Clinical application and the validation of 3T-MRI based multi-tensor fiber tractography

• Project/Area Number: 20591685
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka University
• Principal Investigator: HASHIMOTO Naoya Osaka University, 大学院・医学系研究科, 准教授 (90315945)
• Co-Investigator(Kenkyū-buntansha): YAMADA Kei 京都府立医科大学, 医学系研究科, 講師 (80315960) ; YOSHIMINE Toshiki 大阪大学, 大学院・医学系研究科, 教授 (00201046)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 3T-MRI / 拡散テンソル / マルチテンソル / トラクトグラフィー / 電気生理学的検証

Research Abstract

A novel approach of fiber tractography named "multi-tensor tractography (MT)" was applied to 3T-MRI based DTI and successfully used in neurosurgery to improve the accuracy of neuro-navigational system. Then, MT mounted on the system has been validated by intra-operative electrophysiological monitoring and mapping.

Research Products

• [Journal Article] A Survey of Disclosure of Diagnosis to Patients with Glioma in Japan (2011)
  • Author(s): Yamamoto Fukuko
  • Journal Title: International Journal of Clinical Oncology Volume: (In press)
  • Peer Reviewed
• [Journal Article] Diffusion tensor based tumor infiltration index cannot discriminate vasogenic edema from tumor-infiltrated edema. (2010)
  • Author(s): Kinoshita M, Goto T, Okita Y, Kagawa N, Kishima H, Hashimoto N, Yoshimine T
  • Journal Title: Neuro-oncol 96 Pages: 409-415
  • Peer Reviewed
• [Journal Article] 11C-methionine uptake correlates with tumor cell density rather than with microvessel density in glioma : a stereotactic image-histology comparison. (2010)
  • Author(s): Okita Y, Kinoshita M, Goto T, Kagawa N, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T
  • Journal Title: Neuroimage 49 Pages: 2977-2982
  • Peer Reviewed
• [Journal Article] A surgically treated case of Lhermitte-Duclos disease with a precise natural history and high uptake of FDG on PET. (2010)
  • Author(s): Goto Y, Hashimoto N, Okita Y, Goto T, Rabo C, Hirayama H, Horikawa Y, Kinoshita M, Kagawa N, Yoshimine T
  • Journal Title: J Neuro-oncol 97 Pages: 445-450
  • Peer Reviewed
• [Journal Article] MR molecular imaging of HER-2 in a murine tumor xenograft by SPIO labeling of anti-HER-2 affibody. (2010)
  • Author(s): Kinoshita M, Yoshioka Y, Okita Y, Hashimoto N, Yoshimine T
  • Journal Title: Contrast Media Mol Imaging 5 Pages: 18-22
  • Peer Reviewed
• [Journal Article] MR Imaging of Ventral Thalamic Nuclei. (2010)
  • Author(s): Yamada K, Akazawa K, Yuen S, Goto M, Matsushima S, Takahata A, Nakagawa M, Mineura K, Nishimura T
  • Journal Title: AJNR Am J Neuroradiol 31 Pages: 732-735
  • Peer Reviewed
• [Journal Article] Cerebral white matter lesions may be partially reversible in patients with carotid artery stenosis. (2010)
  • Author(s): Yamada K, Sakai K, Owada K, Mineura K, Nishimura T
  • Journal Title: AJNR Am J Neuroradiol 31 Pages: 1350-1352
  • Peer Reviewed
• [Journal Article] Optimum b value for resolving crossing fibers : a study with standard clinical b value using 1.5-T MR. (2010)
  • Author(s): Akazawa K, Yamada K, Matsushima S, Goto M, Yuen S, Nishimura T
  • Journal Title: Neuroradiology 52 Pages: 723-728
  • Peer Reviewed
• [Journal Article] In vivo assessment of peripheral nerve regeneration by diffusion tensor imaging. (2010)
  • Author(s): Morisaki S, Kawai Y, Umeda M, Nishi M, Oda R, Fujiwara H, Yamada K, Higuchi T, Tanaka C, Kawata M, Kubo T
  • Journal Title: J Magn Reson Imaging 31 Pages: 535-542
  • Peer Reviewed
• [Journal Article] Diffusion tensor based tumor infiltration index cannot discriminate vasogenic edema from tumor-infiltrated edema (2010)
  • Author(s): Kinoshita Manabu
  • Journal Title: J Neuro-oncol Volume: 96 Pages: 409-415
  • Peer Reviewed
