| Project/Area Number |
20591676
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
|
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| Research Institution | Kitasato University |
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Principal Investigator |
SATOH Yukitoshi Kitasato University, 医学部, 教授 (90321637)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AMANO Hideki 北里大学, 医学部, 助教 (60296481)
ISHIKAWA YUICHI (財)癌研究会, がん研究所, 部長 (80222975)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 肺癌 / 腺癌 / 微乳頭構造 / 免疫組織化学 / 血管新生因子 / 微乳頭腺構造 / 微小乳頭腺癌 / 浸潤 / 転移 / 骨髄細胞 / EP3 |
|---|
| Research Abstract |
To analyze the relationship between lung adenocarcinomas with micropapillary pattern (MPP) and vascular endothelial growth factors (VEGF), 517 cases of resected lung cancers were collected and clinic-pathologic study was performed. MPP- positive lung cancers revealed poor prognosis, frequent vascular invasion, and frequent lymph node metastasis. Immunohistochemically, VEGF-C and R3 strongly expressed in MPP portions. By the analysis on mice models, it was considered that VEGFR-1 and 2 plays an important role in tumor progression on the stromal tissue.
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