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Application of liposome decorated with sugar chains to prevent vascular stenosis after angioplasty

Research Project

Project/Area Number 20591700
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

TSURUSHIMA Hideo  National Institute of Advanced Industrial Science and Technology, 大学院・人間総合科学研究科, 准教授 (50315470)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords脳血管内外科学 / ナノ粒子 / DDS / active targeting / リポソーム / 虚血性疾患 / 血管形成術 / 再狭窄予防 / 糖鎖 / シポソーム / 糖鎖-レクチン蛋白質親和性 / drug delivery system / active targeting DDS / ドキソルビシン / 血管狭窄 / 血管形成術後再狭窄 / 血管狭窄予防
Research Abstract

Restenosis remains a serious complication that can occur after angioplasty. This study investigated the efficiency of an active targeting chemotherapy using liposomes,including doxorubicin, which surface was decorated with sialyl Lewis X (SLX), (Dox-Lipo-SLX), to prevent stenosis after angioplasty. Its delivery was controlled via the affinity between SLX and E-selectin proteins, which are expressed on injured arteries. In vitro experiments confirmed that doxorubicin accumulated owing to Dox-Lipo-SLX by adhering to E-selectin-positive cells. Rats with balloon-injured arteries were intravenously injected with Dox-Lipo-SLX. A significant doxorubicin accumulation was observed on the injured vessel walls in rats treated with Dox-Lipo-SLX. The efficiency of stenosis prevention was evaluated. The residual lumen area of the group treated with Dox-Lipo-SLX was significantly larger than all of the other groups. These results demonstrate that an active targeting drug delivery system with Dox-Lipo-SLX effectively prevents stenosis after angioplasty.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (63 results)

All 2011 2010 2009 2008 Other

All Journal Article (22 results) (of which Peer Reviewed: 21 results) Presentation (23 results) Book (3 results) Remarks (10 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] Newly synthesized radical-containing nanoparticles (RNP) enhance neuroprotection after cerebral ischemia-reperfusion injury.2011

    • Author(s)
      Marushima A, Suzuki K, Nagasaki Y, Yoshitomi T, Toh K, Tsurushima H, Hirayama A, Matsumura A
    • Journal Title

      Neurosurgery (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drug Delivery Systemと単色X線を用いた新規放射線療法2011

    • Author(s)
      鶴嶋英夫、黒田隆之助
    • Journal Title

      物理学会誌 80(2)

      Pages: 120-123

    • NAID

      10027785144

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Time-course analysis of brain perfusion single-photon emission computed tomography using a three-dimentional stereotactic region-of-interest template in patients with Moyamoya disease.2011

    • Author(s)
      Marushima A, Tsurushima H, Suzuki K, Nakai Y, Nemoto H, Matsumura A
    • Journal Title

      World Neurosurg. (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoblast differentiation and disinfection induced by nitrogen plasma-treated surfaces.2011

    • Author(s)
      Zhang W, Wang H, Oyane A, Tsurushima H, Chu PK
    • Journal Title

      Biomed Mater Eng (in press)

    • NAID

      120007137460

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Control of gene transfer on a DNA-fibronectin-apatite composite layer by the incorporation of carbonate and fluoride ions.2011

    • Author(s)
      Yazaki Y, Oyane A, Sogo Y, Ito A, Yamazaki A, Tsurushima H
    • Journal Title

      Biomaterials (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Newly synthesized radical-containing nanoparticles (RNP) enhance neuroprotection after cerebral ischemia-reperfusion injury.2011

    • Author(s)
      Marushima A, Suzuki K, Nagasaki Y, Yoshitomi_ T, Toh K, Tsurushima H(CA), Hirayama A, Matsumura A.
    • Journal Title

      Neurosurgery

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug Delivery Systemと単色X線を用いた新規放射線療法2011

    • Author(s)
      鶴嶋英夫、黒田隆之助
    • Journal Title

      物理学会誌

      Volume: 80(2) Pages: 120-123

    • NAID

      10027785144

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time-course analysis of brain perfusion single-photon emission computed tomography using a three-dimentional stereotactic region-of-interest template in patients with Moyamoya disease.2011

    • Author(s)
      Marushima H, Tsurushima H(CA), Suzuki K, Nakai Y, Nemoto H, Matsumura A
    • Journal Title

      World Neurosurgery

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoblast differentiation and disinfection induced by nitrogen plasma-treated surfaces.2011

    • Author(s)
      Zhang W, Wang H, Oyane A, Tsurushima H(CA), Chu PK
    • Journal Title

      Biomed Mater Eng.

