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Translational Research for Clinical Application of Autologous Bone Marrow Stromal Cell Transplantation for CNS disorders

Research Project

Project/Area Number 20591701
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionHokkaido University

Principal Investigator

HIDA Kazutoshi  Hokkaido University, 大学院・医学研究科, 准教授 (10238305)

Co-Investigator(Kenkyū-buntansha) KURODA Satoshi  北海道大学, 病院, 講師 (10301904)
SHICHINOHE Hideo  北海道大学, 病院, 助教 (80374479)
IWASAKI Yoshinobu  北海道大学, 大学院・医学研究科, 名誉教授 (00113522)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords神経再生 / 骨髄間質細胞 / 脊髄損傷 / 脳損傷 / 脳梗塞 / 再生医療 / Bane marrow stromal cell / Transplantation / Cerebral infarction / Spinal cord injury / Diffuse axonal injury / Differentiation / Regenerative medicine / Functional restoration / Bone marrow stromal cell / Spinal cord iniury / Diffuse axonal iniury
Research Abstract

For these 3 years, we have run many experiments and explored many new knowledge on autologous bone marrow stromal cell transplantation for central nervous system disorders. We have reported the novel aspects of their biological features and the utility of bioimaging technology such as MRI and optical imaging. This report shows the brief summary of these knowledge.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (123 results)

All 2011 2010 2009 2008 Other

All Journal Article (62 results) (of which Peer Reviewed: 57 results) Presentation (55 results) Book (6 results)

  • [Journal Article] Therapeutic impact of human bone marrow stromal cells (hBMSC) expanded by animal serum-free medium for cerebral infarct in rats.2011

    • Author(s)
      Sugiyama T, Kuroda S, Takeda Y, Nishio M, Ito M, Shichinohe H, Koike T
    • Journal Title

      Neurosurgery Epub ahead of print

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳梗塞再生医療の展望2011

    • Author(s)
      黒田敏、宝金清博
    • Journal Title

      Medical Practice 28

      Pages: 681-684

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Near infrared fluorescence labeling allows noninvasive tracking of bone marrow stromal cells transplanted into rat infarct brain.2011

    • Author(s)
      Sugiyama T, Kuroda S, Osanai T, Shichinohe H, Kuge Y, Ito M, Kawabori M, Iwasaki Y
    • Journal Title

      Neurosurgery Epub ahead of print

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Near infrared fluorescence labeling allows non-invasive tracking of bone marrow stromal cells transplanted into rat infarct brain.2011

    • Author(s)
      Sugiyama T, Kuroda S, et al.
    • Journal Title

      Neurosurgery

      Volume: (In press,In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autologous bone marrow stromal cell transplantation for central nervous system disorders-Recent progress and perspective for clinical application.2011

    • Author(s)
      Kuroda S, et al.
    • Journal Title

      J Stem Cell Regen Med

      Volume: 7 Pages: 1-12

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic impact of human bone marrow stromal cells (hBMSC) expanded by animal serum-free medium for cerebral infarct in rats.2011

    • Author(s)
      Sugiyama T, Kuroda S, et al.
    • Journal Title

      Neurosurgery

      Volume: (In press,In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳卒中に対する骨髄間質細胞移植研究の現状と課題2011

    • Author(s)
      黒田敏, ら
    • Journal Title

      脳卒中

      Volume: 32 Pages: 532-537

    • NAID

      10027895546

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 脳梗塞再生医療の展望2011

    • Author(s)
      黒田敏, ら
    • Journal Title

      Medical Practice

      Volume: (In press,In press)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Pretreatment with the cyclosporine derivative, NIM811, reduces delayed neuronal death in the hippocampus after transient forebrain ischemia.2010

    • Author(s)
      Hokari M, Kuroda S, Iwasaki Y
    • Journal Title

      J Pharm Pharmacol 62

      Pages: 485-490

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-invasive transplantation of bone marrow stromal cell for ischemic stroke: Preliminary study using a thermoreversible gelation polymer (TGP) hydrogel.2010

