| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
To clarify the biological effect of radiosurgery (single high-dose irradiation), we investigated morphological and physiological change of neurovascular endothelial cells. Irradiation induced activation of both protein kinese C (PKC) and vascular endotherial growth factor (VEGF), which resulted in impaired tight gap junction of endothelium and contributed to brain edema.
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