• [Journal Article] 11C-methionine uptake correlates with tumor cell density rather than with microvessel density in glioma : a stereotactic image-histology comparison (2010)
  • Author(s): Okita Yoshiko
  • Journal Title: Neuroimage. Volume: 49 Pages: 2977-2982
  • Peer Reviewed
• [Journal Article] MR molecular imaging of HER-2 in a murine tumor xenograft by SPIO labeling of anti-HER-2 affibody. (2010)
  • Author(s): Kinoshita Manabu
  • Journal Title: Contrast Media Mol Imaging Volume: 5 Pages: 18-22
  • Peer Reviewed
• [Journal Article] Effects of concomitant temozolomide and radiation therapies on WT1-specific T cells in malignant glioma. (2010)
  • Author(s): Chiba Yasuyoshi
  • Journal Title: JPN J Clin Oncol Volume: 40 Pages: 395-408
  • Peer Reviewed
• [Journal Article] Immunohistological profiling by B-cell differentiation status of primary central nervous system lymphoma treated by high-dose methotrexate chemotherapy (2010)
  • Author(s): Kinoshita Manabu
  • Journal Title: J Neuro-oncol Volume: 99 Pages: 95-101
  • Peer Reviewed
• [Journal Article] Prognostic value of WT1 protein expression level and MIB-1 staining index as predistor of response to WT1 immunotherapy in glioblastoma patients (2010)
  • Author(s): Chiba Yasuyoshi
  • Journal Title: Brain Tumor Pathol Volume: 27 Pages: 29-34
  • Peer Reviewed
• [Journal Article] A rare case of a simultaneously detected suprasellar and intramedullary spinal cord germinoma (2010)
  • Author(s): Carter S.Rabo
  • Journal Title: Brain Tumor Pathol Volume: 27 Pages: 117-120
  • Peer Reviewed
• [Journal Article] Posttransplant Lymphoproliferative Disease of the Central Nervous System After Kideny Transplantation : Single Center Experience Over 40 Years-Two Case Reports-. (2010)
  • Author(s): Arita Hideyuki
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 50 Pages: 1079-1083
  • Peer Reviewed
• [Journal Article] Diffusion tensor based tumor infiltration index cannot discriminate vasogenic edema from tumor-infiltrated edema (2010)
  • Author(s): Manabu Kinoshita
  • Journal Title: Journal of Neuro-oncology 96 Pages: 409-415
  • Peer Reviewed
• [Journal Article] 11C-methionine uptake correlates with tumor cell density rather than with microvessel density in glioma : a stereotactic image-histology comparison (2010)
  • Author(s): Yoshiko Okita
  • Journal Title: Neuroimage 49 Pages: 2977-2982
  • Peer Reviewed
• [Journal Article] Immunohistological profiling by B-cell differentiation status of primary central nervous system lymphoma treated by high-dose methotrexate chemotherapy (2010)
  • Author(s): Manabu Kinoshita
  • Journal Title: Journal of Neuro-oncology
  • Peer Reviewed
• [Journal Article] MR molecular imaging of HER-2 in a murine tumor xenograft by SPIO labeling of anti-HER-2 affibody (2010)
  • Author(s): Manabu Kinoshita
  • Journal Title: Contrast Media Molecular Imaging (in press)
  • Peer Reviewed
• [Journal Article] Effects of concomitant temozolomide and radiation therapies on WT1-specific T cells in malignant glioma (2010)
  • Author(s): Yasuyoshi Chiba
  • Journal Title: Japanese Journal of Clinical Oncology (in press)
  • Peer Reviewed
• [Journal Article] Prognostic Value of WT1 Protein Expression Level and MIB-1 Staining Index as Predictor of Response to WT1 Immunotherapy in Glioblastoma Patients (2010)
  • Author(s): Yasuyoshi Chiba
  • Journal Title: Brain Tumor Pathology (in press)
  • Peer Reviewed
• [Journal Article] A surgically treated case of Lhermitte-Duclos disease with a precise natural history and high uptake of FDG on PET (2010)
  • Author(s): Yuko Goto
  • Journal Title: Journal of Neuro-oncology (in press)
  • Peer Reviewed
• [Journal Article] Use of fractional anisotropy for determination of the cut-off value in 11C-methionine positron emission tomography for glioma. (2009)
