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Effect of radiosurgery on the neurovascular endothelial cells.

Research Project

Project/Area Number 20591720
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKyorin University

Principal Investigator

KURITA Hiroki  Kyorin University, 医学部, 准教授 (70262003)

Co-Investigator(Renkei-kenkyūsha) IKEDA Toshiki  杏林大学, 医学部, 助教 (90406968)
YAMAGUCHI Ryuichi  杏林大学, 医学部, 助教 (20439194)
SHIOKAWA Yoshiaki  杏林大学, 医学部, 教授 (20245450)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords脳動静脈奇形 / radiosurgery / 血管内皮細胞 / PKC / GFAP / 放射線障害 / 脳血流 / 血管構築 / radiosurgey
Research Abstract

To clarify the biological effect of radiosurgery (single high-dose irradiation), we investigated morphological and physiological change of neurovascular endothelial cells. Irradiation induced activation of both protein kinese C (PKC) and vascular endotherial growth factor (VEGF), which resulted in impaired tight gap junction of endothelium and contributed to brain edema.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (58 results)

All 2011 2010 2009 2008

All Journal Article (20 results) (of which Peer Reviewed: 15 results) Presentation (31 results) Book (7 results)

  • [Journal Article] 乳児期に破裂したAVMの1例2011

    • Author(s)
      新田勇介、栗田浩樹、宮崎寛、塩川芳昭
    • Journal Title

      脳卒中 33巻

      Pages: 135-139

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] イラストでばっちり学べる脳神経外科手術くも膜下出血(1)クリッピング術2010

    • Author(s)
      竹田理子、栗田浩樹
    • Journal Title

      Brain Nursing 26巻

      Pages: 10-13

    • Related Report
      2010 Final Research Report
  • [Journal Article] 慢性期にposterior petrosal approachでclippingした破裂BA-AICA動脈瘤の一例2010

    • Author(s)
      福田信、栗田浩樹、塩川芳昭
    • Journal Title

      脳神経外科速報 20巻

      Pages: 835-840

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiosurgery for cerebral arteriovenous malformation during regnancy : a case reort focusing on fetal exposure to radiations.2010

    • Author(s)
      Nagayama K, Kurita H, Tonari A, Takayama M, Shiokawa Y
    • Journal Title

      Asian J Neurosurg 11巻

      Pages: 73-77

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] symmetrical cerebral arteriovenous malformations in bilateral basal ganglia2010

    • Author(s)
      Nagayama K, Kurita H
    • Journal Title

      Cerebrovasc Dis 29巻

      Pages: 4120-4120

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 重量破裂脳動脈瘤急性期治療の実際とその成績について2010

    • Author(s)
      栗田浩樹、佐藤栄志、塩川芳昭
    • Journal Title

      脳外誌 19巻

      Pages: 126-132

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] rt-PA時代の超急性期脳梗塞の画像診断で把握しておくべきガイドライン2010

    • Author(s)
      栗田浩樹
    • Journal Title

      臨床画像 26巻

      Pages: 366-371

    • Related Report
      2010 Final Research Report
  • [Journal Article] Radiosurgery for cerebral arteriovenous malformation during regnancy2010

    • Author(s)
      Kurita H
    • Journal Title

      Asian J Neurosurg

      Volume: 11 Pages: 73-77

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] symmetrical cerebral arteriovenous malformations in bilateral basal ganglia2010

    • Author(s)
      Kurita H
    • Journal Title

      Cerebrovasc Dis

      Volume: 29 Pages: 412-413

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 乳児期に破裂したAVM2010

    • Author(s)
      栗田浩樹
    • Journal Title

      脳卒中

      Volume: 33 Pages: 135-139

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Symmetrical cerebral arteriovenous malformations.2010

    • Author(s)
      Nagayama K, Kurita H
    • Journal Title

      Cerebrovascular Disease 29

      Pages: 412-412

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 重症破裂脳動脈瘤急性期治療の実際とその成績について.2010