    • Author(s)
      Osanai T, Kuroda S, Yasuda H, Chiba Y, Maruichi K, Hokari M, Sugiyama T, Shichinohe H, Iwasaki Y
    • Journal Title

      Neurosurgery 66

      Pages: 1140-1147

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice.2010

    • Author(s)
      Hokari M, Kuroda S, Kinugawa S, Ide T, Tsutsui H, Iwasaki Y
    • Journal Title

      Neuropathology 30

      Pages: 401-407

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, Fasudil on axon regeneration in rat spinal cord injury.2010

    • Author(s)
      Chiba Y, Kuroda S, Shichinohe H, Hokari M, Osanai T, Maruichi K, Yano S, Hida K, Iwasaki Y
    • Journal Title

      Neuropathology 30

      Pages: 241-250

    • NAID

      10029320824

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cell transplantation attenuates cognitive dysfunction due to chronic cerebral ischemia in rats.2010

    • Author(s)
      Shichinohe H, Kuroda S, Sugiyama T, Ito M, Kawabori M
    • Journal Title

      Dement Geriatr Cogn Disord 30

      Pages: 293-301

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳梗塞をターゲットとした再生医療における最適な細胞移植法2010

    • Author(s)
      川堀真人、黒田敏、七戸秀夫、宝金清博
    • Journal Title

      再生医療 9

      Pages: 477-486

    • NAID

      120006488412

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳卒中に対する骨髄間質細胞移植研究の現状と課題2010

    • Author(s)
      黒田敏、七戸秀夫、杉山拓、伊東雅基、川堀真人、千葉泰弘、長内俊也、丸一勝彦、宝金清博、岩崎喜信
    • Journal Title

      脳卒中 32

      Pages: 532-537

    • NAID

      10027895546

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 中枢神経再生におけるバイオイメージング2010

    • Author(s)
      杉山拓、伊東雅基、七戸秀夫、黒田敏
    • Journal Title

      再生医療 9

      Pages: 65-71

    • NAID

      40017144131

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biodegradable fibrin scaffold enhances survival, migration and differentiation of transplanted bone marrow stromal cells in cortical freezing injury model of rats.2010

    • Author(s)
      Yasuda H, Kuroda S, Shichinohe H, Kamei S, Kawamura R, Iwasaki Y
    • Journal Title

      J Neurosurg 112

      Pages: 336-344

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biodegradable fibrin scaffold enhances survival, migration and differentiation of transnlanted bone marrow stromal cells in cortical freezing injury model of rats.2010

    • Author(s)
      Yasuda H, Kuroda S, et al.
    • Journal Title

      J Neurosurg

      Volume: 112 Pages: 336-344

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells and bone marrow-derived mononuclear cells-Which are suitable as cell source of transplantation for mice infarct brain?2010

    • Author(s)
      Shichinohe H, Kuroda S, et al.
    • Journal Title

      Neuropathology

      Volume: 30 Pages: 113-122

    • NAID

      10029320219

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice.2010

    • Author(s)
      Hokari M, Kuroda S, et al.
    • Journal Title

      Neuropathology

      Volume: 30 Pages: 401-407

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-invasive transplantation of bone marrow stromal cell for ischemic stroke : Preliminary study using a thermoreversible gelation polymer (TGP) hydrogel.2010

    • Author(s)
      Osanai T, Kuroda S, et al.
    • Journal Title

      Neurosurgery

      Volume: 66 Pages: 1140-1147

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pretreatment with the cyclosporine derivative, NIM811, reduces delayed neuronal death in the hippocampus after transient forebrain ischemia.2010

    • Author(s)
      Hokari M, Kuroda S, et al.
    • Journal Title

      J Pharm Pharmacol

      Volume: 62 Pages: 485-490

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cell transplantation attenuates cognitive dysfunction due to chronic cerebral ischemia in rats.2010