  • Author(s): Kinoshita M, Hashimoto N, Goto T, Kagawa N, Kishima H, Izumoto S, Tanaka H, Fujita N, Yoshimine T
  • Journal Title: Neuroimage 45 Pages: 312-318
  • Peer Reviewed
• [Journal Article] Serial volumetric assessmsent of the natural history and growth pattern of incidentally discovered meniniomas. (2009)
  • Author(s): Hashiba T, Hashimoto N, Izumoto S, Suzuki T, Kagawa N, Maruno M, Kato A, Yoshimine T
  • Journal Title: Jornal of Neurosurgery 110(4) Pages: 675-684
  • Peer Reviewed
• [Journal Article] Assessment of arcuate fasciculus with diffusion-tensor tractography may predict the prognosis of aphasia in patients with left middle cerebral artery infarcts. (2009)
  • Author(s): Hosomi A, Nagakane Y, Yamada K, Kuriyama N, Mizuno T, Nishimura T, Nakagawa M
  • Journal Title: Neuroradiology 51 Pages: 549-555
  • Peer Reviewed
• [Journal Article] Diffusion tensor tractography should be used with caution. (2009)
  • Author(s): Yamada K
  • Journal Title: Proc Natl Acad Sci USA 106
  • Peer Reviewed
• [Journal Article] Diffusion tensor imaging may help the determination of time at onset in cerebral ischaemia. (2009)
  • Author(s): Sakai K, Yamada K, Nagakane Y, Mori S, Nakagawa M, Nishimura T
  • Journal Title: J Neurol Neurosurg Psychiatry 80 Pages: 986-990
  • Peer Reviewed
• [Journal Article] Use of fractional anisotropy for determination of the cut-off value in 11C-methionine positron emission tomography for glioma (2009)
  • Author(s): Manabu Kinoshita
  • Journal Title: Neuroimage 45 Pages: 312-318
  • Peer Reviewed
• [Journal Article] Serial volumetric assessmsent of the natural history and growth pattern of incidentally discovered meniniomas (2009)
  • Author(s): Tetsuo Hashiba
  • Journal Title: Journal of Neurosurgery 110 Pages: 675-684
  • Peer Reviewed
• [Journal Article] 特集1 脳腫瘍の最新の基礎研究 グリオーマのLOH, FISH解析とその応用 (2009)
  • Author(s): 橋本直哉
  • Journal Title: 脳21 12 Pages: 32-37
• [Journal Article] 特集 脳腫瘍研究の最前線-遺伝子解析から治療までWT1遺伝子産物を標的とする脳腫瘍の免疫療法 (2009)
  • Author(s): 橋本直哉
  • Journal Title: BRAIN and NERVE 61 Pages: 805-814
• [Journal Article] 脳腫瘍の最新の基礎研究 グリオーマのLOH, FISH解析とその応用 (2009)
  • Author(s): 橋本直哉
  • Journal Title: 脳21 12 Pages: 32-37
• [Journal Article] Incidental acute infarcts identified on diffusion-weighted images : A university hospital-based study. (2008)
  • Author(s): Yamada K, Nagakane Y, Sasajima H, Nakagawa M, Mineura K, Masunami T, Akazawa K, Nishimura T
  • Journal Title: AJNR Am J Neuroradiol 29 Pages: 937-940
  • Peer Reviewed
• [Journal Article] Cerebral white matter damage in frontotemporal dementia assessed by diffusion tensor tractography. (2008)
  • Author(s): Matsuo K, Mizuno T, Yamada K, Akazawa K, Kasai T, Kondo M, Mori S, Nishimura T, Nakagawa M
  • Journal Title: Neuroradiology 50 Pages: 605-611
  • Peer Reviewed
• [Journal Article] Alteration of fractional anisotropy and apparent diffusion coefficient in obsessive-compulsive disorder : A diffusion tensor imaging study. (2008)
  • Author(s): Nakamae T, Narumoto J, Shibata K, Matsumoto R, Kitabayashi Y, Yoshida t, Yamada K, Nishimura T, Fukui K
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 32 Pages: 1221-1226
  • Peer Reviewed
• [Journal Article] Variability in absolute apparent diffusion coefficient values across different platforms may be substantial : A multivendor, multi-institutional comparison study. (2008)
  • Author(s): Sasaki M, Yamada K, Watanabe Y, Matsui M, Ida M, Fujiwara S, Shibata E
  • Journal Title: Radiology 249 Pages: 624-630
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of adhesion molecules and matrixmetalloproteinases in malignant CNS lymphomas : a studycomparing primary CNS malignant and CNS intravascularlymphomas (2008)