    • Author(s)
      栗田浩樹、佐藤栄志、塩川芳昭
    • Journal Title

      脳神経外科ジャーナル 19

      Pages: 126-132

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly diagnosed glioblastoma-analysis of 06-methylguanine-DNA methyltransferase status2009

    • Author(s)
      Nagane M, Nozue K, Shimizu S, Waha A, Miyazaki H, Kurita H, Homori M, Fujioka Y, Shiokawa Y
    • Journal Title

      J Neurooncol 92巻

      Pages: 227-232

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 急性期破裂脳動脈瘤の治療選択の現状(第1報)2009

    • Author(s)
      塩川芳昭、栗田浩樹、藤井清孝
    • Journal Title

      脳卒中の外科 37

      Pages: 1-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      栗田浩樹、塩川芳昭
    • Journal Title

      VI疾患別各論7.脳動静脈奇形.神経疾患最新の治療2009-2011(南江堂)

      Pages: 100-102

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Analysis of clinical outcome of aneurismal subarachnoid hemorrhage : a single institusion experience with 1268 patients2008

    • Author(s)
      Kurita H, Shiokawa Y, Yamaguchi R, Seyama H, Nishiyama K, Yamada S, Matsumoto Y, Shimotomai Y, Niina Y, Yamaguchi Y
    • Journal Title

      Int J Stroke 3巻

      Pages: 412-413

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional carotid artery trapping and reconstruction with radial artery graft for ruptured carotid blister-like aneurysms of the anterior wall : long-term results2008

    • Author(s)
      Kurita H, Shiokawa Y, Yamaguchi R, Seyama H, Nishiyama K, Yamada S, Momma H, Matsumoto Y, Shimotomai Y, Kato M, Yamaguchi Y
    • Journal Title

      J Stroke Cerebrovasc Dis 17巻

      Pages: 90-91

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳動脈瘤手術における血行再建術の応用-適応と治療成績について2008

    • Author(s)
      栗田浩樹、山口竜一、池田俊貴、原田洋一、塩川芳昭
    • Journal Title

      脳卒中の外科 36巻

      Pages: 271-276

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 若年者の脳出血-脳動静脈奇形を中心に2008

    • Author(s)
      栗田浩樹
    • Journal Title

      分子脳血管病 7巻

      Pages: 39-43

    • Related Report
      2010 Final Research Report
  • [Journal Article] 麻痺と感覚障害の画像診断2008

    • Author(s)
      栗田浩樹
    • Journal Title

      臨床リハ 17巻

      Pages: 15-19

    • Related Report
      2010 Final Research Report
  • [Presentation] AVM手術の基本手技とバリエーション:脳血管外科医が目指すもの2011

    • Author(s)
      栗田浩樹
    • Organizer
      横浜市立大学脳神経外科講演会
    • Place of Presentation
      横浜
    • Year and Date
      2011-02-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Surgical salvage for symptomatic degenerate AVMs after radiosurgery : an update.2011

    • Author(s)
      栗田浩樹
    • Organizer
      4^<th> World ICH Conference
    • Place of Presentation
      NewcastleGateshead, UK
    • Related Report
      2010 Final Research Report
  • [Presentation] AVMのバリエーションと基本手技2011

    • Author(s)
      栗田浩樹
    • Organizer
      第20回脳神経外科手術と機器学会
    • Place of Presentation
      徳島
    • Related Report
      2010 Final Research Report
  • [Presentation] Salvage surgery for symptomatic degenerate AVMs after radiosurgery : an update.2011

    • Author(s)
      Kurita H
    • Organizer
      4^<th> International Winter Neurosurgical Congress
    • Place of Presentation
      Rusutsu Resort, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] 破裂AVMに対する急性期手術:適応、手術手技、治療成績とpitfallについて2011