    • Author(s)
      Shichinohe H, Kuroda S, et al.
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 30 Pages: 293-301

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中枢神経再生におけるバイオイメージング2010

    • Author(s)
      杉山拓、黒田敏, ら
    • Journal Title

      再生医療

      Volume: 9 Pages: 65-71

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト骨髄間質細胞の安全で効率的な培養法-骨髄間質細胞移植による中枢神経再生の臨床応用に向けて-2010

    • Author(s)
      伊東雅基、黒田敏, ら
    • Journal Title

      再生医療

      Volume: 9 Pages: 72-79

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳梗塞をターゲットとした再生医療における最適な細胞移植法。2010

    • Author(s)
      川堀真人、黒田敏, ら
    • Journal Title

      再生医療

      Volume: 9 Pages: 477-486

    • NAID

      120006488412

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biodegradable fibrin scaffold enhances survival, migration, and differentiation of transplanted bone marrow…2010

    • Author(s)
      Yasuda H, et al.
    • Journal Title

      J Neurosurg 112

      Pages: 336-344

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-invasive transplantation of bone marrow stromal cells using a thermoreversible gelation polymer(TGP)hydrogel…2010

    • Author(s)
      Osanai T, et al.
    • Journal Title

      Neurosurgery (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中枢神経再生におけるバイオイメージング2010

    • Author(s)
      杉山, ら
    • Journal Title

      再生医療 (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells improves cognitive dysfunction due to diffuse axonal injury in rats.2009

    • Author(s)
      Maruichi K, Kuroda S, Chiba Y, Hokari M, Shichinohe H, Hida K, Iwasaki Y
    • Journal Title

      Neuropathology 29

      Pages: 422-432

    • NAID

      10028191635

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Graded model of diffuse axonal injury for studying head injury-induced cognitive dysfunction in rats.2009

    • Author(s)
      Maruichi K, Kuroda S, Chiba Y, Hokari M, Shichinohe H, Hida K, Iwasaki Y
    • Journal Title

      Neuropathology 29

      Pages: 132-139

    • NAID

      10026608745

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells and bone marrow-derived mononuclear cells -Which are suitable as cell source of transplantation for mice infarct brain?2009

    • Author(s)
      Shichinohe H, Kuroda S, Maruichi K, Osanai T, Sugiyama T, Chiba Y, Yamaguchi A, Iwasaki Y
    • Journal Title

      Neuropathology Epub ahead of print

    • NAID

      10029320219

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat spinal cord injury model.2009

    • Author(s)
      Chiba Y, Kuroda S, Maruichi K, Osanai T, Hokari M, Yano S, Shichinohe H, Hida K, Iwasaki Y
    • Journal Title

      Neurosurgery 64

      Pages: 991-1000

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation for mice cerebral infarct.2009

    • Author(s)
      穂刈正昭, 黒田敏, 千葉泰弘, 丸一勝彦, 岩崎喜信
    • Journal Title

      Cytokine 46

      Pages: 260-266

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cell transplantation for cerebral infarction - recent advances and perspective.2009

    • Author(s)
      七戸秀夫, 黒田敏
    • Journal Title

      Res Adv in Stroke 1

      Pages: 23-35

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into injured spinal cord - A novel material for CNS tissue engineering.2009

    • Author(s)
      Itosaka H, Kuroda S, Shichinohe H, Yasuda H, Yano S, Kamei S, Kawamura R, Hida K, Iwasaki Y
    • Journal Title

      Neuropathology 29

      Pages: 248-257

    • NAID

      10026609224

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Graded model of diffuse axonal injury for studying head Injury-induced cognitive dysfunction in rats.2009

    • Author(s)
      Maruichi K, et al.
    • Journal Title

      Neuropathology 29

      Pages: 132-139

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells improve cognitive dysfunction due to diffuse axonal injury in rats2009