  • Author(s): Manabu Kinoshita
  • Journal Title: Brain Tumor Pathology 25 Pages: 73-78
  • Peer Reviewed
• [Journal Article] Serial volumetric assessmsent of the natural history and growthpattern of incidentally discovered meniniomas (2008)
  • Author(s): Hashiba Tetsuo
  • Journal Title: Jornal of Neurosurgery(Epub ahead ofprint)
  • Peer Reviewed
• [Presentation] 高齢者悪性神経膠腫に対するテモゾロミド併用放射線療法とその副作用について (2011)
  • Author(s): 山本福子
  • Organizer: 第24回日本老年脳神経外科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-03-18
• [Presentation] Novel "Subcortical" Stimulation and Detection of Sensori-visual Evoked Potentials for the Validation of Fiber-tractography. (2011)
  • Author(s): Hashimoto N, Goto T, Yamada K
  • Organizer: The 2nd International Symposium on the Project Computational Anatomy
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2011-03-06
• [Presentation] Anatomical Validation and Clinical Feasibility of Fiber-Tractography Based on Diffusion Tensor Imaging. (2011)
  • Author(s): Hashimoto N, Goto T, Yamada K
  • Organizer: The 2nd International Symposium on the Project Computational Anatomy
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2011-03-06
• [Presentation] Anatomical Validation and Clinical Feasibility of Fiber-Tractography Based on Diffusion Tensor Imaging (2011)
  • Author(s): Hashimoto Naoya
  • Organizer: The 2nd International Symposium on the Project 'Computational Anatomy'
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2011-03-06
• [Presentation] Novel "Subcortical" Stimulation and Detection of Sensori-visual Evoked Potentials for the Validation of Fiber-tractography (2011)
  • Author(s): Hashimoto Naoya
  • Organizer: The 2nd International Symposium on the Project 'Computational Anatomy'
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2011-03-06
• [Presentation] 脳腫瘍に対するペプチドワクチン療法の現状と展望 (2011)
  • Author(s): 橋本直哉
  • Organizer: 第2回栃木ニューロオンコロジー研究会
  • Place of Presentation: 宇都宮(招待講演)
  • Year and Date: 2011-01-21
• [Presentation] 脳深部腫瘍に対する神経内視鏡アプローチ (2010)
  • Author(s): 藤本康倫
  • Organizer: 第15回関西脳神経外科手術研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-18
• [Presentation] 悪性神経膠腫に対するがんワクチン療法 大阪大学によるWT1療法の治療成績とBGFRvIIIワクチンの海外臨床試験レビュー (2010)
  • Author(s): 橋本直哉
  • Organizer: 平成22年度瀬谷班・平家小班合同班会議
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-12-13
• [Presentation] Navigation-guided neuroendoscopic biopsy for intraparechymal brain tumors (2010)
  • Author(s): Fujimoto Yasunori
  • Organizer: IFNE (International Federation of Neuroendoscopy) Interim Meeting : The Neuroendoscopy Masters
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2010-12-12
• [Presentation] 脳室炎を合併した水頭症に対して内視鏡下洗浄術が有効であった1例 (2010)
  • Author(s): 平山龍一
  • Organizer: 第17回日本神経内視鏡学会
  • Place of Presentation: 千葉
  • Year and Date: 2010-12-11
• [Presentation] WT1 peptide immunotherapy for brain tumor evaluted by ^<11>C-Methionine PET (2010)
  • Author(s): Hashimoto Naoya
  • Organizer: 2^<nd> Clinical Immuno-Imaging Conference
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-10
• [Presentation] 経鼻的内視鏡手術のトレーニング:トレーニングボックスの有用性 (2010)
  • Author(s): 藤本康倫
  • Organizer: 第17回日本神経内視鏡学会
  • Place of Presentation: 千葉
  • Year and Date: 2010-12-10
• [Presentation] 頭蓋内胚細胞腫に対する内視鏡的腫瘍生検術の役割 (2010)
  • Author(s): 香川尚己
  • Organizer: 第17回日本神経内視鏡学会
  • Place of Presentation: 千葉
  • Year and Date: 2010-12-10
• [Presentation] 膠芽種に対するWT1ペプチドワクチン療法における長期生存例と予後予測因子 (2010)
  • Author(s): 橋本直哉
  • Organizer: 第23回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-09
• [Presentation] 勤務施設や専門性による悪性神経膠腫患者への告知の違いについて (2010)
  • Author(s): 山本福子
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-30
