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Deep brain stimulation and neuronal reorganization

Research Project

Project/Area Number 20591714
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKumamoto University

Principal Investigator

KURATSU Jun-ichi (2009-2010)  Kumamoto University, 大学院・生命科学研究部, 教授 (20145296)

浜崎 禎 (2008)  Kumamoto University, 医学部附属病院, 助教 (60433033)

Co-Investigator(Kenkyū-buntansha) MORIOKA Motohiro  熊本大学, 大学院・生命科学研究部, 准教授 (20295140)
YAMADA Kazumichi  熊本大学, 医学部附属病院, 特任准教授 (00398215)
倉津 純一  熊本大学, 医学薬学研究部, 教授 (20145296)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脳深部刺激術 / 神経細胞新生 / マイクロアレイ / パーキンソン病 / ジストニア / 運動異常症 / 脳深音刺激術 / マクロアレイ
Research Abstract

Mechanisms underlying clinical effect of deep brain stimulation (DBS) are still unclear ; however, DBS may act through neuronal reorganization of the brain. By using animal model, we found that description factor Pax6 is expressed in the surrounding structure of subthalamic nucleus (STN) and may become a useful marker for neuronal regeneration subsequent to DBS. In human subjects with Parkinson's disease, effect of STN-DBS was significantly correlated to white matter volume, suggesting preserved connectivity between components of the basal ganglia-thalamocortical circuit may be required for the effectiveness of electrical stimulation. We continue to study to establish a stable animal model for STN-DBS to detect whether DBS substantially induces neuronal regeneration in the mammalian brain.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (32 results)

All 2011 2010 2009 2008

All Journal Article (18 results) (of which Peer Reviewed: 13 results) Presentation (14 results)

  • [Journal Article] GPi-pallidal stimulation for Lance-Adams syndrome2011

    • Author(s)
      Yamada K, SakuramaT, SoyamaN, Kuratsu J
    • Journal Title

      Neurology 76

      Pages: 1270-1272

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 不随意運動症に対する定位脳手術とその治療ターゲット(2)2011

    • Author(s)
      山田和慶、長谷川雄、倉津純一
    • Journal Title

      脳神経外科速報 21

      Pages: 64-71

    • Related Report
      2010 Final Research Report
  • [Journal Article] 不随意運動症に対する定位脳手術とその治療ターゲット(1)2010

    • Author(s)
      山田和慶、長谷川雄、倉津純一
    • Journal Title

      脳神経外科速報 20

      Pages: 1405-1411

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cardiac 123I-MIBG scintigraphy as an outcome-predicting tool for subthalamic nucleus stimulation in Parkinson's disease2010

    • Author(s)
      Yamada K, Shiraishi S, Hamasaki T, Kuratsu J
    • Journal Title

      Acta Neurochir.(Wien) 152

      Pages: 2063-2068

    • NAID

      120003674319

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] White mater volume in Parkinson disease-A predictive factor for response to subthalamic stimulation-2010

    • Author(s)
      Hamasaki T, Yamada K, Hirai T, Kuratsu J.
    • Journal Title

      Acta eurochir (Wien) 152

      Pages: 997-1006

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] GPi-pallidal stimulation to treat generalized dystonia in Cockayne syndrome2010

    • Author(s)
      Hamasaki K, Yamada K, Hamasaki T, Kuratsu J
    • Journal Title

      Mov Disord 25

      Pages: 656-658

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] GPi-pallidal stimulation to treat generalized dystonia in Cockaynesyndrome2010

    • Author(s)
      Kiyotoshi Hamasaki, Kazumichi Yamada, Tadashi Hamasaki, Jun-ichi kuratsu
    • Journal Title

      Movoment Disorders

      Volume: 25 Pages: 656-658

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] White mater volume in Parkinson disease -A predictive factor for response to subthalamic stimulation-2010

    • Author(s)
      Tadashi Hamasaki, Kazumichi Yamada, Toshinori Hirai, Jun-ichi Kuratsu
    • Journal Title

      Acta Neurochirurgica(Wien)

      Volume: 152 Pages: 997-1006

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac ^<123>I-MIBG scintigraphy as an outcome-predicting tool for subthalamic nucleus stimulation in Parkinson's disease2010

    • Author(s)
      Kazumichi Yamda, Shin-ya Shiraishi, Tadashi Hamasaki, Jun-ichi Kuratsu
    • Journal Title

      Acta Neurochirurgica(Wien)

      Volume: 152 Pages: 2063-2068

    • NAID

      120003674319

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不随意運動症に対する定位脳手術とその治療ターゲット(1)2010

    • Author(s)
      仙田和慶、長谷川雄、倉津純一
    • Journal Title

      脳神経外科速報

      Volume: 21(招待論文) Pages: 1405-1411

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 虚血後ミオクローヌス(Lance-Adams症候群)に対する淡蒼球内節刺激術2010

    • Author(s)
      櫻間智孝, 山田和慶, 曾山直宏, 等泰之, 高島大輝, 倉津純一
    • Journal Title

      機能的脳神経外科

      Volume: 49 Pages: 56-57

    • NAID

      10029745278

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Subthalamic nucleus stimulation applied in the earlier vs. advanced stage of Parkinson's disease -Retrospective evaluation of postoperative independence in pursuing daily activities-2009

    • Author(s)
      Yamada K, Hamasaki T, Kuratsu J
    • Journal Title

      Parkinsonism Relat Disord 15

      Pages: 746-751

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subthalamic nucleus stimulation applied in the earlier vs. advanced stage of Parkinson's disease-retrospective evaluation of postoperative independence in pursuing daily activities2009