    • Author(s)
      Maruichi K, et al.
    • Journal Title

      Neuropathology(E-pub) 29

      Pages: 422-432

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat…2009

    • Author(s)
      Chiba Y, et al.
    • Journal Title

      Neurosurgery 64

      Pages: 991-1000

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation…2009

    • Author(s)
      Hokari M, et al.
    • Journal Title

      Cytokine 46

      Pages: 260-266

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells & bone marrow mononuclear cells -Which are suitable as cell source of transplantation…2009

    • Author(s)
      Shichinohe H, et al.
    • Journal Title

      Neuropathology(E-pub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of bone marrow stromal cells and a Rhokinase(ROCK)inhibitor, Fasudil on axon…2009

    • Author(s)
      Chiba Y, et al.
    • Journal Title

      Neuropathology(E-pub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into…2009

    • Author(s)
      Itosaka H, et al.
    • Journal Title

      Neuropathology 29

      Pages: 248-257

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells improve cognitiye dysfunction due to diffuse axonal injury in rats2009

    • Author(s)
      Maruichi K, et.al.
    • Journal Title

      Neuropathology (E-pub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biodegradable fibrin scaffold enhances survival, migration, and differentiation of transplanted bone marrow2009

    • Author(s)
      Yasuda H, et.al.
    • Journal Title

      J Neurosurg (E-pub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of granulocyte-colony stimulating fact or on bone marrow stromal cell transplantation2009

    • Author(s)
      okari M, et.al.
    • Journal Title

      Cytokine (E-pub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cell transplantation for cerebral infarction-recent advances and perspective2009

    • Author(s)
      Shichinohe H, et.al.
    • Journal Title

      Res Adv in Stroke 1

      Pages: 23-35

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨髄間質細胞を用いた損傷脊髄の再生2009

    • Author(s)
      千葉泰弘ら
    • Journal Title

      リハビリテーション医学 45

      Pages: 356-360

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 中枢神経再生におけるバイオマテリアルの役割2009

    • Author(s)
      長内俊也, ら
    • Journal Title

      再生医療 7

      Pages: 77-82

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラボから急性期脳梗塞治療ヘ-ラジカルスカベンジャーと骨髄間質細胞移植2009

    • Author(s)
      黒田敏
    • Journal Title

      脳卒中 30

      Pages: 875-879

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Edaravone (MCI-186) scavenges reactive oxygen species and ameliorates tissue damage in mice spinal cord injury model.2008

    • Author(s)
      Aoyama T, Hida K, Kuroda S, Seki T, Yano S, Shichinohe H, Iwasaki Y
    • Journal Title

      Neurol Med Chir (Tokyo) 48

      Pages: 539-545

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells differentiate into neurons and promote axon elongation in spinal cord slice cultures: Their role in cell transplantation therapy for spinal cord injury.2008

    • Author(s)
      Shichinohe H, Kuroda S, Tsuji S, Yamaguchi S, Yano S, Lee JB, Kobayashi H, Hokari M, Hida K, Kikuchi S, Iwasaki Y
    • Journal Title

      Neurorehabil Neural Repair 22

      Pages: 447-457

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells protect and repair damaged neurons through multiple mechanisms.2008

    • Author(s)
      Hokari M, Kuroda S, Shichinohe H, Yano S, Hida K, Iwasaki Y
    • Journal Title

      J Neurosci Res 86

      Pages: 1024-1035

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨髄間質細胞を用いた損傷脊髄の再生2008

    • Author(s)
      千葉泰弘、黒田敏、穂刈正昭、矢野俊介、飛騨一利、岩崎喜信
    • Journal Title

      リハビリテーション医学 45

      Pages: 356-360

    • NAID

      110006792789

    • Related Report
      2010 Final Research Report
  • [Journal Article] 中枢神経再生におけるバイオマテリアルの役割2008

