Exploring a novel neuroprotectant for the treatment of acute traumatic brain injury using experimental model rats
| Project/Area Number |
20591698
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kurume University |
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Principal Investigator |
HASUO Hiroshi Kurume University, 医学部, 准教授 (90172882)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEYA Mitsue 久留米大学, 医学部, 助教 (30289433)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 頭部外傷学 / 神経保護薬 / 脳・神経 / 薬理学 / 生理学 / 神経科学 / 頭部外傷モデル動物 / 液体打撃法 / 脳損傷 / 長期増強 / 海馬核 / エモジン / 大黄(だいおう) |
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| Research Abstract |
Deficient learning and memory are frequently reported as a consequence of traumatic brain injury (TBI). Since long-term potentiation (LTP) is a leading cellular model underlying learning, we investigated the effects of emodin, an active compound of rhubarb extract, on the impairment of LTP observed in the experimental TBI-model rats. As a result, the LTP of emodin-treated group was improved dramatically. Our results in the present study suggest that emodin may be effective therapeutic agents for TBI.
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Report
(4 results)
Research Products
(32 results)