• [Presentation] WT1 免疫療法効果判定における11C-methionine PETの新たな解析法 (2010)
  • Author(s): 千葉泰良
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-29
• [Presentation] 新規脳腫瘍幹細胞マーカー(BTSC4)が悪性神経膠腫の浸潤能へ及ぼす影響 (2010)
  • Author(s): 木嶋教行
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-29
• [Presentation] 当院における頭蓋内胚細胞腫の診断と治療成績 (2010)
  • Author(s): 香川尚己
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-29
• [Presentation] テモゾロミド投与に伴うB型肝炎ウイルスの再活性化:症例報告とその対策 (2010)
  • Author(s): 藤本康倫
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-29
• [Presentation] 再発成人CNS PNETに対するWT1免疫療法の試み (2010)
  • Author(s): 泉本修一
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-29
• [Presentation] 膠芽種に対するWT1ペプチドワクチン療法における長期生存例と予後予測因子 (2010)
  • Author(s): 橋本直哉
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-28
• [Presentation] T2高輝度領域でのglucose/methionine代謝の非同期性を用いたグリオーマ浸潤の画像化 (2010)
  • Author(s): 木下学
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-28
• [Presentation] Glucose and methionine uptake decouples in T2-hyperintese area with tumor infiltration but not in pure vasogenic edema. (2010)
  • Author(s): Kinoshita M, Goto T, Kagawa N, Fujimoto Y, Kishima H, Hatazawa J, Hashimoto N, Yoshimine T
  • Organizer: Neuroscience 2010 -40^<th> Annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-16
• [Presentation] Glucose and methionine uptake decouples in T2-hyperintense area with tumorinfiltration but not in pure vasogenic edema : A voxel-by-voxel positron emission tomographic study (2010)
  • Author(s): KINOSHITA Manabu
  • Organizer: Neuroscience 2010
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-16
• [Presentation] WT1ペプチドを用いた悪性脳腫瘍の治療 (2010)
  • Author(s): 橋本直哉
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-30
• [Presentation] 悪性グリオーマに対するWT1免疫療法後の浸潤リンパ球と免疫逃避 (2010)
  • Author(s): 千葉泰良
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-29
• [Presentation] 膠芽腫に対するWT1ペプチドワクチン療法の新たな知見:長期生存例、予後予測因子と新規臨床試験 (2010)
  • Author(s): 橋本直哉
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-29
• [Presentation] 神経内視鏡による脳実質内腫瘍の手術 (2010)
  • Author(s): 藤本康倫
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-29
• [Presentation] 皮質下脳波計測による神経白質線維の活動計測. (2010)
  • Author(s): 後藤哲、平田雅之、橋本直哉、貴島晴彦、柳澤琢史、齋藤洋一、佐野史郎、吉峰俊樹
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-28
• [Presentation] 無症候性病変の手術適応と手術時期. (2010)
  • Author(s): 吉峰俊樹、橋本直哉、羽柴哲夫、後藤哲、沖田典子、Rabo Carter、藤本康倫、香川尚己、木下学、山本福子、木嶋教行、有田英之
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-28
• [Presentation] 無症候性病変の手術適応と手術時期 (2010)
  • Author(s): 吉峰俊樹
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-28
• [Presentation] 皮質下脳波計測による神経白質線維の活動計測 (2010)
  • Author(s): 後藤哲
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-28
• [Presentation] 日本における悪性神経膠腫患者に対する病名告知の動向 (2010)
  • Author(s): 山本福子
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-28
• [Presentation] 多画像同時解析による新規画像診断法の開発:voxel-wise analysisが可能にする真のマルチモダール画像解析 (2010)
  • Author(s): 木下学、後藤哲、有田英之、沖田典子、香川尚己、藤本康倫、貴島晴彦、畑澤順、橋本直哉、吉峰俊樹
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-27
• [Presentation] 多画像同時解析による新規画像診断法の開発voxel-wise analysisが可能にする真のマルチモダール画像解析 (2010)
  • Author(s): 木下学
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-27
• [Presentation] 悪性神経膠腫における新規脳腫瘍幹細胞マーカーbrain tumor stem cell marker4(BTSC4)の機能的役割 (2010)
  • Author(s): 木嶋教行
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-27
• [Presentation] 小児髄芽腫治療における長期臨床成績と今後の課題 (2010)
  • Author(s): 香川尚己
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-27
• [Presentation] Affibodyを用いたMRIによるHER-2受容体の分子イメージング (2010)
  • Author(s): 木下学、吉岡芳親、沖田典子、橋本直哉、吉峰俊樹
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] 悪性神経膠腫における新規脳腫瘍幹細胞マーカーbrain tumor stem cell marker 4(BTSC4)の機能的役割 (2010)
  • Author(s): 木嶋教行
