Analysis on invasion and metastasis of lung adenocarcinomas with micropapillary pattern.

• Project/Area Number: 20591676
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kitasato University
• Principal Investigator: SATOH Yukitoshi Kitasato University, 医学部, 教授 (90321637)
• Co-Investigator(Kenkyū-buntansha): AMANO Hideki 北里大学, 医学部, 助教 (60296481) ; ISHIKAWA YUICHI (財)癌研究会, がん研究所, 部長 (80222975)
• Project Period (FY): 2008 – 2010
• Project Status: Completed(Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost : ¥3,600,000、Indirect Cost : ¥1,080,000); Fiscal Year 2010 : ¥1,170,000 (Direct Cost : ¥900,000、Indirect Cost : ¥270,000); Fiscal Year 2009 : ¥1,820,000 (Direct Cost : ¥1,400,000、Indirect Cost : ¥420,000); Fiscal Year 2008 : ¥1,690,000 (Direct Cost : ¥1,300,000、Indirect Cost : ¥390,000)
• Keywords: 肺癌 / 腺癌 / 微乳頭構造 / 免疫組織化学 / 血管新生因子 / 微乳頭腺構造 / 微小乳頭腺癌 / 浸潤 / 転移 / 骨髄細胞 / EP3

Research Abstract

To analyze the relationship between lung adenocarcinomas with micropapillary pattern (MPP) and vascular endothelial growth factors (VEGF), 517 cases of resected lung cancers were collected and clinic-pathologic study was performed. MPP- positive lung cancers revealed poor prognosis, frequent vascular invasion, and frequent lymph node metastasis. Immunohistochemically, VEGF-C and R3 strongly expressed in MPP portions. By the analysis on mice models, it was considered that VEGFR-1 and 2 plays an important role in tumor progression on the stromal tissue.

