Quantitative spectral analysis of 5-ALA derived porphyrin fluorescence and auto-fluorescence for improving PDD
| Project/Area Number |
20591729
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
KUROIWA Toshihiko Osaka Medical College, 医学部, 教授 (30178115)
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| Co-Investigator(Kenkyū-buntansha) |
KAJIMOTO Yoshinaga 大阪医科大学, 医学部, 講師 (30224413)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 光線力学診断 / 脳腫瘍 / グリオーマ / スペクトル解析 / アミノレブリン酸 / 5-アミノレブリン酸 / 光線力学治療 / 神経膠芽腫 |
|---|
| Research Abstract |
As for the photodynamic diagnosis using 5-ALA, the judgments of fluorescence intensity is not quantitative but subjective by naked eyes. Therefore, the precision of diagnosis is still limited. In this study, we newly developed the quantitative spectral analysis method for fluorescence derived form 5-ALA induced porphyrin and brain tissue using spectroradiometer. We applied this methods for clinical samples and could quantitatively measure fluorescence as spectral radiance, which SI unit is W^*sr^<-1*>m^<-2*>nm^<-1>. We confirmed the relationship between fluorescence radiance and clinical properties, such as ordinal judgment of fluorescent intensity and enzyme level of porphyrin synthesis.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article]2009
Author(s)
梶本宜永
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Journal Title
NS-NOW 5 グリオーマ「その最新知見」(Medical View)
Pages: 112-115
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