A examination of KGF seat to prevent bronchpleural fistula.

• Project/Area Number: 20591673
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Nagasaki University
• Principal Investigator: NAGAYASU Takeshi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80284686)
• Co-Investigator(Kenkyū-buntansha): YAMAZAKI Naoya 長崎大学, 医学部・歯学部付属病院, 講師 (70404217) ; TUCHIYA Tomoshi 長崎大学, 医学部・歯学部付属病院, 講師 (30437884) ; YANO Hiroshi 長崎大学, 医学部・歯学部付属病院, 講師 (50380887) ; 田川 努 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (20363492)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: KGF / 気管軟骨 / 創傷治癒 / 代償性肺肥大 / 肺移植 / 人工気管

Research Abstract

Local administration of KGF to trachea wound could not enhance the healing of trachea cartilage. On the other hand, intratraheal administration of KGF enhanced pulmonary epithelial proliferation in post-trilobectomy rat lung. Intratracheal administration of KGF in the remaining lung significantly augmented PCNA of alveolar cell. High dose single injection and low dose daily injection were so effective. Our results implicate that Intratracheal administration of KGF significantly augmented lung epithelial proliferation in compensatory growth in the remaining lung after trilobectomy in rats.