    • Author(s)
      長内俊也、黒田敏、岩崎喜信
    • Journal Title

      再生医療 7

      Pages: 77-82

    • NAID

      40016387509

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ラボから急性期脳梗塞の治療へーラジカルスカベンジャーと骨髄細胞移植2008

    • Author(s)
      黒田敏
    • Journal Title

      脳卒中 30

      Pages: 875-879

    • NAID

      10024937358

    • Related Report
      2010 Final Research Report
  • [Journal Article] Bone marrow stromal cells protect and repair damaged neurons through multiple mechanisms2008

    • Author(s)
      Hokari M, et.al.
    • Journal Title

      J Neurosci Res 86

      Pages: 1024-1035

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Graded model of diffuse axonal injury for studying head Injury-induced cognitive dysfunction in rats2008

    • Author(s)
      Maruichi K, et.al.
    • Journal Title

      Neuropathology (E-pub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells differentiate into neurons And promote axon elongation in spinal cord slice2008

    • Author(s)
      Shichinohe H, et.al.
    • Journal Title

      Neurorehabil Neural Repair 22

      Pages: 447-457

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibrin matrix provides a suitable scaffold for bone mar row stromal cells transplanted into2008

    • Author(s)
      Itosaka H, et.al.
    • Journal Title

      Neuropathology (E-pub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Edaravone (MCI186) scavenges reactive oxygen species and ameliorates tissue damaffe in mice spinal cord2008

    • Author(s)
      Aoyama T, et.al.
    • Journal Title

      Neurol Med Chir (Tokyo) 48

      Pages: 539-545

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat

    • Author(s)
      Chiba Y, et.al.
    • Journal Title

      Neurosurgery (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Platelet lysateを用いたヒト骨髄間質細胞培養-安全な中枢神経再生の臨床応用を目指して2011

    • Author(s)
      七戸秀夫、黒田敏, ら
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臨床用MRIを用いた鉄製剤で標識された骨髄間質細胞のファントム内検出2011

    • Author(s)
      七戸秀夫、黒田敏, ら
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨髄間質細胞移植による脳卒中予防効果-発症前SHR-SPにおけるneuro-vascular unitの保護および脳損傷の軽減2011

    • Author(s)
      伊東雅基、黒田敏, ら
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット脳凍結損傷モデルに対する骨髄間質細胞の経動脈的移植-生体蛍光イメージング法による評価2011

    • Author(s)
      長内俊也、黒田敏, ら
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳梗塞ラットモデルに対するBMSC移植の投与経路に関しての検討2011

    • Author(s)
      川堀真人、黒田敏, ら
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transplanted Bone Marrow Stromal Cells Protect Neurovascular Units and Ameliorate Brain Damage in Stroke-Prone Spontaneously Hypertensive Rats (SHR-SP)2011

    • Author(s)
      Ito M, Kuroda S, et al.
    • Organizer
      国際脳卒中会議2011
    • Place of Presentation
      Convention Center(ロサンゼルス、USA)
    • Year and Date
      2011-02-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳神経外科疾患に対する骨髄間質細胞移植研究の現状と課題2010

    • Author(s)
      黒田敏, ら
    • Organizer
      第69回日本脳神経外科学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Serial Magnetic Resonance Tracking of Human Bone Marrow Stromal Cells Transplanted into Infarct Brain of Rats - Validity of Cell Expansion in Animal Serum-Free Medium2010

    • Author(s)
      Ito M, et al.
    • Organizer
      第60回米国神経外科コングレス
    • Place of Presentation
      San Franciso
    • Year and Date
      2010-10-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Direct or Intravenous Delivery of Bone Marrow Stromal Cells - Which is Better Route for Ischemic Stroke?2010

    • Author(s)
      Kawabori M, et al.
    • Organizer
      第60回米国神経外科コングレス
    • Place of Presentation
      San Franciso
    • Year and Date
      2010-10-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Direct or Intravenous Delivery of Bone Marrow Stromal Cells-Which is Better Route for Ischemic Stroke?2010