  • Organizer: 第11回日本分子脳神経外科学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-08-27
• [Presentation] 脳腫瘍、転移性脳腫瘍での薬剤移行について (2010)
  • Author(s): 橋本直哉
  • Organizer: 中外製薬大阪支店研修会における学術講演
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2010-08-24
• [Presentation] 鎖肛および後彎変形を合併した巨大な脊髄髄膜瘤に対する治療経験 (2010)
  • Author(s): 香川尚己
  • Organizer: 第27回日本二分脊椎研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-07-24
• [Presentation] Analysis of diagnostic surgical strategies for intracranial germinomas (2010)
  • Author(s): Kagawa Naoki
  • Organizer: The 14th International Symposium on Pediatric Neuro-Oncology-ISPNO 2010
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2010-06-22
• [Presentation] Stereotactic Image-Histology Comparison Among 11C-Methionine Uptake and Histopathology in Gliomas. (2010)
  • Author(s): 沖田典子, 木下学, Goto T, 香川尚己, 木嶋教行, 橋本直哉, 吉峰俊樹
  • Organizer: 7th Meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-06-12
• [Presentation] WT1 Immunotherapy for Malignant Gliomas ; DTH and Methionine PET as Strong Prognostic Indicators (2010)
  • Author(s): Hashimoto Naoya
  • Organizer: 7th Meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-06-12
• [Presentation] Surgical Neuro-Oncologists' Attitudes Toward the Disclosure to Glioma Patients in Japan (2010)
  • Author(s): Yamamoto Fukuko
  • Organizer: 7th Meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-06-12
• [Presentation] Use of Temozolomide, Antiepileptic Agents and Steroids does not Affect Negatively the Therapeutic Impact of WT1 Peptide Vaccination for Patients with Malignant Gliomas (2010)
  • Author(s): Chiba Yasuyoshi
  • Organizer: 7th Meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-06-12
• [Presentation] Stereotactic Image-Histology Comparison Among 11C-Methionine Uptake and Histopathology in Gliomas (2010)
  • Author(s): Okita Yoshiko
  • Organizer: 7th Meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-06-12
• [Presentation] 再発髄芽腫に対する集学的治療 (2010)
  • Author(s): 香川尚己
  • Organizer: 第38回日本小児外科学会
  • Place of Presentation: 富山
  • Year and Date: 2010-06-05
• [Presentation] 小児広範囲頭蓋骨欠損に対するカスタムメイド人口骨と修正プレートによる頭蓋形成術 (2010)
  • Author(s): 圓尾知之
  • Organizer: 第38回日本小児外科学会
  • Place of Presentation: 富山
  • Year and Date: 2010-06-05
• [Presentation] 脳瘤の病理学的および免疫組織学的検討 (2010)
  • Author(s): 千葉泰良
  • Organizer: 第38回日本小児外科学会
  • Place of Presentation: 富山
  • Year and Date: 2010-06-05
• [Presentation] WT1免疫療法による悪性グリオーマの組織学的変化 (2010)
  • Author(s): 千葉泰良
  • Organizer: 第28回日本脳腫瘍病理学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-05-22
• [Presentation] 第3脳室、第4脳室内に同時発生した中枢神経系primitive neuroectodormal tumor(cPNET)の剖検例 (2010)
  • Author(s): 木嶋教行
  • Organizer: 第28回日本脳腫瘍病理学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-05-21
• [Presentation] MR molecular imaging of HER-2 in a murine tumor xenograft by SPIO labeling of anti-HER-2 Affibody. (2010)
  • Author(s): 木下学, 吉岡芳親, 沖田典子, 橋本直哉, 吉峰俊樹
  • Organizer: International Society for Magnetic Resonance in Medicine (ISMRM) 18th Scientific Meeting
  • Place of Presentation: Stockholm, Sweeden
  • Year and Date: 2010-05-03
• [Presentation] MR molecular imaging of HER-2 in a murine tumor xenograft by SPIO labeling of anti-HER-2 Affibody (2010)
  • Author(s): Kinoshita Manabu
  • Organizer: International Society for Magnetic Resonance in Medicine (ISMRM) 18th Scientific Meeting.
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-05-03
• [Presentation] メチオニンPETの functional PET analysis による悪性グリオーマに対するWT-1免疫療法の治療効果解析 (2010)
  • Author(s): 木下学
  • Organizer: 第33回日本脳神経CI学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-02-11
• [Presentation] 星状細胞腫と乏突起膠腫における11c-methionine PETと悪性度、血管密度の定位的検討 (2009)
  • Author(s): 沖田典子