      Volume: In press

    • NAID

      120007137460

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibronectin-DNA-apatite composite layer for highly efficient and area-specific gene transfer.2010

    • Author(s)
      Oyane A, Murayama M, Yamazaki A, Sogo Y, Ito A, Tsurushima H
    • Journal Title

      J Biomed Mater Res A. 92(3)

      Pages: 1038-1047

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Highly efficient gene transfer system using a lamnin-DNA-apatitie composite layer.2010

    • Author(s)
      Oyane A, Tsurushima H, Ito A
    • Journal Title

      J Gene Med. 12(2)

      Pages: 194-206

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced bone formation using hydroxyapatite ceramic coated with fibroblast growth factor-2.2010

    • Author(s)
      Tsurushima H, Marushima A, Suzuki K, Oyane A, Sogo Y, Nakamura K, Matsumura A, Ito A
    • Journal Title

      Acta Biomater. 6

      Pages: 2751-2759

    • NAID

      120007138070

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳虚血再灌流における酸化ストレス障害と脳保護療法 pH応答性ラジカル含有ナノ粒子 (radical-containing nanoparticle : RNP) の可能性-2010

    • Author(s)
      丸島愛樹、鈴木謙介、長崎幸夫、吉冨徹、藤加珠子、鶴嶋英夫、平山暁、松村明
    • Journal Title

      脳卒中 32(6)

      Pages: 552-558

    • NAID

      10027895635

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳虚血再灌流における酸化ストレス障害と脳保護療法 pH応答性ラジカル含有ナノ粒子(radical-containing nanoparticle : RNP)の可能性-2010

    • Author(s)
      丸島愛樹、鈴木謙介、長崎幸夫、吉冨徹、藤加珠子、鶴嶋英夫、平山暁、松村明
    • Journal Title

      脳卒中

      Volume: 32(6) Pages: 552-558

    • NAID

      10027895635

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibronectin-DNA-apatite compostie layer for highly efficient and area-specific gene transfer.2010

    • Author(s)
      Oyane A, Murayama M, Yamazaki A, Sogo Y, Ito A, Tsurushima H(CA)
    • Journal Title

      J Biomed Mater Res A. 92(3)

      Pages: 1038-1047

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced bone formation using hydroxyapatite ceramic coated with fibroblast growth factor-2.2010

    • Author(s)
      Tsurushima H, Marushima A, Suzuki K, Oyane A, Sogo Y, Nakamura K, Matsumura A, Ito A
    • Journal Title

      Acta Biomater. On line published

    • NAID

      120007138070

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of liposome incorporating doxorubicin with sialyl Lewis X to prevent stenosis after rat carotid artery injury.2009

    • Author(s)
      Tsuruta W, Tsurushima H, Yamamoto T, Suzuki K, Yamazaki N, Matsumura A
    • Journal Title

      Biomaterials 30

      Pages: 118-125

    • NAID

      120007138482

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new approach for hydroxyapatite coating on polymeric materials using laser-induced precursor formation and subsequent aging.2009

    • Author(s)
      Lee BH, Oyane A, Tsurushima H, Shimizu Y, Sasaki T, Koshizaki N
    • Journal Title

      ACS Appl Mater Interfaces 1

      Pages: 1520-1524

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ascorbate-Apatite Composite and Ascorbate-FGF2-Apatite Composite Layers Formed on External Fixation Rods and Their Promoting Effects on Cell Proliferation and Differentiation in vitro.2009

    • Author(s)
      Wang XP, Ito A, Sogo Y, Li X, Tsurushima H, Oyane A
    • Journal Title

      Acta Biomater. 5(7)

      Pages: 2647-2656

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of liposome incorporating doxorubicin with sialyl Lewis X to prevent stenosis after rat carotid artery injury.2009

    • Author(s)
      Tsuruta W, Tsurushima H(CA), Yamamoto T, Suzuki K, Yamazaki N, Matsumura A
    • Journal Title

      Biomaterials 30

      Pages: 118-125

    • NAID

      120007138482

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体機能分子を利用したアパタイト系生体材料の開発2009

    • Author(s)
      大矢根綾子、鶴嶋英夫、十河友、伊藤敦夫、六崎裕高
    • Journal Title

      New Glass、ニューガラスフォーラム

      Pages: 35-42

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Application of liposome incorporating doxorubicin with sialyl Lewis X to prevent stenosis after rat carotid artery injury2009

