| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
The aim of this project was to identify key molecules among genes named as Substitute for EGFR* Expression (SE*Es) which are presumed to contribute to the resistance against therapy for malignant glioma, and to clarify their functions. First we categorized clinical specimens of malignant gliomas into basic subclasses based on genetic analyses and established several cell lines of brain tumor stem-like cells. Then to detect whether expressions of SE*E genes are elevated in human malignant gliomas and brain tumor stem-like cells, we investigated genomic amplification and gene expression in these tumor samples and consequently could pick up potentially important candidate genes which are subjected to further analyses.
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