Research Products

• [Journal Article] Discriminant Model for Cytologic Distinction of Large Cell Neuroendocrine Carcinoma from Small Cell Carcinoma of the Lung (2010)
  • Author(s): Hoshi R, Furuta N, Horai T, Ishikawa Y, Miyata S, Satoh Y
  • Journal Title: J Thorac Oncol 5巻 Pages : 472-478
  • Peer Reviewed
• [Journal Article] Combined Effect of Anti-Angiogentic Agents, Angiotensin Type 1 Receptor Antagonists and Radiation Therapy. (2010)
  • Author(s): Amano H, Ohnuma Y, Niibe Y, Hayakawa K, Satoh Y, Majima M
  • Journal Title: Current Signal Transduction Therapy 5巻 Pages : 206-211
  • Peer Reviewed
• [Journal Article] Discriminant Model for Cytologic Distinction of Large Cell Neuroendocrine Carcinoma from Small Cell Carcinoma of the Lung. (2010)
  • Author(s): Hoshi Rira, Satoh Yukitoshi, et al.
  • Journal Title: J Thorac Oncol Volume : 5 Pages : 472-478
• [Journal Article] Role of insulin-like growth factor binding proteins 2 in lung adenocarcinoma : IGF independent anti-apoptotic effect via caspase-3. (2010)
  • Author(s): Migita Toshiro, Satoh Yukitoshi, et al.
  • Journal Title: Am J Pathol Volume : 176 Pages : 1756-1766
• [Journal Article] Expression of RACK1 is a novel biomarker in pulmonary adenocarcinomas. (2010)
  • Author(s): Nagashio Ryo, Satoh Yukitoshi, et al.
  • Journal Title: Lung Cancer Volume : 69 Pages : 54-59
  • Peer Reviewed
• [Journal Article] Impact of positive pleural lavage cytology on survival in patients having lung resection for non-small-cell lung cancer : An international individual patient data meta-analysis. (2010)
  • Author(s): Lim Eric, Satoh Yukitoshi, et al.
  • Journal Title: J Thorac Cardiovasc Surg Volume : 139 Pages : 1441-1446
  • Peer Reviewed
• [Journal Article] Activation status of receptor tyrosine kinase downstream pathways in primary lung adenocarcinoma with reference of KRAS and EGFR mutations. (2010)
  • Author(s): Hiramatsu Miyako, Satoh Yukitoshi, et al.
  • Journal Title: Lung Cancer Volume : 70 Pages : 94-102
  • Peer Reviewed
• [Journal Article] Combined Effect of Anti-Angiogentic Agents, Angiotensin Type 1 Receptor Antagonists and Radiation Therapy. (2010)
  • Author(s): Amano Hideki, Satoh Yukitoshi, et al.
  • Journal Title: Current Signal Transduction Therapy Volume : 5 Pages : 206-211
  • Peer Reviewed
• [Journal Article] Roles of a Prostaglandin E type Receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis (2009)
  • Author(s): Amano H, Ito Y, Suzuki T, Katoh S, Senior R, Kitasato H, Hayash I, Satoh Y, Narumiya S, Majima M
  • Journal Title: Cancer Sci 100巻 Pages : 2318-2324
  • Peer Reviewed
• [Journal Article] Association of Cytologic Micropapillary Clusters in Cytology Samples with Lymphatic Spread in Clinical Stage I Lung Adenocarcinomas (2009)
  • Author(s): Satoh Y, Hoshi R, Horai T, Okumura S, Nakagawa K, Ishikawa Y, Miyata S
  • Journal Title: Lung Cancer 64巻 Pages : 277-281
  • Peer Reviewed
• [Journal Article] Association of cytologic micropapillary clusters in cytology samples with lymphatic spread in clinical stage I lung adenocarcinomas. (2009)
  • Author(s): Satoh Y., et al.
  • Journal Title: Lung Cancer 64 Pages : 277-281
  • Peer Reviewed
• [Journal Article] Clinical Report on a Computer-controlled Hand-actuated Stapling System for General Lung Surgery : the First Application in Japan. (2009)
  • Author(s): Satoh Y., et al.
  • Journal Title: Gen Thorac Cardiovasc Surg 57 Pages : 402-405
  • Peer Reviewed
• [Journal Article] Correlation between morphology and EGFR mutations in lung adenocarcinomas. Significance of the micropapillary pattern and the hobnail cell type. (2009)
  • Author(s): Ninomiya H.Satoh Y., et al.
  • Journal Title: Lung Cancer 63 Pages : 235-240
  • Peer Reviewed
• [Journal Article] 予後因子に基づいた肺癌術後の効果的なfollow-up. (2009)
  • Author(s): 根津賢治司, 佐藤之俊
  • Journal Title: 外科治療 100 Pages : 264-270