  • Organizer: 第21回日本脳循環代謝学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-20
• [Presentation] 星状細胞腫と乏突起膠腫における11c-methionine PETの組織成分の差異に関わる検討 (2009)
  • Author(s): 沖田典子
  • Organizer: 第27回日本脳腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-09
• [Presentation] WT1免疫療法の新たな展開 : テモゾロミドの免疫系への影響と治療効果のモニタリング (2009)
  • Author(s): 橋本直哉
  • Organizer: 第27回日本脳腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-09
• [Presentation] 拡散テンソル画像によるtumor infiltration indexは悪性gliomaの浸潤評価に有用か? (2009)
  • Author(s): 木下学、後藤哲、沖田典子、香川尚己、貴島晴彦、橋本直哉、吉峰俊樹
  • Organizer: 第27回日本脳腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-08
• [Presentation] 拡散テンソル画像による tumor infiltration index は悪性 glioma の浸潤評価に有用か? (2009)
  • Author(s): 木下学
  • Organizer: 第27回日本脳腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-08
• [Presentation] 脳腫瘍摘出術中に施行した覚醒下鈎状束電気刺激中に認めた意図性保続について (2009)
  • Author(s): 野村慶子
  • Organizer: 第33回日本高次脳機能障害学会学術総会
  • Place of Presentation: 北海道 (札幌)
  • Year and Date: 2009-10-29
• [Presentation] Glioma における11C-methionine PETの定位的病理学的検討 (2009)
  • Author(s): 沖田典子
  • Organizer: 第68回日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-16
• [Presentation] WT1免疫療法の効果判定における pseudoprogression と11C-methionine PETの有用性 (2009)
  • Author(s): 千葉泰良
  • Organizer: 第68回日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-15
• [Presentation] 悪性グリオーマにおけるモニタリングと長期成績:現状と今後の展望. (2009)
  • Author(s): 橋本直哉, 木嶋教行, 千葉泰良, 沖田典子, 山本福子, 後藤哲, 平田雅之, 木下学, 香川尚己, 吉峰俊樹
  • Organizer: 第68回日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-14
• [Presentation] 悪性グリオーマにおけるモニタリングと長期成績 : 現状と今後の展望 (2009)
  • Author(s): 橋本直哉
  • Organizer: 第68回日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-14
• [Presentation] 言語領野近傍の手術におけるmultitensor fiber tractographyとmethioninePETとの有効利用:覚醒下手術の迅速化. (2009)
  • Author(s): 橋本直哉, 木嶋教行, 千葉泰良, 沖田典子, 山本福子, 後藤哲, 平田雅之, 木下学, 香川尚己, 吉峰俊樹
  • Organizer: 第14回日本脳腫瘍の外科学会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-25
• [Presentation] 言語領野近傍の手術における multitensor fiber tractography と methionine PETとの有効利用 : 覚醒下手術の迅速化 (2009)
  • Author(s): 橋本直哉
  • Organizer: 第14回日本脳腫瘍の外科学会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-25
• [Presentation] 髄膜腫における11C-methionine PETの定位的病理学的検討 (2009)
  • Author(s): 沖田典子
  • Organizer: 第58回日本脳神経外科学会・近畿支部学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-09-19
• [Presentation] 脳神経外科領域における^<11>C-メチオニンPETの臨床応用とその展望 (2009)
  • Author(s): 橋本直哉
  • Organizer: 阪和インテリジェント医療センター3周年記念講演会-PET検査の新たなる展開-
  • Place of Presentation: 大阪 (堺市)
  • Year and Date: 2009-05-21
• [Presentation] Glioma におけるMET-PETの定位的病理学的検討と血管密度の関係、Stereotactic compalison among Methionine update, microvessel density and pathological implication in glioma (2009)
  • Author(s): 沖田典子
  • Organizer: 第27回日本脳腫瘍学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-08
• [Presentation] Use of fractional anisotropy for determination of the cut-off value in 11C-methionine positron emission tomography for glioma. (2009)
  • Author(s): 木下学, 橋本直哉, Goto T, 柳澤琢史, 香川尚己, 木嶋教行, 畑澤順, 吉峰俊樹
  • Organizer: ISMRM 17th Annual Meeting and Exhibition
  • Place of Presentation: Honululu, USA
  • Year and Date: 2009-04-23
• [Presentation] 左島弁蓋部神経膠腫に対してマルチモダリティー覚醒手術を施行した一症例 (2009)
  • Author(s): 後藤雄子、平田雅之、後藤哲、沖田典子、山本福子、千葉泰良、木下学、香川尚己、橋本直哉、吉峰俊樹
  • Organizer: 近畿脳腫瘍研究会
  • Place of Presentation: 大阪
  • Year and Date: 2009-04-04
• [Presentation] Use of fractional anisotropy for determination of the cut-off value in methionine PET. (2009)
  • Author(s): 木下学、後藤哲、柳澤琢史、沖田典子、香川尚己、貴島晴彦、橋本直哉、吉峰俊樹
  • Organizer: 第32回日本脳神経CI学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-06
• [Presentation] WT1免疫療法の治療効果判定における11C-methioninePETの有用性 (2009)
  • Author(s): 千葉 泰良
  • Organizer: 第32回日本脳神経CI学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-06