    • Author(s)
      栗田浩樹
    • Organizer
      第16回日本脳神経外科救急学会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] Radiosurgery時代におけるAVMの外科治療戦略と手術手技2010

    • Author(s)
      栗田浩樹
    • Organizer
      第3回NMS Neurosurgery update
    • Place of Presentation
      東京
    • Year and Date
      2010-03-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Symptomatic degenerate AVMs after radiosurgery : clinical presentations, surgical salvage, and etiological considerations.2010

    • Author(s)
      Kurita H
    • Organizer
      8^<th> Asian Congress of Neurological Surgeons
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Related Report
      2010 Final Research Report
  • [Presentation] 直達術を行った前頭蓋底硬膜動静脈奇形症例の検討:適確なshunt point extirpationのために2010

    • Author(s)
      竹田理々子
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] Symptomatic degenerate AVMs after radiosurgery : clinical presentations, surgical salvage, and etiological considerations.2010

    • Author(s)
      栗田浩樹
    • Organizer
      7^<th> World Stroke Congeress
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] Symptomatic degenerate AVMs after radiosurgery : clinical presentations, surgical salvage, and etiological considerations.2010

    • Author(s)
      栗田浩樹
    • Organizer
      XIX European Stroke Conference
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Final Research Report
  • [Presentation] AVM手術の基本と合併症回避のポイント2010

    • Author(s)
      栗田浩樹
    • Organizer
      第30回日本脳神経外科コングレス総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Symptomatic degenerate AVMs after radiosurgery : clinical presentations, surgical salvage, and etiological considerations2010

    • Author(s)
      Kurita H
    • Organizer
      8th Asian Congress of Neurological Surgeons
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Related Report
      2010 Annual Research Report
  • [Presentation] AVMに対する外科治療戦略と手術手技について2009

    • Author(s)
      栗田浩樹
    • Organizer
      第68回札幌脳外科集談話会
    • Place of Presentation
      札幌
    • Year and Date
      2009-11-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 胃癌からの脳転移病変に対する定位的放射線治療2009

    • Author(s)
      永山和樹
    • Organizer
      第18回日本定位的放射線治療学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-07-17
    • Related Report
      2010 Final Research Report
  • [Presentation] AVM手術における術中echoの有用性について2009

    • Author(s)
      栗田浩樹
    • Organizer
      第58回関東脳神経外科懇話会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 直達術で治療した高齢者の硬膜動静脈奇形の一例2009

    • Author(s)
      栗田浩樹
    • Organizer
      第22回日本老年脳神経外科学会
    • Place of Presentation
      広島
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Urgent/Early surgery for ruptured cerebral arteriovenous malformations : Technical aspects and surgical results.2009

    • Author(s)
      栗田浩樹
    • Organizer
      The 9^<th> International Conference on Cerebrovascular Surgery (ICCVS 2009).
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] 出血で発症したEloquent area AVMの急性期手術手技-Surgical management of eloquent area AVMs : Technical aspects and clinical results.2009

    • Author(s)
      栗田浩樹
    • Organizer
      第68回日本脳神経外科学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 救命救急・脳卒中センターにおける破裂AVMの臨床像と急性期外科治療2009

    • Author(s)
      栗田浩樹
    • Organizer
      第34回日本脳卒中学会総会・第38回日本脳卒中の外科学会総会
    • Place of Presentation
      松江
    • Related Report
      2010 Final Research Report
  • [Presentation] 破裂AVMに対する急性期手術のポイント2009

    • Author(s)
      栗田浩樹
    • Organizer
      第25回白馬脳神経外科セミナー
    • Place of Presentation
      八方尾根
    • Related Report
      2010 Final Research Report
  • [Presentation] 救命救急・脳卒中センターにおける破裂AVMの臨床像と急性期外科治療2009

    • Author(s)
      栗田浩樹、塩川芳昭, ほか
    • Organizer
      第34回日本脳卒中学会総会
    • Place of Presentation
      松江
    • Related Report
      2009 Annual Research Report
  • [Presentation] 出血で発症したEloquent area AVMの急性期手術2009

