• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanisms of stroke progression by periodontal bacteria

Research Project

Project/Area Number 20591683
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

HOKAMURA Kazuya  Hamamatsu University School of Medicine, 医学部・薬理学, 特任助教 (90436965)

Co-Investigator(Kenkyū-buntansha) UMEMURA Kazuo  浜松医科大学, 医学部・薬理学, 教授 (40232912)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords脳梗塞 / 脳出血 / 口腔内細菌 / う蝕 / 歯周病 / 全身疾患 / 歯周病菌 / う蝕菌
Research Abstract

It was demonstrated with oral bacteria to mice cerebral hemorrhage model, and 24 hours later, brain tissue harvested 2 mm thickness and analyzed brain hemorrhage area. Administered with general oral bacteria was no effect to the cerebral hemorrhage. However, with collagen binding protein was enhanced cerebral hemorrhage during a stroke.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (7 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)

  • [Journal Article] 動脈瘤を引き起こす歯周病菌の解析2011

    • Author(s)
      外村和也、梅村和夫
    • Journal Title

      Oral Dis 17

      Pages: 370-378

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ここまでわかった口腔細菌による全身疾患:最新の研究と臨床治験2011

    • Author(s)
      外村和也、梅村和夫
    • Journal Title

      Jpn J clin Pharmacol ther 42

      Pages: 69-70

    • Related Report
      2010 Final Research Report
  • [Journal Article] 動脈瘤を引き起こす歯周病菌の解析2011

    • Author(s)
      外村和也
    • Journal Title

      Oral Dis

      Volume: 17 Pages: 370-378

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ここまでわかった口腔細菌による全身疾患:最新の研究と臨床治験2011

    • Author(s)
      外村和也
    • Journal Title

      Jpn J clin Pharmacol ther

      Volume: 42 Pages: 69-70

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 口腔細菌の感染による血管過形成の分子解析2010

    • Author(s)
      外村和也、梅村和夫
    • Journal Title

      Journal of Periodontal Research 45

      Pages: 337-344

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口腔細菌が循環器疾患に関わる-分子レベルから臨床まで-2010

    • Author(s)
      外村和也、梅村和夫
    • Journal Title

      J Pharmacol Sci 113

      Pages: 110-114

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口腔細菌の感染による血管過形成の分子解析2010

    • Author(s)
      外村和也
    • Journal Title

      Journal of Periodontal Research

      Volume: 45 Pages: 337-344

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔細菌が循環器疾患に関わる-分子レベルから臨床まで-2010

    • Author(s)
      外村和也
    • Journal Title

      J Pharmacol Sci

      Volume: 113 Pages: 110-114

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔細菌の感染による血管過形成の分子解析2010

    • Author(s)
      外村和也
    • Journal Title

      Journal of Periodontal Research 45

      Pages: 337-344

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of S100 calcium-binding protein A9 is required for induction of smooth muscle cell proliferation by a periodontal pathogen.2009

    • Author(s)
      Hokamura K, Inaba H, Wadak, Umemura K, et al.
    • Journal Title

      FEBS letters 583

      Pages: 128-134

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ここまでわかった口腔細菌による全身疾患:最新の研究と臨床治験2010

    • Author(s)
      外村和也、梅村和夫
    • Organizer
      日本臨床薬理学会
    • Place of Presentation
      京都国際会議所(京都)
    • Year and Date
      2010-12-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳梗塞治療2つのアプローチ2010

    • Author(s)
      外村和也、梅村和夫
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2010-03-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳梗塞治療、2つのアプローチ2010

    • Author(s)
      外村和也
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2010-03-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔細菌、S.mutansは脳出血を増悪させる2009

    • Author(s)
      外村和也、梅村和夫
    • Organizer
      日本脳循環代謝学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2009-11-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 口腔細菌、S. mutans は脳出血を増悪させる2009

    • Author(s)
      外村和也
    • Organizer
      日本脳循環代謝学会
    • Place of Presentation
      千里ライフサイエンスセンター (大阪)
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Periodontosis Bacterium, Porphyromonas Gingivalis is Asociated with Development of Arteriosclerosis by Up-regul ating the Sl00 Calcium Binding-protein A92009

    • Author(s)
      外村和也, 梅村和夫
    • Organizer
      第73回日本循環器学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 循環器系全身疾患(発症)における口腔細菌の関与-分子メカニズムから臨床知見まで-2009

    • Author(s)
      外村和也, 梅村和夫
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-03-16
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 高病原性口腔細菌による腸炎誘発原因分子の産生とその高感度検出法2010

    • Inventor(s)
      外村和也、梅村和夫
    • Industrial Property Rights Holder
      外村和也、梅村和夫
    • Filing Date
      2010-03-03
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 高病原性口腔細菌の高感度検出法2010

    • Inventor(s)
      梅村和夫, 外村和也, 大嶋隆, 和田孝一郎, 仲野和彦, 野村良太
    • Industrial Property Rights Holder
      国立大学法人浜松医科大学
    • Filing Date
      2010-03-15
    • Related Report
      2009 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 高病原性口腔細菌の好感度検出法2009

    • Inventor(s)
      外村和也、梅村和夫
    • Industrial Property Rights Holder
      外村和也、梅村和夫
    • Industrial Property Number
      2009-088239
    • Filing Date
      2009-03-31
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 高病原性口腔細菌の高感度検出法2009

    • Inventor(s)
      外村和也, 梅村和夫, 仲野和彦, 大嶋隆, 野村良太, 和田孝一郎
    • Industrial Property Rights Holder
      国立大学法人浜松医科大学国立大学法人大阪大学
    • Industrial Property Number
      2009-088239
    • Filing Date
      2009-03-31
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi