Analysis of Benefit of carotid endarterectomy by mathematical model

• Project/Area Number: 20591682
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Gunma University
• Principal Investigator: YOSHIMOTO Yuhei Gunma University, 大学院・医学系研究科, 教授 (50242061)
• Co-Investigator(Kenkyū-buntansha): NAGAKI Tomohoto 群馬大学, 医学部, 助教 (70400760)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 頚動脈内膜剥離術 / マルコフモデル

Research Abstract

We constructed a Markov model to evaluate effectiveness of carotid endaterectomy (CEA). In modeling four health states, probabilities of transition to another state were estimated using data from major randomized control trials. CEA for severe carotid stenosis would consistently and significantly benefit patients with recent symptoms. However, surgery for asymptomatic stenosis appears justified only in carefully selected conditions : low treatment risks for relatively young individuals without any comorbidities.

Research Products

• [Journal Article] Epileptogenic ganglioglioma with hypermetabolism on positron emission tomography with Fluorine-18 Fluorodeoxyglucose. (2010)
  • Author(s): Ibe Y, Takahashi A, Ishiuchi S, Hirato M, Yoshimoto Y, Yuhara Y, Sasaki A
  • Journal Title: Epilepsy and Seizure 3 Pages: 125-130
  • Peer Reviewed
• [Journal Article] Clinicopathological feature of pilomyxoid astrocytoma : three case reports. (2010)
  • Author(s): Nagaishi M, Yokoo H, Hirato J, Yoshimoto Y, Nakazato Y
  • Journal Title: Neuropathology (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity. (2010)
  • Author(s): Kubota C, Torii S, Hou N, Saito N, Yoshimoto Y, Imai H, Takeuchi T
  • Journal Title: J Biol Chem 285 Pages: 667-674
  • Peer Reviewed
• [Journal Article] Solitary intraosseous neurofibroma of the frontal bone. (2010)
  • Author(s): Yamaguchi R, Yoshida T, Nakazato Y, Yoshimoto Y
  • Journal Title: Neurol Med Chir 50 Pages: 683-686
  • Peer Reviewed
• [Journal Article] Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity. (2010)
  • Author(s): Kubota C, Torii S, Hou N, Saito N, Yoshimoto Y, Imai H, Takeuchi T
  • Journal Title: J Biol Chem Volume: 285 Pages: 667-674
  • Peer Reviewed
• [Journal Article] Solitary intraosseous neurofibroma of the frontal bone. (2010)
  • Author(s): Yamaguchi R, Yoshida T, Nakazato Y, Yoshimoto Y
  • Journal Title: Neurol Med Chir Volume: 50 Pages: 683-686
  • Peer Reviewed
• [Journal Article] Experimental investigation of encephalo-myo-synangiosis using gyrencephalic brain of the miniature pig : histopathological evaluation of dynamic reconstruction of vessels for functional anastomosis. (2009)
  • Author(s): Nakamura M, Imai H, Konno K, Kubota C, Seki K, Puentes S, Faried A, Yokoo H, Hata H, Yoshimoto Y, Saito N
  • Journal Title: J Neurosurg : Pediatrics 3 Pages: 488-495
  • Peer Reviewed
• [Journal Article] Benefit of carotid endarterectomy for symptomatic and asymptomatic severe carotid stenosis : a Markov model based on the randomized control trials. (2009)
  • Author(s): Nagaki T, Sato K, Yoshida T, Yoshimoto Y
  • Journal Title: J Neurosurg 111 Pages: 970-977
  • Peer Reviewed
• [Journal Article] Stent placement for the treatment of intracranial vertebral artery dissecting aneurysms. (2009)
  • Author(s): Miyamoto N, Naito I, Takatama S, Shimizu T, Iwai T, Shimaguchi H, Yoshimoto Y
  • Journal Title: Surgery for Cerebral Stroke 37 Pages: 184-191
  • NAID: 10025951202
  • Peer Reviewed
• [Journal Article] Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid-induced migration by isoproterenol in glioma cells. (2009)
  • Author(s): Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F
  • Journal Title: Mol Biol Cell 20 Pages: 5156-5165
  • Peer Reviewed
• [Journal Article] SIP2 receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN. (2008)
  • Author(s): Malchinkhuu E, Sato K, Maehama T, Mogi C, Tomura H, Ishiuchi S, Yoshimoto Y, Kurose H, Okajima F
  • Journal Title: Biochem Biophys Res Com 366 Pages: 963-968
  • Peer Reviewed
• [Journal Article] Biologic heterogeneity and length-biased sampling in asymptomatic neurosurgical patients. (2008)
  • Author(s): Yoshimoto Y, Tanaka Y
  • Journal Title: Br J Neurosurg 22 Pages: 368-372
  • Peer Reviewed
• [Journal Article] Experimental model of lacunar infarction in the gyrencephalic brain of the miniature pig : neurological assessment and histological, immunohistochemical, and physiological evaluation of dynamic corticospinal tract deformation. (2008)
  • Author(s): Tanaka Y, Imai H, Konno K, Miyagishima T, Kubota C, Sandra P, Aoki T, Hata H, Yoshimoto Y, Saito N
  • Journal Title: Stroke 39 Pages: 205-212
  • Peer Reviewed
• [Journal Article] Diffuse pachymeningeal hyperintensity and subdural effusion/hematoma detected by fluid-attenuated inversion recovery MR Imaging in patients with spontaneous intracranial hypertension. (2008)
  • Author(s): Tosaka M, Sato N, Fujimaki H, Tanaka Y, Kagoshima K, Takahashi A, Saito N, Yoshimoto Y
  • Journal Title: AJNR 29 Pages: 1164-1170
  • Peer Reviewed
• [Journal Article] Acute basilar artery occlusion in a patient with left subclavian artery occlusion due to first rib anomaly. (2008)
  • Author(s): Yamaguchi R, Kohga H, Kurosaki M, Tamura M, Tanaka S, Tosaka M, Yoshimoto Y
  • Journal Title: Neurol Med Chir 48 Pages: 355-359
  • Peer Reviewed
• [Journal Article] Diffuse pachymeningeal hyperintensity and subdural effusion/hematoma detected by fluid-attenuated inversion recovery MR Imaging in patients with spontaneous intracranial hypertension (2008)
  • Author(s): Tosaka M, Sato N, Fujimaki H, Tanaka Y, Kagoshima K, Takahashi A, Saito N, Yoshimoto Y
  • Journal Title: AJNR 29 Pages: 1164-1170
  • Peer Reviewed
• [Journal Article] Acute basilar artery occlusion in a patient with left subclavian artery occlusion due to firstrib anomaly (2008)
  • Author(s): Yamaguchi R, Kohga H, Kurosaki M, Tamura M, Tanaka S, Tosaka M. Yoshimoto Y
  • Journal Title: Neurol Med Chir 48 Pages: 355-359
  • Peer Reviewed
• [Journal Article] Experimental investigation of encephalo-myo-synangiosis using gyrenc ephalic brain of the miniature pig: histopathological evaluationof dynamic reconstruction of vessels for functional anastomosis
  • Author(s): Nakamura M, Imai H, Konno K, Kubota C, Seki K, Puentes S, Faried A, Yokoo H, Hata H, Yoshimoto Y, Saito N
  • Journal Title: J Neurosurg (Pediatrics) (In press)
  • Peer Reviewed
• [Presentation] 内頚動脈高度狭窄に対する内膜剥離術の効果:無作為化比較試験に基づくマルコフモデルによる解析 (2009)
  • Author(s): 好本裕平、長岐智仁
  • Organizer: 第68回日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-15