y, Masuzawa A, Fukushima N, Teramura K, Hayashi Y.
  • Journal Title: Oncol Rep 23 Pages: 1229-1232
  • Peer Reviewed
• [Journal Article] Clinical significance of hepatitis B virus-DNA in hepatocellular carcinoma negative for hepatitis B virus surface antigen. (2010)
  • Author(s): Tateiwa S, Yano Y, Seo Y, Miki A, Kawano Y, Azuma T, Hayashi Y.
  • Journal Title: Exper Therapeutic Med 1 Pages: 343-346
  • Peer Reviewed
• [Journal Article] Non-synonymous SNPs in DNA damage repair pathways and lung cancer risk (2010)
  • Author(s): Maniwa Y., et al.
  • Journal Title: Cancer Volume: 116 Pages: 896-902
  • Peer Reviewed
• [Journal Article] Chemosensitivity of Lung Cancer : Differences between Primary Tumor and Lymph Node Metastasis (2010)
  • Author(s): Maniwa Y., et al.
  • Journal Title: Oncology Letters Volume: 1 Pages: 345-349
  • Peer Reviewed
• [Journal Article] Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma (2010)
  • Author(s): Maniwa Y., et al.
  • Journal Title: Cancer Sci Volume: 101 Pages: 1326-1330
  • NAID: 10026592945
  • Peer Reviewed
• [Journal Article] Chemosensitivity of Lung Cancer : Differences between Primary Tumor and Lymph Node Metastasis (2010)
  • Author(s): Maniwa Y, et al.
  • Journal Title: Oncology Letters 1 Pages: 345-349
  • Peer Reviewed
• [Journal Article] Expression and localization of FOXO1 in non-small cell lung cancer. (2009)
  • Author(s): Maekawa T, Maniwa Y, Doi T, Okada K, Nishio W, Yoshimura M, Ohbayashi C, Hayashi Y, Okita Y.
  • Journal Title: Oncol Rep 22 Pages: 57-64
  • Peer Reviewed
• [Journal Article] Expression and localization of FOXO1 in non-small cell lung cancer (2009)
  • Author(s): Maniwa Y, et al.
  • Journal Title: Oncol Rep 22 Pages: 57-64
  • Peer Reviewed
• [Journal Article] Non-synonymous SNPs in DNA damage repair pathways and lung cancer risk (2009)
  • Author(s): Maniwa Y, et al.
  • Journal Title: Cancer 116 Pages: 896-902
  • Peer Reviewed
• [Journal Article] DNA damage sensor protein hRad9-a novel molecular target for lung cancer treatment (2008)
  • Author(s): Maniwa Y, et al
  • Journal Title: Oncol Rep 20 Pages: 1047-1052
  • Peer Reviewed
• [Journal Article] The optimal timing to resect pulmonary metastasis (2008)
  • Author(s): Maniwa Y, et al
  • Journal Title: Eur J Cardiothorac Sure 33 Pages: 1135-1138
  • Peer Reviewed
• [Journal Article] Effective chemotherapy based on chemosensitivity test for malignant pleurnl mesothelioma (2008)
  • Author(s): Maniwa Y, et al
  • Journal Title: Ann Thorac Cardiovasc Sure 14 Pages: 319-321
  • Peer Reviewed
• [Journal Article] Application of hRad9 to lung cancer treatment as a molecular marker and a molecular target.
  • Author(s): Maniwa Y, Nishio W, Yoshimura M.
  • Journal Title: Thoracic Cancer in press.
  • Peer Reviewed
• [Journal Article] MT1-MMP plays an important role in an invasive activity of malignant pleural mesothelioma cell.
  • Author(s): Doi T, Maniwa Y, Tanaka Y, Tane S, Hashimoto S, Ohno Y, Nishio W, Nishimura Y., Ohbayashi C, Okita Y, Hayashi Y, Yoshimura M.
  • Journal Title: Exp Mol Pathol in press
  • Peer Reviewed
• [Presentation] The role of Cancer-stroma interaction for invasion of Lung adenocarcinoma cell (2010)
  • Author(s): Maniwa Y.
  • Organizer: CHEST2010
  • Place of Presentation: バンクーバー、カナダ
  • Year and Date: 2010-10-30
• [Presentation] (2010)
  • Organizer: 第27回日本呼吸器外科学会総会
• [Presentation] (2010)
  • Organizer: CHEST2010(USA)
• [Presentation] DNA damage sensor protein hRad9-A novel molecular target for lung cancer treatment (2009)
  • Author(s): Maniwa Y, et al.
  • Organizer: 14th World Congress on Advances in Oncology
  • Place of Presentation: ロートラキ・ギリシャ
  • Year and Date: 2009-10-15
• [Presentation] 悪性胸膜中皮腫の外科治療 : 手術成績と今後の戦略 (2008)
  • Author(s): 眞庭 謙昌
  • Organizer: 第61回日本胸部外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2008-10-12