Towards molecular classification and individualized treatment of gliomas
| Project/Area Number |
20591721
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
SASAKI Hikaru Keio University, 医学部, 講師 (70245512)
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| Co-Investigator(Kenkyū-buntansha) |
HIROSE Yuichi 藤田保健衛生大学, 医学部, 教授 (60218849)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Kazunari 慶應義塾大学, 医学部, 教授 (70166940)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脳腫瘍学 / 遺伝子 / 癌 / 神経膠腫 / グリオーマ / 1p / 19q / neoadjuvant / 個別化治療 / 脳・神経 / glioma / lp |
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| Research Abstract |
We have prospectively conducted, on a daily basis, molecular studies on all resected gliomas including CGH and methylation-specific PCR of the MGMT gene. As a result, we found that adult supratentorial grade 2-3 gliomas are divided into clinically relevant subgroups by genetic profile (Hirose, 2011), and that single-copy gain of chromosome 1q is frequent in pediatric gliomas, and is associated with poor clinical outcome (Miwa, 2011). Moreover, we have treated 21 1p/19q-codeleted gliomas by neoadjuvant approach, and, of them, second-look removal after chemotherapeutic response was performed in 8 cases. There has been no recurrence in those tumors, and our results suggest efficacy of neoadjuvant approach for chemosensitive gliomas.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Whole genome analysis from microdissected tissue revealed adult supratentorial grade II-III gliomas are divided into clinically relevant subgroups by genetic profile.2011
Author(s)
Hirose Y, Sasaki H, Miwa T, Ohba S, Ikeda E, Abe M, Ikeda S, Kobayashi M, Kawase T, Hasegawa M, Yoshida K
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Journal Title
Neurosurgery 原著 (Epub ahead of print)
Related Report
Peer Reviewed
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[Presentation] Neoadjuvant approach for gliomas2010
Author(s)
Sasaki H, Hirose Y, Katayama M, Yoshida K, Ohira T, Kawase T
Organizer
18th International conference on brain tumor research and therapy
Place of Presentation
Travemunde, Germany (口演)
Year and Date
2010-05-20
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