| Project/Area Number |
20591698
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
HASUO Hiroshi Kurume University, 医学部, 准教授 (90172882)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKEYA Mitsue 久留米大学, 医学部, 助教 (30289433)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 頭部外傷学 / 神経保護薬 / 脳・神経 / 薬理学 / 生理学 / 神経科学 / 頭部外傷モデル動物 / 液体打撃法 / 脳損傷 / 長期増強 / 海馬核 / エモジン / 大黄(だいおう) |
|---|
| Research Abstract |
Deficient learning and memory are frequently reported as a consequence of traumatic brain injury (TBI). Since long-term potentiation (LTP) is a leading cellular model underlying learning, we investigated the effects of emodin, an active compound of rhubarb extract, on the impairment of LTP observed in the experimental TBI-model rats. As a result, the LTP of emodin-treated group was improved dramatically. Our results in the present study suggest that emodin may be effective therapeutic agents for TBI.
|
