Analysis of a particle with membrane fusion protein for boron neutron capture therapy

• Project/Area Number: 20591705
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: University of Tsukuba
• Principal Investigator: NAKAI Kei University of Tsukuba, 大学院・人間総合科学研究科, 講師 (50436284)
• Co-Investigator(Kenkyū-buntansha): MATSUMURA Akira 筑波大学, 大学院・人間総合科学研究科, 教授 (90241819) ; YAMAMOTO Tetsuya 筑波大学, 大学院・人間総合科学研究科, 講師 (30375505)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ホウ素 / リポソーム / 中性子 / 悪性脳腫瘍 / 膜融合 / リボソーム

Research Abstract

The Boron Neutron Capture Therapy (BNCT) has been used clinically for the treatment of malignant tumors. Two drugs, p-boronophenylalanine (BPA) and the sulfhydral borane (BSH) have been used. We developed the new boron delivery system with Liposome encapsulated Boron compounds, borono-porphyrin, and vesicle with membrane fusion proteins. Cell boron concentration was measured. The results showed this delivery system could be applicable for BNCT.

Research Products

• [Journal Article] Feasibility of Boron Neutron Capture Therapy for malignant spinal tumors. (2009)
  • Author(s): Nakai K, Kumada H, Yamamoto T, Tsurubuchi T, Zaboronok A, Matsumura A
  • Journal Title: Appl Radiat Isot 67(7-8 Suppl)
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of a novel liposome containing BPA-peptide conjugate for BNCT. (2009)
  • Author(s): Shirakawa M, Yamamoto T, Nakai K, Aburai K, Kawatobi S, Tsurubuchi T, Yamamoto Y, Yokoyama Y, Okuno H, Matsumura A
  • Journal Title: Appl Radiat Isot
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma. (2009)
  • Author(s): Yamamoto T, Nakai K, Kageji T, Kumada H, Endo K, Matsuda M, Shibata Y, Matsumura A
  • Journal Title: Radiother Oncol 91 Pages: 80-84
  • NAID: 120007138272
  • Peer Reviewed
• [Journal Article] Combined use of sodium borocaptate and buthionine sulfoximine in boron neutron capture therapy enhanced tissue boron uptake and delayed tumor growth in a rat subcutaneous tumor model. (2008)
  • Author(s): Yoshida F, Yamamoto T, Nakai K, Kumada H, Shibata Y, Tsuruta W, Endo K, Tsurubuchi T, Matsumura A
  • Journal Title: Cancer letters 263 Pages: 253-8
  • Peer Reviewed
• [Presentation] Development of a functional liposome modified a novel lipid analog for BNCT. (2010)
  • Author(s): Shirakawa M, Yamamoto T, Nakai K, Matsumura A, et al
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-29
• [Presentation] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma. (2010)
  • Author(s): Nakai K, Yamamoto T, Matsumura A, et al.
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-28
• [Presentation] JRR-4 facility for animal irradiation experiments. (2010)
  • Author(s): Endo K, Yamamoto T, Nakai K, et al.
  • Organizer: 14th lnternational congress on neutron. 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-28
• [Presentation] JRR-4 facility for animal irradiation experiments、14th International congress on nentron. (2010)
  • Author(s): Endo K, Yamamoto T, Nakai K, et al
  • Organizer: 14th International congress on neutran capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-28
• [Presentation] 中性子捕捉療法のための新規ホウ素リポソームの開発 (2009)
  • Author(s): 中井啓、松村明, ほか
  • Organizer: 第68回日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-15
• [Presentation] 中性子捕捉療法のための新規ホウ素リポソームの開発 (2009)
  • Author(s): 中井啓, ほか
  • Organizer: 第68回 日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-14
• [Presentation] 初発神経膠芽腫に対する中性子捕捉療法 (2009)
  • Author(s): 中井啓、山本哲哉、松村明, ほか
  • Organizer: 第6回日本中性子捕捉療法学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-09-20
• [Presentation] 膜透過性ペプチド修飾ポソートのBNCTへの展開 (2009)
  • Author(s): 白川真
  • Organizer: 第6回 日本中性子捕捉寮法学会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-19
• [Presentation] Intracellular uptake of a new boronated porphyrin ECO32. Proceedings of 13th International Congress of Neutron Capture Therapy (2008)
  • Author(s): Tsurubuchi T, Yamamoto T, Nakai K, Yoshida F, Miyakawa M, Shirakawa M, Ueno M, Matsuda M, Nakae Y, Asano R, Matsumura A
  • Organizer: 13th International Congress of Neutron Capture Therapy
  • Place of Presentation: Florence,Italy
  • Year and Date: 2008-11-08
• [Presentation] Synthesis and evaluation of a novel lipisome containing BPA-peptide conjugate for BNCT. (2008)
  • Author(s): Shirakawa M, Yamamoto T, Nakai K, Aburai K, Kawatobi S, Tsurubuchi T, Yamamoto Y, Aokoyama Y, Okuno H, Matsumura A
  • Organizer: 13th International Congress of Neutro Capture Therapy
  • Place of Presentation: Florence, Italy
  • Year and Date: 2008-11-03
• [Presentation] Synthesis and evaluation of a novel liposome containing BPA-peptide conjugate for BNCT (2008)
  • Author(s): 白川真,山本哲哉,中井啓,鶴淵隆夫,油井研,横山裕作,奥野洋明,松村明
  • Organizer: 第5回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 倉敷
  • Year and Date: 2008-07-25
• [Presentation] 新規ホウ素ポルフィリンEC032のホウ素濃度測定方法及び細胞内とりこみに関する研究. (2008)
  • Author(s): 鶴淵隆夫,山本哲哉,中井啓,吉田文代,白川真,上野学,松田真秀,浅野龍二,仲江良則,松村明
  • Organizer: 第5回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 倉敷
  • Year and Date: 2008-07-25
• [Presentation] Development of Boron Nano-Capsules for Neutron Capture Therapy (invited lecture) (2008)
  • Author(s): Nakai K, Nakamura H, Lee C, Yasufumi K, Matsumura A.
  • Organizer: The particle 2008.
  • Place of Presentation: Orlando(USA)
  • Year and Date: 2008-05-12
• [Presentation] Development of Boron Nano-Capsules for Neutron Capture Therapy (2008)
  • Author(s): Nakai K, Nakamura H, Lee C, Yasufumi K, Matsumura A.
  • Organizer: The particle 2008
  • Place of Presentation: Orlando, USA
  • Year and Date: 2008-05-11
• [Book] ホウ素中性子捕捉療法(NS NOW 5グリオーマその最新治験) (2009)
  • Author(s): 松村明、中井啓
  • Publisher: メジカルビュー社
• [Book] 「DIGITAL MEDICINE」第7巻第6号(ホウ素中性子捕捉療法(BNCT)の現状とこれからの展開) (2009)
  • Author(s): 松村明、中井啓