• [Journal Article] Association of cytologic micropapillary clusters in cytology samples with lymphatic spread in clinical stage I lung adenocarcinomas. (2008)
  • Author(s): Satoh Y., et al.
  • Journal Title: Lung Cancer (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] 肺癌と細胞診 (2008)
  • Author(s): 佐藤之俊
  • Journal Title: 呼吸 27 Pages : 1115-1116
• [Journal Article] Recurrence Pattern and Rapid Intraoperative Detection of Carcinoembryonic Antigen(CEA) mRNA in Pleural Lavage in Patients with Non-Small Cell Lung Cancer(NSCLC). (2008)
  • Author(s): Sugai S, Satoh Y., et al.
  • Journal Title: Rinsyo Byori 56 Pages : 581-587
  • Peer Reviewed
• [Presentation] 原発性肺癌における細胞診での予後の推測に関する検討 (2010)
  • Author(s): 星利良,宝来威,文敏景,坂尾幸則,奥村栄,中川健,堀池篤,大柳文義,西尾誠人,元井紀子,石川雄一,宮田敏,佐藤之俊
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-11-03
• [Presentation] 原発性非小細胞肺癌における血中循環腫瘍細胞の高感度検出法の意義 (2010)
  • Author(s): 佐藤之俊
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島国際会議場(広島県)
  • Year and Date: 2010-11-03
• [Presentation] 肺癌診療における細胞診 (2010)
  • Author(s): 佐藤之俊
  • Organizer: 平成22年度山形県成人病検診従事者講習会
  • Place of Presentation: 日本海総合病院(山形県)
  • Year and Date: 2010-10-16
• [Presentation] 特別講演 肺癌診療における呼吸器細胞診:現状と展望 (2010)
  • Author(s): 佐藤之俊
  • Organizer: 第27回日本臨床細胞学会北陸支部連合会学術集会
  • Place of Presentation: 福井
  • Year and Date: 2010-09-23
• [Presentation] 肺癌診療における呼吸器細胞診:現状と展望 (2010)
  • Author(s): 佐藤之俊
  • Organizer: 第27回日本臨床細胞学会北陸支部連合会学術集会
  • Place of Presentation: 福井県済生会病院(福井県)
  • Year and Date: 2010-09-23
• [Presentation] Role of Angiotensin type 1a receptor signaling on tumor metastasis formation. (2010)
  • Author(s): Amano H, Ito Y,Matsui Y, Ogawa F, Kuroudu N, Nezu N, Iyoda A, Majima M, Satoh Y
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] 命を奪うがん細胞をみつめてみよう(もっと知りたい、肺がん最前線) (2010)
  • Author(s): 佐藤之俊
  • Organizer: 第24回日本臨床細胞学会関東連合学術集会市民公開講座
  • Place of Presentation: 軽井沢プリンスホテル(長野県)
  • Year and Date: 2010-09-18
• [Presentation] 肺癌の診断・治療と細胞診 (2010)
  • Author(s): 佐藤之俊
  • Organizer: 平成22年度第1回肺がん検診従事者講習会
  • Place of Presentation: がん検診センター(東京都)
  • Year and Date: 2010-09-17
• [Presentation] Angiogenesis enhanced by TP signaling- mediated platelet adhesion to neovasculized endothelial cells with VEGFR1+CXCR4 mobilization during hindlimb ischemia. (2010)
  • Author(s): Amano H, Kato S, Ito Y, Satoh Y, Majima M
  • Organizer: 9th World Congress for Microcirculation.
  • Place of Presentation: Paris
  • Year and Date: 2010-09-08
• [Presentation] Cytology of adenocarcinoma of the lung : peripheral non-invasive lesions and impact of micropapillary clusters on lung cancer treatment. (2010)
  • Author(s): Satoh Y, Hoshi R, Horai T, Okumura S, Nakagawa K, Ishikawa Y, Miyata S
  • Organizer: 17th International Congress of Cytology
  • Place of Presentation: Edinburgh, Scotland, UK
  • Year and Date: 2010-05-19
• [Presentation] Circulating tumor cells in peripheral venous blood of primary lung cancer patients : detection using adenovirus GFP-labeling (2010)
  • Author(s): Satoh Yukitoshi
  • Organizer: American Association for Cancer Research 101st
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2010-04-19
• [Presentation] Role of thromboxane A2-TP signaling in tumor growth and metastasis. (2009)
  • Author(s): Amano H., et al.
  • Organizer: The 9th world congerss on inflammation
  • Place of Presentation: 新宿京王プラザホテル(東京)
  • Year and Date: 2009-07-08
• [Presentation] 肺癌の診断と治療 (2009)
  • Author(s): 佐藤之俊
  • Organizer: 第24回日本臨床細胞学会山梨県支部総会・学術集会
  • Place of Presentation: 甲府
  • Year and Date: 2009-02-07
• [Book] 癌診療指針のための病理診断プラクティス 肺癌(青笹克之,松原修 編集)(細胞診断) (2011)
  • Author(s): 柿沼廣邦,佐藤之俊
  • Publisher: 中山書店 東京
• [Book] 医用画像ハンドブック(石田隆行,桂川茂彦,藤田広志 監修 第9編 さまざまな医用画像.第8章 細胞診) (2010)
  • Author(s): 柿沼廣邦,佐藤之俊
  • Publisher: オーム社,東京
• [Book] 医用画像ハンドブック (第9編 さまざまな医用画像.第8章細胞診) (2010)
  • Author(s): 柿沼廣邦
  • Publisher: オーム社
• [Remarks]
  • URL: http://www.khp.kitasato-u.ac.jp/ska/kokyukig/index.html
• [Remarks]
  • URL: http://www.khp.kitasato-u.ac.jp/ska/kokyukig/index.html