Effect of radiosurgery on the neurovascular endothelial cells.
| Project/Area Number |
20591720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyorin University |
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Principal Investigator |
KURITA Hiroki Kyorin University, 医学部, 准教授 (70262003)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Toshiki 杏林大学, 医学部, 助教 (90406968)
YAMAGUCHI Ryuichi 杏林大学, 医学部, 助教 (20439194)
SHIOKAWA Yoshiaki 杏林大学, 医学部, 教授 (20245450)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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|---|
| Keywords | 脳動静脈奇形 / radiosurgery / 血管内皮細胞 / PKC / GFAP / 放射線障害 / 脳血流 / 血管構築 / radiosurgey |
|---|
| Research Abstract |
To clarify the biological effect of radiosurgery (single high-dose irradiation), we investigated morphological and physiological change of neurovascular endothelial cells. Irradiation induced activation of both protein kinese C (PKC) and vascular endotherial growth factor (VEGF), which resulted in impaired tight gap junction of endothelium and contributed to brain edema.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article]2009
Author(s)
栗田浩樹、塩川芳昭
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Journal Title
VI疾患別各論7.脳動静脈奇形.神経疾患最新の治療2009-2011(南江堂)
Pages: 100-102
Related Report
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[Journal Article] Functional carotid artery trapping and reconstruction with radial artery graft for ruptured carotid blister-like aneurysms of the anterior wall : long-term results2008
Author(s)
Kurita H, Shiokawa Y, Yamaguchi R, Seyama H, Nishiyama K, Yamada S, Momma H, Matsumoto Y, Shimotomai Y, Kato M, Yamaguchi Y
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Journal Title
J Stroke Cerebrovasc Dis 17巻
Pages: 90-91
Related Report
Peer Reviewed
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