    • Author(s)
      Kawabori M, Kuroda S, et al.
    • Organizer
      第60回米国神経外科コングレス
    • Place of Presentation
      Moscone West Convention Center(サンフランシスコ、USA)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Serial Magnetic Resonance Tracking of Human Bone Marrow Stromal Cells Transplanted into Infarct Brain of Rats-Validity of Cell Expansion in Animal Serum-Free Medium2010

    • Author(s)
      Ito M, Kuroda S, et al.
    • Organizer
      第60回米国神経外科コングレス
    • Place of Presentation
      Moscone West Convention Center(サンフランシスコ、USA)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Optimal delivery route of bone marrow stromal cells for rat infarct brain-A study using non-invasive optical imaging2010

    • Author(s)
      Kawabori M, Kuroda S, et al.
    • Organizer
      第5回日印再生医療研究会
    • Place of Presentation
      Severa Hotel(チェンナイ、インド)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transplantation of autologous bone marrow stromal cells (BMSC) for CNS disorders-Strategy and tactics for clinical application2010

    • Author(s)
      Kuroda S, et al.
    • Organizer
      第5回日印再生医療研究会
    • Place of Presentation
      Severa Hotel(チェンナイ、インド) 招待講演
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題2010

    • Author(s)
      黒田敏, ら
    • Organizer
      第35回日本脳卒中学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Animal serumfree mediumで培養したヒト骨髄間質細胞の脳梗塞治療における有用性 - in vivo study2010

    • Author(s)
      杉山拓、黒田敏, ら
    • Organizer
      第35回日本脳卒中学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Allimal serum-free mediumで培養したヒト骨髄間質細胞の脳梗塞治療における有用性-in vivo study2010

    • Author(s)
      杉山拓、黒田敏, ら
    • Organizer
      第35回日本脳卒中学会
    • Place of Presentation
      岩手県民会館(盛岡)
    • Year and Date
      2010-04-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] もやもや病の発症におけるendothelial progenitor cells (EPC)の役割;病理学的検討2010

    • Author(s)
      杉山拓、黒田敏, ら
    • Organizer
      第35回日本脳卒中学会
    • Place of Presentation
      岩手県民会館(盛岡)
    • Year and Date
      2010-04-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題2010

    • Author(s)
      黒田敏, ら
    • Organizer
      第35回日本脳卒中学会
    • Place of Presentation
      岩手県民会館(盛岡)
    • Year and Date
      2010-04-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨髄間質細胞におる中枢神経再生の治療戦略2010

    • Author(s)
      黒田敏, ら
    • Organizer
      第10回脳血管疾患治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略2010

    • Author(s)
      黒田敏
    • Organizer
      第10回脳血管疾患治療研究会
    • Place of Presentation
      東京都、如水会館
    • Year and Date
      2010-02-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳梗塞の病態と外科治療2010

    • Author(s)
      黒田敏, ら
    • Organizer
      第3回脳卒中撲滅講演会
    • Place of Presentation
      奈良
    • Year and Date
      2010-01-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳梗塞の病態と外科治療2010

    • Author(s)
      黒田敏
    • Organizer
      第3回脳卒中撲滅講演会
    • Place of Presentation
      奈良市、奈良ホテル
    • Year and Date
      2010-01-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性脳循環不全+骨髄間質細胞移植モデルにおける記憶学習障害の改善2010

    • Author(s)
      七戸秀夫, ら
    • Organizer
      第9回日本再生医療学会
    • Place of Presentation
      広島
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルにおける治療効果の検討2010

    • Author(s)
      杉山拓, ら
    • Organizer
      第9回日本再生医療学会
    • Place of Presentation
      広島
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット脳梗塞モデルへの骨髄間質細胞の最適な移植経路2010