    • Author(s)
      Tsuruta W, Tsurushima H, et al.
    • Journal Title

      Biomaterials 30

      Pages: 118-125

    • NAID

      120007138482

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] シロシタゾールによる頸動脈新生内膜肥厚抑制効果の検討2010

    • Author(s)
      滝川知司、鶴嶋英夫、中村和弘、鈴木謙介、鶴田和太郎、松村明
    • Organizer
      第26回日本脳神経血管内治療学会学術総会
    • Place of Presentation
      北九州(ミニシポジウム)
    • Year and Date
      2010-11-18
    • Related Report
      2010 Final Research Report
  • [Presentation] シロシタゾールによる頸動脈新生内膜肥厚抑制効果の検討2010

    • Author(s)
      滝川知司、鶴嶋英夫、中村和弘、鈴木謙介、鶴田和太郎、松村明
    • Organizer
      第26回日本脳神経血管内治療学会学術総会(ミニシポジウム)
    • Place of Presentation
      北九州
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性期脳梗塞に対する血管内皮前駆細胞(EPC ; endothelialprogenitor cell)を用いた細胞療法に関する研究2010

    • Author(s)
      中村和弘、鶴嶋英夫
    • Organizer
      第69回日本脳神経外科学会学術総会
    • Place of Presentation
      福岡(シンンポジウム)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] BMP-2遺伝子とフィブロネクチン層を持つ医療材料の開発2010

    • Author(s)
      鶴嶋英夫、Zhang Wei、大矢根綾子、十河友、伊藤敦夫、松村明
    • Organizer
      -骨誘導機能性医療材料-第69回日本脳神経外科学会学術総会
    • Year and Date
      2010-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] BMP-2遺伝子とフィブロネクチン層を持つ医療材料の開発 -骨誘導機能性医療材料-2010

    • Author(s)
      鶴嶋英夫、Zhang Wei、大矢根綾子、十河友、伊藤敦夫、松村明
    • Organizer
      第69回日本脳神経外科学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性期脳梗塞に対する血管内皮前駆細胞(EPC ; endothelialprogenitor cell)を用いた細胞療法に関する研究2010

    • Author(s)
      中村和弘、鶴嶋英夫
    • Organizer
      第69回日本脳神経外科学会学術総会(シンポジウム)
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Highly efficient gene transfer system using a laminin-DNA-apatite composite layer.2010

    • Author(s)
      Tsurushima H, Oyane A, Ito A, Matsumura A
    • Organizer
      第16回日本遺伝子治療学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] リポソームーアパタイト複合層を利用した遺伝子導入システム-リポソーム構成分子の検討-2010

    • Author(s)
      矢崎侑振、大矢根綾子、十河友、伊藤敦夫、山崎淳司、鶴嶋英夫
    • Organizer
      日本セラミック協会年会
    • Year and Date
      2010-03-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Drug Delivery Sstem とLCX-X線を用いた新規組み合わせ治療の可能性2009

    • Author(s)
      鶴嶋英夫
    • Organizer
      産業技術総合研究所計測フロンティア研究部門第19回公開セミナー
    • Place of Presentation
      つくば
    • Year and Date
      2009-12-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Active Targeting Drug Delivery System を用いた血管形成術後再狭窄予防2009

    • Author(s)
      鶴田和太郎, 鶴嶋英夫, 他
    • Organizer
      第34回日本脳卒中学会総会(シンポジウム)
    • Place of Presentation
      島根
    • Year and Date
      2009-03-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 糖鎖修飾リポソームを用いた血管形成術後狭窄予防2009

    • Author(s)
      鶴嶋英夫、鶴田和太郎、鈴木謙介、山本哲哉、山嵜登、松村明
    • Organizer
      つくば医工連携フォーラム2009
    • Place of Presentation
      つくば
    • Year and Date
      2009-01-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖鎖修飾リポソームを用いた血管形成術後狭窄予防2009

    • Author(s)
      鶴嶋英夫, 他
    • Organizer
      つくば医工連携フォーラム2009
    • Place of Presentation
      筑波
    • Year and Date
      2009-01-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] DNA-抗体-アパタイト複合層を利用した遺伝子導入技術の開発2009

