Analysis of Benefit of carotid endarterectomy by mathematical model
| Project/Area Number |
20591682
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Gunma University |
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Principal Investigator |
YOSHIMOTO Yuhei Gunma University, 大学院・医学系研究科, 教授 (50242061)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAKI Tomohoto 群馬大学, 医学部, 助教 (70400760)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 頚動脈内膜剥離術 / マルコフモデル |
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| Research Abstract |
We constructed a Markov model to evaluate effectiveness of carotid endaterectomy (CEA). In modeling four health states, probabilities of transition to another state were estimated using data from major randomized control trials. CEA for severe carotid stenosis would consistently and significantly benefit patients with recent symptoms. However, surgery for asymptomatic stenosis appears justified only in carefully selected conditions : low treatment risks for relatively young individuals without any comorbidities.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Experimental investigation of encephalo-myo-synangiosis using gyrencephalic brain of the miniature pig : histopathological evaluation of dynamic reconstruction of vessels for functional anastomosis.2009
Author(s)
Nakamura M, Imai H, Konno K, Kubota C, Seki K, Puentes S, Faried A, Yokoo H, Hata H, Yoshimoto Y, Saito N
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Journal Title
J Neurosurg : Pediatrics 3
Pages: 488-495
Related Report
Peer Reviewed
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[Journal Article] Experimental model of lacunar infarction in the gyrencephalic brain of the miniature pig : neurological assessment and histological, immunohistochemical, and physiological evaluation of dynamic corticospinal tract deformation.2008
Author(s)
Tanaka Y, Imai H, Konno K, Miyagishima T, Kubota C, Sandra P, Aoki T, Hata H, Yoshimoto Y, Saito N
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Experimental investigation of encephalo-myo-synangiosis using gyrenc ephalic brain of the miniature pig: histopathological evaluationof dynamic reconstruction of vessels for functional anastomosis
Author(s)
Nakamura M, Imai H, Konno K, Kubota C, Seki K, Puentes S, Faried A, Yokoo H, Hata H, Yoshimoto Y, Saito N
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Journal Title
J Neurosurg (Pediatrics) (In press)
Related Report
Peer Reviewed
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