Cerebral hyperperfusion and cognitive impairment after carotid endarterectomy are associated with free radicals produced during surgery
| Project/Area Number |
20591694
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
OGASAWARA Kuniaki Iwate Medical University, 医学部, 教授 (00305989)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳血管障害学 / 頚動脈内膜剥離術 / 過灌流 / 高次脳機能障害 / フリーラジカル / 頸部頸動脈狭窄症 / 内膜剥離術 |
|---|
| Research Abstract |
The aim of the present study was to clarify relationship between development of postoperative cerebral hyperperfusion or cognitive impairment and value of free radicals produced during surgery using electrical spin trapping for blood obtained from catheter set at the jugular bulb in patients undergoing carotid endarterectomy. As a result, value of free radical production during surgery correlated with intensity of cerebral ischemia during carotid occlusion, and excessive free radical production caused postoperative cerebral hyperperfusion and cognitive impairment. Value of free radical production during surgery was significantly lower in patients with free radical scavenger, edaravone, than in those without.
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Report
(4 results)
Research Products
(68 results)