    • Author(s)
      栗田浩樹、塩川芳昭, ほか
    • Organizer
      第68回日本脳神経外科学会総会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 静脈性梗塞で発症した完全血栓化AVMの1例2008

    • Author(s)
      平岩直也
    • Organizer
      第107回日本脳神経外科学会関東支部会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-13
    • Related Report
      2010 Final Research Report
  • [Presentation] AVMの外科治療戦略2008

    • Author(s)
      栗田浩樹
    • Organizer
      第100回日本脳神経外科学会九州支部会
    • Year and Date
      2008-09-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 破裂AVMに対する急性期手術2008

    • Author(s)
      栗田浩樹
    • Organizer
      第67回日本脳神経外科学会総会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Final Research Report
  • [Presentation] Update of surgical technique on ruptured cerebral arteriovenous malformations.2008

    • Author(s)
      栗田浩樹
    • Organizer
      The 9th Japanese & Korean Friendship Conference on Surgery for Cerebral Stroke (JKFC)
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] 破裂脳動静脈奇形の急性期手術のポイント2008

    • Author(s)
      栗田浩樹
    • Organizer
      第17回脳神経外科手術を機器学会
    • Place of Presentation
      長崎
    • Related Report
      2010 Final Research Report
  • [Presentation] 破裂AVMに対する急性期手術2008

    • Author(s)
      栗田浩樹
    • Organizer
      第37回日本脳卒中の外科学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 救命救急センターにおける破裂AVMの臨床像と急性期治療2008

    • Author(s)
      栗田浩樹
    • Organizer
      第33回日本脳卒中学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] Treatment of ruptured anterior chroidal artery aneurysms : 12-year experience with 20 cases.2008

    • Author(s)
      Yamaguchi R
    • Organizer
      The 5^<th> Asia Pacific Conference Against Stroke
    • Place of Presentation
      Pasig City, Philippines
    • Related Report
      2010 Final Research Report
  • [Presentation] Acute Craniotomy for hemorrhagic intracranial arteriovenous malformations : Technical aspects and clinical results.2008

    • Author(s)
      栗田浩樹
    • Organizer
      The 5^<th> Asia Pacific Conference Against Stroke
    • Place of Presentation
      Pasig City, Philippines
    • Related Report
      2010 Final Research Report
  • [Book] A脳血管障害の急性期治療.EBM脳神経外科疾患の治療2010-20112010

    • Author(s)
      杉山達也、大井川秀聡、栗田浩樹
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] III-7脳動静脈奇形.神経疾患最新の治療2009-20112010

    • Author(s)
      栗田浩樹
    • Publisher
      南江堂
    • Related Report
      2010 Final Research Report
  • [Book] 神経疾患最新の治療2009-20112010

    • Author(s)
      栗田浩樹
    • Publisher
      脳動静脈奇形
    • Related Report
      2010 Annual Research Report
  • [Book] VII章:ガンマナイフ.聴神経腫瘍(佐々木富男編)2009

    • Author(s)
      栗田浩樹
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] 脳虚血治療のなかのrt-PA静注療法の位置づけ-riskとbenefit.即活用!rt-PA静注療法実践マスターガイド適応・診断・管理のコツ2009

    • Author(s)
      栗田浩樹
    • Publisher
      MedicalView社
    • Related Report
      2010 Final Research Report
  • [Book] VI疾患別各論<脳疾患>7.脳動静脈奇形.神経疾患最新の治療2009-20112008

    • Author(s)
      栗田浩樹、塩川芳昭
    • Publisher
      南江堂
    • Related Report
      2010 Final Research Report
  • [Book] 各論IV.血管障害3.脳動静脈奇形.臨床研修医のための画像医学教室脳神経領域2008

    • Author(s)
      栗田浩樹
    • Publisher
      医療科学社
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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