    • Author(s)
      矢崎侑振、鶴嶋英夫、大矢根綾子、十河友、山崎淳司、伊藤敦夫
    • Organizer
      第31回日本バイオマテリアル学会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖鎖修飾リポソームを用いた血管形成術後狭窄予防2009

    • Author(s)
      鶴嶋英夫、鶴田和太郎、鈴木謙介、山本哲哉、山嵜登、松村明
    • Organizer
      第31回日本バイオマテリアル学会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Immobilization of cell adhesion protein in DNA-apatitie composite layer to improve gene transfer efficiency on its surface.2009

    • Author(s)
      Oyane A, Tsurushima H, Murayama M, Yamazaki A, Sogo Y, Ito A
    • Organizer
      The 22nd International Symposium on Ceramics in Medicine. BIOCERAMICS 22
    • Place of Presentation
      Daegu (Korea)
    • Related Report
      2010 Final Research Report
  • [Presentation] Control of efficiency of gene transfer on surface of DNA-Fibronectin-Apatite composite layer.2009

    • Author(s)
      Yazaki Y, Oyane A, Tsurushima H, Sogo Y, Ito A, Yamazaki A
    • Organizer
      The 22nd International Symposium on Ceramics in Medicine. BIOCERAMICS 22
    • Place of Presentation
      Daegu (Korea)
    • Related Report
      2010 Final Research Report
  • [Presentation] Osteoblast differentiation induced by Nitrogen plasma-treated polymer surface.2009

    • Author(s)
      Zhang W, Oyane A, Tsurushima H, Ito A, Chu PK
    • Organizer
      The 22nd International Symposium on Ceramics in Medicine. BIOCERAMICS 22
    • Place of Presentation
      Daegu (Korea)
    • Related Report
      2010 Final Research Report
  • [Presentation] FGF-2担持アパタイトによる頭蓋骨形成術の開発応用2009

    • Author(s)
      鶴嶋英夫、鈴木謙介、大矢根綾子、伊藤敦夫、松村明
    • Organizer
      第68回日本脳神経外科学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Healing of Oxidative Stress in Brain on the Occasion of Cerebral Ischemia-Reperfusion.2009

    • Author(s)
      Yoshitomi T, Toh K, Marushima A, Suzuki S, Tsurushima H, Hirayama A, Matsumura A, Nagasaki Y
    • Organizer
      Biomaterials : Biocompatibility/Tissue Engineering, Gordon Research Conferences
    • Place of Presentation
      New Hampshire (USA)
    • Related Report
      2010 Final Research Report
  • [Presentation] ラジカル含有ナノ粒子を用いた脳虚血再潅流モデルラットにおける脳梗塞の抑制2009

    • Author(s)
      藤加珠子、吉冨徹、丸島愛樹、鈴木謙介、鶴嶋英夫、平山暁、松村明、長崎幸夫
    • Organizer
      第62回日本酸化ストレス学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] Active targeting drug delivery systemを用いた血管形成術後再狭窄予防2009

    • Author(s)
      鶴田和太郎、鶴嶋英夫、山本哲哉、鈴木謙介、山嵜登、松村明
    • Organizer
      Stroke2009(第34回日本脳卒中学会総会、第38回日本脳卒中の外科学会、第25回スパズムシンポジウム
    • Place of Presentation
      島根
    • Related Report
      2010 Final Research Report
  • [Presentation] 高分子ミセル化環状ニトロキシラジカル化合物による脳梗塞抑制効果2009

    • Author(s)
      丸島愛樹、鈴木謙介、吉冨徹、藤加珠子、鶴嶋英夫、平山暁、長崎幸夫、松村明
    • Organizer
      Stroke2009(第34回日本脳卒中学会総会、第38回日本脳卒中の外科学会、第25回スパズムシンポジウム)
    • Place of Presentation
      島根
    • Related Report
      2010 Final Research Report
  • [Presentation] Application of Doxorubicin liposome with sialyl Lewis X for the prevention of stenosis after angioplasty in the rat carotid artery2008

    • Author(s)
      Tsurushima H, et al.
    • Organizer
      第57回米国脳神経外科科学会議
    • Place of Presentation
      Orlando in USA
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Book] バイオセラミックルネッサンス2010、バイオマテリアル-生体材料-(Surface-mediated transfection のためのバイオセラミックスの設計と展開) (p109-115)2010