    • Author(s)
      川堀真人, ら
    • Organizer
      第9回日本再生医療学会
    • Place of Presentation
      広島
    • Related Report
      2010 Final Research Report
  • [Presentation] Bone marrow stromal cell transplantation for chronic cerebral ischemia model2010

    • Author(s)
      七戸秀夫, et al.
    • Organizer
      Internatonal Stroke Conference 2010
    • Place of Presentation
      San Antonio, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット脳梗塞モデルへの骨髄間質細胞の最適な移植経路2010

    • Author(s)
      川堀真人, ら
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島市、広島国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルへの移植2010

    • Author(s)
      伊東雅基, ら
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島市、広島国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルにおける治療効果の検討2010

    • Author(s)
      杉山拓, ら
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島市、広島国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性脳循環不全・骨髄間質細胞移植モデルにおける記憶学習障害の改善2010

    • Author(s)
      七戸秀夫, ら
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島市、広島国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bone marrow stromal cell transplantation for chronic cerebral ischemia2010

    • Author(s)
      Shichinohe H, et al
    • Organizer
      International Stroke Conference 2010
    • Place of Presentation
      San Antonio(USA), Convention Center
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨髄間質細胞におる中枢神経再生の治療戦略2009

    • Author(s)
      黒田敏, ら
    • Organizer
      第9回ブレインアタックカンファレンス研究会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略2009

    • Author(s)
      黒田敏
    • Organizer
      第9回ブレインアタックカンファレンス研究会
    • Place of Presentation
      福岡市、西鉄グランドホテル
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨髄間質細胞におる中枢神経再生の治療戦略2009

    • Author(s)
      黒田敏, ら
    • Organizer
      第12回浜松脳神経障害とフリーラジカル研究会
    • Place of Presentation
      浜松
    • Year and Date
      2009-07-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略2009

    • Author(s)
      黒田敏
    • Organizer
      第12回浜松脳神経障害とフリーラジカル研究会
    • Place of Presentation
      浜松市、オークラアクトシティホテル浜松
    • Year and Date
      2009-07-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mitochondrial transcription factor Aは虚血による神経細胞障害を軽減する2009

    • Author(s)
      穂刈正昭, ら
    • Organizer
      日本脳循環代謝学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 自己骨髄細胞による損傷脊髄の再生2009

    • Author(s)
      黒田敏, ら
    • Organizer
      日本脊髄障害医学会総会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat spinal cord injury2009

    • Author(s)
      千葉泰弘, et al.
    • Organizer
      American Association of Neurological Surgeons
    • Place of Presentation
      Chicago
    • Related Report
      2010 Final Research Report
  • [Presentation] Transplanted bone marrow stromal cells improve cognitive dysfunction due to diffuse axonal injury in rats2009

    • Author(s)
      丸一勝彦, et al.
    • Organizer
      American Association of Neurological Surgeons
    • Place of Presentation
      Chicago
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題2009

    • Author(s)
      黒田敏, ら
    • Organizer
      日本脳卒中学会
    • Place of Presentation
      松江
    • Related Report
      2010 Final Research Report
  • [Presentation] Bone marrow stromal cell transplantation for central nervous system disorders2009

    • Author(s)
      黒田敏, et al.
    • Organizer
      International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      Sapporo
    • Related Report
      2010 Final Research Report
  • [Presentation] 長波長蛍光物質で標識した骨髄間質細胞の頭蓋内光イメージング2009

    • Author(s)
      杉山拓, ら
    • Organizer
      日本再生医療学会
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 骨髄間質細胞の移植はびまん性軸策損傷による高次脳機能障害を改善する2009

    • Author(s)
      丸一勝彦, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨髄間質細胞移植のバイオマテリアルとしてのMebiol gelの有用性について2009

    • Author(s)
      長内俊也, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 塩酸ファスジルは脊髄損傷に対する骨髄間質細胞の移植効果を増強するか?2009

    • Author(s)
      千葉泰弘, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] STA-MCA anastomosis and EDMAPS for moyamoya disease2009

