Evaluation of chemosensitivity in malignant gliomas : quantitative assessment of serum molecular marker.

• Project/Area Number: 20591719
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Saitama Medical University
• Principal Investigator: ADACHI Junichi 埼玉医科大学, 医学部, 講師 (70291143)
• Co-Investigator(Kenkyū-buntansha): NISHIKAWA Ryo 埼玉医科大学, 医学部, 教授 (90237678) ; MATSUTANI Masao 埼玉医科大学, 医学部, 教授 (90010454)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: グリオーマ / 脳腫瘍 / MGMT / テモゾロミド / メチル化

Research Abstract

Establishment of quantitative assessment of O^6-methylguanine-DNA methyltransferase(MGMT) promoter methylation, which is prognostic and chemosensitive molecular marker in high-grade gliomas. Gliomas with MGMT methylation less than 40% showed significantly short progression-free survival. The frequency of MGMT promoter methylation in newly diagnosed pediatric glioma, regardless tumor grades, was lower than the proportion seen in adult glioma.

Research Products

• [Journal Article] O^6-methylguanine-DNA methyltransferase promoter methylation in 45 primary central nervous system lymphomas : quantitative assessment of methylation and response to temozolomide treatment (2012)
  • Author(s): Adachi J, Mishima K, Wakiya K, Suzuki T, Fukuoka K, Yanagisawa T, Matsutani M, Sasaki A, Nishikawa R
  • Journal Title: J Neurooncol Volume: 107 Pages: 147-153
  • Peer Reviewed
• [Journal Article] SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans (2011)
  • Author(s): Liu KW, Feng H, Bachoo R, Kazlauskas A, Smith EM, Symes K, Hamilton RL, Nagane M, Nishikawa R, Hu B, Cheng SY
  • Journal Title: J Clin Invest Volume: 121 Pages: 905-917
  • Peer Reviewed
• [Journal Article] Methylation-sensitive high-resolution melting analysis : Quantitative assessment of MGMT promoter methylation in high-grade gliomas (2010)
  • Author(s): Adachi J, Totake K, Mishima K, Suzuki T, Wakiya K, Yanagisawa T, Matsutani M and Nishikawa R
  • Journal Title: Neuro-Oncology Volume: 12 Pages: 31-31
  • Peer Reviewed
• [Journal Article] Metronomic chemotherapy with daily oral etoposide for recurrent refractory germ cell tumours (2010)
  • Author(s): Yanagisawa T, Suzuki T, Fukuoka K, Wakiya K, Adachi J, Mishima K, Matsutani M, Fujimaki T, Nishikawa R
  • Journal Title: Neuro-Oncology Volume: 12 Pages: 107-107
  • Peer Reviewed
• [Journal Article] Methylation-sensitive high-resolution melting analysis : Quantitative assessment of MGMT promoter methylation in high-grade gliomas (2010)
  • Author(s): 安達淳一
  • Journal Title: Neuro-Oncology Volume: 12巻 Pages: 31-31
  • Peer Reviewed
• [Journal Article] 乏突起膠腫の診断と治療反応性の予測に有用な分子マーカーの探索 (2009)
  • Author(s): 安達淳一、西川亮、松谷雅生
  • Journal Title: 埼玉医科大学雑誌 Volume: 36(1) Pages: 56-59
• [Journal Article] テモゾロミドによるグリオーマ治療 (2009)
  • Author(s): 西川亮
  • Journal Title: Brain and Nerve Volume: 61(7) Pages: 849-854
• [Journal Article] A multicenter phase I trialof interferon-beta and temozolomide combination therapy for high-gradegliomas(INTEGRA Study) (2008)
  • Author(s): Wakabayashi T, Kayama T, Nishikawa R, Takahashi H, Yoshimine T, Hashimoto N, Aoki T, Kurisu K, Natsume A, Ogura M, Yoshida J
  • Journal Title: Jpn J Clin Oncol Volume: 38(10) Pages: 715-718
  • Peer Reviewed
• [Journal Article] Podocalyxin expression in malignant astrocytic tumors (2008)
  • Author(s): Hayatsu N, Kaneko MK, Mishima K, Nishikawa R, Matsutani M, Price JE, Kato Y
  • Journal Title: Biochem Biophys Res Commun Volume: 374(2) Pages: 394-398
  • Peer Reviewed
• [Journal Article] Association of p16 homozygous deletions with clinicopathological characteristics and EGFR/KRAS/p53 mutations in lung adenocarcinoma (2008)
  • Author(s): Iwakawa R, Kohno T, Anami Y, Noguchi M, Suzuki K, Matsuno Y, Mishima K, Nishikawa R, Tashiro F, Yokota J
  • Journal Title: J. Clin Cancer Res Volume: 14(12) Pages: 3746-3753
  • Peer Reviewed
• [Journal Article] Increased expression of highly sulfated keratan sulfate synthesized in malignant astrocytic tumors (2008)
  • Author(s): Kato Y, Hayatsu N, Kaneko MK, Ogasawara S, Hamano T, Takahashi S, Nishikawa R, Matsutani M, Mishima K, Narimatsu H
  • Journal Title: Biochem Biophys Res Commun Volume: 369(4) Pages: 1041-1046
  • Peer Reviewed
• [Presentation] MGMT promoter methylation status in newly diagnosed pediatric gliomas (2011)
  • Author(s): Adachi J
  • Organizer: 16th annual scientific meeting of the society for neuro-oncology
  • Place of Presentation: Orange County, California, USA
  • Year and Date: 2011-11-09
• [Presentation] MGMT promoter methylation status in newly diagnosed pediatric gliomas (2011)
  • Author(s): Adachi J
  • Organizer: 8th meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: Suzhou, China
  • Year and Date: 2011-05-27
• [Presentation] Treatment of central nervous system lymphomas with temozolomide-preliminary results with MGMT promotor methylation status (2011)
  • Author(s): Nishikawa R
  • Organizer: 8th meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: Suzhou, China
  • Year and Date: 2011-05-27
• [Presentation] Methylation-sensitive high resolution melting analysis : Quantitative assessment of MGMT promoter methylation in high-grade gliomas (2010)
  • Author(s): Adachi J
  • Organizer: 9th Meeting of The European Association of Neuro-Oncology
  • Place of Presentation: Maastricht, Netherlands
  • Year and Date: 2010-09-17
• [Presentation] Methylation-sensitive high resolution melting analysis : a new quantitative assessment of MGMT promoter methylation in high-grade gliomas (2010)
  • Author(s): 安達淳一
  • Organizer: 第9回欧州脳腫瘍学会
  • Place of Presentation: マーストリヒト(オランダ)
  • Year and Date: 2010-09-17
• [Presentation] Methylation-sensitive high resolution melting analysis : a new quantitative assessment of MGMT promoter methylation in gliomas (2009)
  • Author(s): Adachi J
  • Organizer: The 3rd Quadrennial Meeting of the World Federation of Neuro-Oncology
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2009-05-14
• [Presentation] Methylation-sensitive high-resolution melting analysis : a new quantitative assessment of MGMT promoter methylation in gliomas (2009)
  • Author(s): 安達淳一
  • Organizer: 第3回 世界脳腫瘍学会
  • Place of Presentation: パフィコ横浜(神奈川県)
  • Year and Date: 2009-05-14
• [Presentation] メチル化感受性高解像能融解曲線分析法に基づくMGMT遺伝子メチル化の定量的解析 (2008)
  • Author(s): 安達 淳一
  • Organizer: 第26回 日本脳腫瘍学会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2008-11-30