| Project/Area Number |
20591674
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
TSUCHIYA Tomoshi Nagasaki University, 病院, 講師 (30437884)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAYASU Takeshi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80284686)
SHIMOKAWA Isao 長崎大学, 大学院・医歯薬学総合研究科, 教授 (70187475)
TAGAWA Tsutomu 長崎大学, 大学院・医歯薬学総合研究科, 講師 (20363492)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGAMI Yoshikazu 東京理科大学, 薬学部, 教授 (90253640)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | アディポネクチン / リポポリサッカライド / 小胞体ストレス / 肺気腫 / 肺癌 / マイクロアレイ |
|---|
| Research Abstract |
In order to find out the effect of adiponectin on lung cancer and lung disease, we made elastase inhalation model, VEGF receptor blocker model, and LPS administration model. However obvious inhivitive effects were not observed. In the subcutaneous lung cancer cell injection model, the regular diet group of Tg mice showed increase tumor size and weight. Because the size of adipocytes were small and mRNA expressions of p21 and p16 and protein expressions of p21 and p53 were suppressed in adipose tissue of Tg mice, we presume the tissues of Tg mice are kept homeostasis in "young", which might induce cancer growth in adipose tissue.
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