New treatment for cerebral infarction using infiltrating cells
| Project/Area Number |
20591687
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Ehime University |
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Principal Investigator |
KUMON Yoshiaki Ehime University, 大学院・医学系研究科, 准教授 (80127894)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Hideaki 愛媛大学, 大学院・医学系研究科, 講師 (30322275)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脳梗塞 / 浸潤細胞 / 神経栄養因子 / 治療 / 脳虚血 / マクロファージ / 神経保護因子 |
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| Research Abstract |
We found that macrophage-like cells accumulate in the ischemic core of a rat brain whose right middle cerebral artery was transiently occluded for 90 minutes. Many of these cells expressed Iba1, a marker of macrophages/microglias, as well as NG2 chondroitin sulfate proteoglycan (NG2), which has been recognized as a marker of oligodendrocyte progenitor cells. Such macrophage-like cells were termed BINCs (brain Iba1+/NG2+cells). BINCs were highly proliferative and their number peaked at 7 days post-reperfusion. Taken the various function of NG2, BINCs may be involved in not only phagocytosis of degenerated cells but also the healing and regeneration of lesion cores. 5-Fluorouracil (5FU) injection at 2 days post reperfusion markedly reduced the number of BINCs at 7 days post reperfusion, causing enlargement of necrotic volumes and frequent death of the rats. When isolated BINCs were transplanted into 5FU-aggravated ischemic lesion, the volume of the lesion was much reduced. Bone marrow-derived BINCs play a benefical role in ischemic brain lesions, at least in part, through secretion of neuroprotective factors.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Iba+/NG2+ macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain.2010
Author(s)
Smirkin A, Matsumoto H, Takahashi H, Inoue A, Tagawa M, Ohue S, Watanabe H, Yano H, Kumon Y, Ohnishi T, Tanaka J
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Journal Title
Journal of Cerebral Blood Flow and Metabolism 30
Pages: 603-615
Related Report
Peer Reviewed
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[Journal Article] Iba1+/NG2+ macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain2010
Author(s)
Smirkin A, Matsumoto H, Takahashi H, Inoue A, Tagawa M, Ohue S, Watanabe H, Yano H, Kumon Y, Ohnishi T, Tanaka J
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Journal Title
Journal of Cereb Blood Flow & Metabolism 30
Pages: 603-615
Related Report
Peer Reviewed
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