| Project/Area Number |
20591692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
KATANO Hiroyuki Nagoya City University, 大学院・医学研究科, 准教授 (30295612)
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| Co-Investigator(Renkei-kenkyūsha) |
MASE Mitsuhito 名古屋市立大学, 大学院・医学研究科, 准教授 (60238920)
TANIKAWA Motoki 名古屋市立大学, 大学院・医学研究科, 講師 (20343402)
YAMADA Kazuo 名古屋市立大学, 大学院・医学研究科, 教授 (90150341)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 脳血管障害学 / 頚動脈狭窄症 / 頸動脈内膜剥離術 / 頸動脈ステント留置術 / 頸動脈プラーク / 石灰化 / アガツトンカルシウムスコア / マイクロアレイ / 遺伝子発現 |
|---|
| Research Abstract |
We reconstructed MDCT images of the patients of carotid stenoses and calculated Agatston scores (AS). Gene tip expression array analysis was performed after extraction of mRNAs from carotid plaques. Over double difference was noted for the intensity of the expression for inflammation-related genes after comparison of specimens classified based on AS100. Upregulation of NFAT, ADAMTS, Angptl4 and downregulation of Angptl7 were observed in severely calcified plaques.
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