| Project/Area Number |
20591714
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
KURATSU Jun-ichi (2009-2010) Kumamoto University, 大学院・生命科学研究部, 教授 (20145296)
浜崎 禎 (2008) Kumamoto University, 医学部附属病院, 助教 (60433033)
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| Co-Investigator(Kenkyū-buntansha) |
MORIOKA Motohiro 熊本大学, 大学院・生命科学研究部, 准教授 (20295140)
YAMADA Kazumichi 熊本大学, 医学部附属病院, 特任准教授 (00398215)
倉津 純一 熊本大学, 医学薬学研究部, 教授 (20145296)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳深部刺激術 / 神経細胞新生 / マイクロアレイ / パーキンソン病 / ジストニア / 運動異常症 / 脳深音刺激術 / マクロアレイ |
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| Research Abstract |
Mechanisms underlying clinical effect of deep brain stimulation (DBS) are still unclear ; however, DBS may act through neuronal reorganization of the brain. By using animal model, we found that description factor Pax6 is expressed in the surrounding structure of subthalamic nucleus (STN) and may become a useful marker for neuronal regeneration subsequent to DBS. In human subjects with Parkinson's disease, effect of STN-DBS was significantly correlated to white matter volume, suggesting preserved connectivity between components of the basal ganglia-thalamocortical circuit may be required for the effectiveness of electrical stimulation. We continue to study to establish a stable animal model for STN-DBS to detect whether DBS substantially induces neuronal regeneration in the mammalian brain.
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