    • Author(s)
      Kuroda S, et al
    • Organizer
      9^<th> International Conference for Cerebrovascular Surgery(ICCVS)
    • Place of Presentation
      名古屋市、ウェスティンナゴヤキャッスル
    • Related Report
      2009 Annual Research Report
  • [Presentation] 塩酸ファスジルは脊髄損傷に対する骨髄間質細胞の移植効果を増強するか?2009

    • Author(s)
      千葉泰弘, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨髄間質細胞移植のバイオマテリアルとしてのMebiol gelの有用性について2009

    • Author(s)
      長内俊也, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨髄間質細胞の移植はびまん性軸策損傷による高次脳機能障害を改善する2009

    • Author(s)
      丸一勝彦, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題2009

    • Author(s)
      黒田敏, ら
    • Organizer
      日本脳卒中学会
    • Place of Presentation
      島根県民会館、松江市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Bone marrow stromal cell transplantation for central ne rvous system disorders2009

    • Author(s)
      Kuroda S, et.al.
    • Organizer
      International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      Hokkaido University, Sannoro
    • Related Report
      2008 Annual Research Report
  • [Presentation] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat2008

    • Author(s)
      Chiba Y, et.al.
    • Organizer
      American Association of Neurological Surgeons
    • Place of Presentation
      McCormick Place, Chicago
    • Related Report
      2008 Annual Research Report
  • [Presentation] Transplanted bone marrow stromal cells improve cognitive dysfunction due to diffuse axonal iniury in rats2008

    • Author(s)
      Maruichi K, et.al.
    • Organizer
      American Association of Neurological Surgeons
    • Place of Presentation
      McCormick Place, Chicago
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mitochondrial transcription factor Aは虚血による神経細胞障害を軽減する2008

    • Author(s)
      穂刈正昭, ら
    • Organizer
      日本脳循環代謝学会
    • Place of Presentation
      東京ドームホテル、東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 自己骨髄細胞による損傷脊髄の再生2008

    • Author(s)
      黒田敏
    • Organizer
      日本脊髄障害医学会総会
    • Place of Presentation
      かでる2.7、札幌
    • Related Report
      2008 Annual Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development(Tamaki N and Kuge Y (ed))(Transplanted bone marrow stromal cells improves cognitive dysfunction due to diffuse axonal injury in rats.)2010

    • Author(s)
      Maruichi K, Kuroda S, Chiba Y, Osanai T, Sugiyama T, Hokari M, Hida K, Iwasaki Y
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development(Tamaki N and Kuge Y (ed))(Beneficial effects of bone marrow stromal cell transplantation on axonal regeneration in injured spinal cord.)2010

    • Author(s)
      Chiba Y, Kuroda S, Maruichi K, Osanai T, Hokari M, Yano S, Shichinohe H, Hida K, Iwasaki Y
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development(Tamaki N and Kuge Y (ed))(Thermoreversible gelation polymer (TGP) hydrogel as a degradable scaffold for bone marrow stromal cell transplantation.)2010

    • Author(s)
      Osanai T, Kuroda S, Yasuda H, Chiba Y, Maruichi K, Hokari M, Sugiyama T, Shichinohe H, Iwasaki Y
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development(Tamaki N and Kuge Y (ed))(Non-invasive optical tracking of bone marrow stromal cells transplanted into rat cerebral infarct.)2010

    • Author(s)
      Sugiyama T, Kuroda S, Osanai T, Maruichi K, Chiba Y, Shichinohe H, Kuge Y, Tamaki N, Iwasaki Y
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development(Tamaki N and Kuge Y (ed))(Bone marrow stromal cell transplantation for central nervous system disorders - Perspective for translational research and clinical application.)2010

    • Author(s)
      Kuroda S, Kuge Y, Tamaki N, Iwasaki Y
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development2010

    • Author(s)
      Tamaki N, Kuge Y, et al
    • Total Pages
      303
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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