    • Author(s)
      大矢根綾子、鶴嶋英夫、伊藤敦夫
    • Total Pages
      28
    • Related Report
      2010 Final Research Report
  • [Book] バイオセラミックルネッサンス2010、バイオマテリアル-生体材料-2010

    • Author(s)
      大矢根綾子、鶴嶋英夫、伊藤敦夫
    • Publisher
      Surface-mediated transfectionのためのバイオセラミックスの設計と展開
    • Related Report
      2010 Annual Research Report
  • [Book] New Glass、ニューガラスフォーラム(生体機能分子を利用したアパタイト系生体材料の開発)(p35-42)2009

    • Author(s)
      大矢根綾子、鶴嶋英夫、十河友、伊藤敦夫、六崎裕高
    • Total Pages
      24
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks] 取材報道

    • Related Report
      2010 Final Research Report
  • [Remarks] メディカルトリビューン紙2009年5月7日 Vol.42 No.19 p16「Stroke2009 臨床導入を目指した脳卒中に対する先端治療研究を報告:血管形成術後再狭窄予防active targeting DDSに期待」において研究内容が報道された

    • Related Report
      2010 Final Research Report
  • [Remarks] 医学書院/週刊医学界新聞第2828号 2009年4月27日「あらためて今「脳卒中」を知るStroke 2009:最先端治療法の臨床応用」において研究内容が報道された

    • Related Report
      2010 Final Research Report
  • [Remarks] メディカルトリビューン紙 2010年8月19日 VOL.43 NO.33 p36「第26回日本DDS学会ラジカル含有環境応答性ナノ粒子によるDDSを創製」にて研究内容が報道された

    • Related Report
      2010 Final Research Report
  • [Remarks] メディカルトリビューン紙 2010年8月19日 VOL.43 NO.33 p36「第26回日本DDS学会 ラジカル含有環境応答性ナノ粒子によるDDSを創製」にて研究内容が報道された。

    • URL

      http://mtpro.medical-tribune.co.jp/mtnews/2010/M43330362/

    • Related Report
      2010 Annual Research Report
  • [Remarks] 1)第62回日本酸化ストレス学会、優秀演題賞(ポスター賞)受賞、2009年

    • Related Report
      2009 Annual Research Report
  • [Remarks] 2)メディカルトリビューン紙2009年5月7日Vol.42 No.19 p16「Stroke 2009臨床導入を目指した脳卒中に対する先端治療研究を報告:血管形成術後再狭窄予防active targeting DDSに期待」において研究内容が報道された。

    • Related Report
      2009 Annual Research Report
  • [Remarks] 3)医学書院/週刊医学界新聞 第2828号 2009年4月27日「あらためて今「脳卒中」を知るStroke 2009:最先端治療法の臨床応用」におてい研究内容が報道された。

    • Related Report
      2009 Annual Research Report
  • [Remarks] 本研究に関して医学新聞メディカルトリビューン紙より取材を受けた(2009年3月)

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 「骨誘導性生体材料」2010

    • Inventor(s)
      鶴嶋英夫、大矢根綾子、Zhang Wei、伊藤敦夫
    • Industrial Property Rights Holder
      産業技術総合研究所
    • Filing Date
      2010-04-27
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 組織再生用スッキャッフォールド及びその製造方法2010

    • Inventor(s)
      大矢根綾子、鶴嶋英夫、伊藤敦夫、十河友、山崎淳司、矢崎侑振
    • Industrial Property Rights Holder
      産業技術総合研究所
    • Filing Date
      2010-01-08
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 骨誘導性生体材料2010

    • Inventor(s)
      鶴嶋英夫、大矢根綾子、Zhang Wei、伊藤敦夫
    • Industrial Property Rights Holder
      産業技術総合研究所
    • Industrial Property Number
      2010-000559
    • Filing Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 組織再生用スッキャッフォールド及びその製造方法2010

    • Inventor(s)
      大矢根綾子、鶴嶋英夫、伊藤敦夫、十河友、山崎淳司、矢崎侑振
    • Industrial Property Rights Holder
      産業技術総合研究所
    • Industrial Property Number
      2010-003079
    • Filing Date
      2010-01-08
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 「遺伝子及び溶解性制御因子を含む組織再生用スキャッフォールド、及びその製造方法」2009

    • Inventor(s)
      大矢根綾子、鶴嶋英夫、伊藤敦夫、十河友、山崎淳司、矢崎侑振、
    • Industrial Property Rights Holder
      産業技術総合研究所
    • Filing Date
      2009-01-07
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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