    • Author(s)
      山田和慶, 浜崎禎, 倉津純一
    • Journal Title

      Parkinsonism Relat Disord 15(10)

      Pages: 746-751

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] パーキンソン病における視床下核刺激術と脳白質量の関連性2009

    • Author(s)
      浜崎禎, 山田和慶, 平井俊範, 倉津純一
    • Journal Title

      機能的脳神経外科 48

      Pages: 117-123

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Hemidystonia secondary to thalamic hemorrhage treated with GPi stimulation2008

    • Author(s)
      Hamasaki, T., Yamada, K.Kuratsu J
    • Journal Title

      Mov Disord 23

      Pages: 1762-1766

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bilateral subthalamic nucleus stimulation for levodopa-unresponsive axial symptoms in Parkinson's disease2008

    • Author(s)
      Yamada K, Goto S, Hamasaki T, Kuratsu J
    • Journal Title

      Acta Neurochir (Wien) 150

      Pages: 15-22

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Concurrent hemichorea and migrainous aura -A perfusion study on the basal ganglia using xenon-computed tomography2008

    • Author(s)
      Yamada K, Harada M, Inoue N, Yoshida S, Morioka M, Kuratsu J
    • Journal Title

      Mov Disord 23

      Pages: 425-429

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemidystonia secondary to thalamic hemorrhage treated with GPi stimulation.2008

    • Author(s)
      Hamasaki T
    • Journal Title

      Movement Disorders 23(12)

      Pages: 1762-1766

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 慢性難治性疼痛に対する機能神経外科治療の長期予後評価におけるPainVsionの意義2011

    • Author(s)
      山田和慶
    • Organizer
      第50回日本定位・機能神経外科学会
    • Place of Presentation
      広島、ANAクラウンプラザホテル広島
    • Year and Date
      2011-01-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 大脳皮質運動野刺激術後上肢の二次性ジストニアに改善が見られた1例2011

    • Author(s)
      浜崎禎、山田和慶
    • Organizer
      第50回日本定位・機能神経外科学会
    • Place of Presentation
      ANAクラウンプラザホテル広島(広島)
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性難治性疹痛に対する機能神経外科治療の長期予後評価におけるPainVisionの意義2011

    • Author(s)
      山田和慶
    • Organizer
      第50回日本定位・機能神経外科学会
    • Place of Presentation
      ANAクラーウンプラザホテル広島(広島)
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高齢パーキンソン症例に対する両側視床下核刺激術の効果と問題点2010

    • Author(s)
      山田和慶、倉津純一
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡、マリンメッセ福岡
    • Year and Date
      2010-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 高齢パーキンソン病症例に対する両側視床下核刺激術の効果と問題点2010

    • Author(s)
      山田和慶
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 心筋123I-MIBG シンチグラフィーはパーキンソン病における視床下核刺激術の治療効果を予測する2010

    • Author(s)
      山田和慶、倉津純一
    • Organizer
      第49回日本定位・機能神経外科学会
    • Place of Presentation
      大阪、千里ライフサイエンスセンター
    • Year and Date
      2010-01-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 虚血後ミオクローヌス(Lance-Adams症候群)に対する淡蒼球内節刺激術2010

    • Author(s)
      櫻間智孝、山田和慶、倉津純一
    • Organizer
      第49回日本定位・機能神経外科学会
    • Place of Presentation
      大阪、千里ライフサイエンスセンター
    • Year and Date
      2010-01-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 心筋123I-MIBGシンチグラフィーはパーキンソン病における視床下核刺激術の治療効果を予測する2010

    • Author(s)
      山田和慶, 白石慎哉, 等泰之, 浜崎禎, 倉津純一
    • Organizer
      第49回日本定位・機能神経外科学会
    • Place of Presentation
      大阪、千里ライフサイエンスセンター
    • Year and Date
      2010-01-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 両側淡蒼球内節凝固術治療歴のあるパーキンソン病症例に対する両側視床下核刺激術2009

    • Author(s)
      山田和慶、倉津純一
    • Organizer
      第68回日本脳神経外科学会総会
    • Place of Presentation
      東京、京王プラザホテル
    • Year and Date
      2009-10-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 視床痛に対する内包後脚刺激術の長期効果2009

    • Author(s)
      山田和慶、倉津純一
    • Organizer
      第48回日本定位・機能神経外科学会
    • Place of Presentation
      東京
    • Year and Date
      2009-01-25
    • Related Report
      2010 Final Research Report
  • [Presentation] パーキンソン病における脳白質量と視床下核刺激術の効果の関連性-Voxel based morphometryによる解析-2009

    • Author(s)
      浜崎禎、山田和慶、倉津純一
    • Organizer
      第48回日本定位・機能神経外科学会
    • Place of Presentation
      東京、東京ステーションコンファレンス
    • Year and Date
      2009-01-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Cockayne症候群に伴う全身性ジストニアに対する両側淡蒼球内節刺激術2009

    • Author(s)
      濱崎清利、山田和慶、倉津純一
    • Organizer
      第48回日本定位・機能神経外科学会
    • Place of Presentation
      東京、東京ステーションコンファレンス
    • Year and Date
      2009-01-24
    • Related Report
      2010 Final Research Report
  • [Presentation] パーキンソン病における振戦は視床下核刺激術後のADLに影響するか?2008

    • Author(s)
      山田和慶、倉津純一
    • Organizer
      第67回日本脳神経外科学会総会
    • Place of Presentation
      盛岡、岩手県民会館
    • Year and Date
      2008-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] パーキンソン病における脳白質量と視床下核刺激術の効果の関連性2008

    • Author(s)
      浜崎禎
    • Organizer
      第67回日本脳神経外科学会総会
    • Place of Presentation
      森岡市
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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