• [Presentation] Use of fractional anisotropy for determination of the cut-off valuein methionine PET. (2009)
  • Author(s): 木下 学
  • Organizer: 第32回日本脳神経CI学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-06
• [Presentation] 拡散テンソル画像による細胞密度、増殖能の評価とFDG-PETとの相関性 (2008)
  • Author(s): 木下学、沖田典子、後藤哲、山本福子、千葉泰良、香川尚己、貴島晴彦、橋本直哉、吉峰俊樹
  • Organizer: 第26回日本脳腫瘍学会
  • Place of Presentation: 松山
  • Year and Date: 2008-12-02
• [Presentation] 拡散テンソルが創により細胞密度、増殖能の評価とFDG-PETとの相関性 (2008)
  • Author(s): 木下 学
  • Organizer: 第26回日本脳腫瘍学会
  • Place of Presentation: 松山
  • Year and Date: 2008-12-02
• [Presentation] Multi-tensor fiber trackingのグリオーマ手術への応用 (2008)
  • Author(s): 橋本直哉、後藤哲、沖田典子、山本福子、千葉泰良、木下学、香川尚己、吉峰俊樹
  • Organizer: 第26回日本脳腫瘍学会
  • Place of Presentation: 松山
  • Year and Date: 2008-12-01
• [Presentation] GliomaにおいてMet-PETとFDG-PETから得られる情報の生物学的意義 (2008)
  • Author(s): 沖田典子
  • Organizer: 第26回日本脳腫瘍学会
  • Place of Presentation: 松山
  • Year and Date: 2008-11-30
• [Presentation] MRIによる脳腫瘍の生物学的特性の評価の試み?拡散テンソル画像(DTI)による細胞密度、増殖能の評価- (2008)
  • Author(s): 木下学、橋本直哉、後藤哲、沖田典子、山本福子、千葉泰良、香川尚己、貴島晴彦、吉峰俊樹
  • Organizer: 第67回日本脳神経外科学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2008-10-03
• [Presentation] 11C-methionine PETの手術および治療効果判定への応用 (2008)
  • Author(s): 橋本直哉
  • Organizer: 第67回日本脳神経外科学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2008-10-03
• [Presentation] MRIによる脳腫瘍の生物学的特性の評価の試み-拡散テンソル画像(DTI)による細胞密度、増殖能の評価- (2008)
  • Author(s): 木下 学
  • Organizer: 第67回日本脳神経外科学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2008-10-03
• [Presentation] 脳磁図、皮質電位、ファイバートラッキング、経頭蓋磁気刺激を用いた術前術中視覚機能評価 (2008)
  • Author(s): 平田雅之、橋本直哉、後藤哲、齊藤洋一、貴島晴彦、押野悟、柳澤琢史、細見晃一、依藤史郎、吉峰俊樹
  • Organizer: 第8回日本脳神経外科術中画像研究会
  • Place of Presentation: 大阪
  • Year and Date: 2008-07-26
• [Presentation] Multi-tensor tractographと11C-methionine PETを搭載したナビゲーションシステムによる脳腫瘍の手術 (2008)
  • Author(s): 橋本直哉、平田雅之、沖田典子、後藤哲、山本福子、千葉泰良、木下学、香川尚己、吉峰俊樹
  • Organizer: 第8回日本脳神経外科術中画像研究会
  • Place of Presentation: 大阪
  • Year and Date: 2008-07-26
• [Presentation] Multi-tensor tractographyと1 1 C-methionine PET を搭載したナビゲーションシステムによる脳腫瘍の手術 (2008)
  • Author(s): 橋本直哉
  • Organizer: 第8回日本脳神経外科術中画像研究会
  • Place of Presentation: 大阪
  • Year and Date: 2008-07-26
• [Presentation] 無症候性髄膜腫の自然経過:体積計測による個別未来予測 (2008)
  • Author(s): 橋本直哉、羽柴哲夫、後藤哲、沖田典子、山本福子、千葉泰良、木下学、香川尚己、吉峰俊樹
  • Organizer: 第17回日本脳ドック学会総会
  • Place of Presentation: 郡山
  • Year and Date: 2008-06-28
• [Presentation] 無症候性髄膜腫の自然経過 : 体積計測による個別未来予測 (2008)
  • Author(s): 橋本直哉
  • Organizer: 第17回日本脳ドック学会総会
  • Place of Presentation: 郡山
  • Year and Date: 2008-06-28
• [Presentation] The correlation of tumor cell density and diffusion tensor imaging (2008)
  • Author(s): 木下 学
  • Organizer: 第26回日本脳腫瘍病理学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 画像診断が困難であった腫瘤性病変の病理学的検討 (2008)
  • Author(s): 橋本直哉
  • Organizer: 第26回日本脳腫瘍病理学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Book] Tumors of the Central Nervous System.-Incidentally discovered meningiomas : growth rates and patterns. (2011)
  • Author(s): Hashimoto Naoya
  • Publisher: Springer(In press)
• [Book] 日本臨床 増刊号 新時代の脳腫瘍学 特集 新時代の脳腫瘍学-診断・治療の最前線-脳腫瘍患者および家族への告知の現状と諸問題 (2010)
  • Author(s): 橋本直哉
  • Publisher: 日本臨床
• [Book] 日本臨床 増刊号 新時代の脳腫瘍学 特集 新時代の脳腫瘍学-診断・治療の最前線-WT1遺伝子産物を標的とする免疫療法 (2010)
  • Author(s): 橋本直哉
  • Publisher: 日本臨床
• [Book] 臨床・病理 脳腫瘍取り扱い規約 臨床と病理カラーアトラス 第3版 (2010)
  • Author(s): 青木友和(共著)
  • Publisher: 金原出版
• [Book] 脳磁図、皮質の脳波、ファイバートラキング、経頭蓋磁気刺激を用いた術前・術中視覚機能評価 (2009)
  • Author(s): 平田雅之、後藤哲、谷直樹、甲津彩子、元木優、齋藤洋一、貴島晴彦、橋本直哉、柳澤琢史、細見晃一、依藤史郎、吉峰俊樹
  • Publisher: 臨床脳波 51
• [Book] Incidentally discovered meningiomas : growth rates and patterns. Tumors of the Central Nervous System.
  • Author(s): 橋本直哉, 吉峰俊樹
  • Publisher: Springer (New York)(in press)