| Project/Area Number |
20591691
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
NISHIO Minoru Nagoya City University, 大学院・医学研究科, 助教 (40315891)
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| Co-Investigator(Kenkyū-buntansha) |
MASE Mitsuhito 名古屋市立大学, 大学院・医学研究科, 准教授 (60238920)
YAMADA Kazuo 名古屋市立大学, 大学院・医学研究科, 教授 (90150341)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKURAI Keita 名古屋市立大学, 大学院・医学研究科, 助教 (70453066)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脳脊髄液減少症 / 低髄液圧症候群 / L-PDGS / 髄液漏出 / 低髄液圧症 |
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| Research Abstract |
We measured the lipocain-type prostaglandin D synthetase (L-PDGS) in the cerebrospinal fluid (CSF) and serum samples from 6 patients with CSF leakage and 6 patients without CSF leakage. The L-PDGS levels in the blood serum were compared for a group of patients with and without CSF leakage, for a group of patients with low CSF pressure and normal CSF pressure, and for a group of patients with and without CSF leakage after a lumbar puncture. In the comparison of any groups, significant concentrations of L-PGDS in the blood serum were not detected. Therefore, we conclude that even if a minute amount of CSF leakage occurs, it is difficult to evaluate because it does not affect the L-PDGS concentration levels in the patients' blood.
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