• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of the effects of tumor microenvironment on the susceptibility of malignant tumors to anticancer drugs-its therapeutic application

Research Project

Project/Area Number 20591731
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionShimane University

Principal Investigator

TAKENAGA Keizo  Shimane University, 医学部, 准教授 (80260256)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脳腫瘍 / 薬剤抵抗性 / 微小環境 / アストロサイト / アストロサイ
Research Abstract

To examine whether tumor microenvironment (e.g., astrocytes and hypoxia) influence the susceptibility of glioblastoma and metastatic brain tumors to anticancer drugs, we tested cytotoxic activity of various anticancer agents against rat and human glioma cells and human mammary carcinoma cells in cocultures with rat astrocytesunder normoxic and hypoxic conditions. The results showed that temozolomide (TMZ) becomes less effective against glioma cells and metastatic brain tumor cells in the presence of astrocytes, which depends not on cellular interactions or soluble factors such as inflammatory cytokines but primarily on the ability of astrocytes to reduce the efficacy of TMZ.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2011 2010 Other

All Journal Article (1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Angiogenic signaling aberrantly induced by tumor hypoxia.2011

    • Author(s)
      Takenaga K.
    • Journal Title

      Front Biosci. 16

      Pages: 31-48

    • Related Report
      2010 Final Research Report
  • [Presentation] Decreasein chemosensitivity to temozolomide in glioma cells co-cultured with astrocytes.2010

    • Author(s)
      Takenaga K, Akimoto M, Honma Y.
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Decrease in chemosensitivity to temozolomide in glioma cells co-cultured with astrocytes.2010

    • Author(s)
      Takenaga K, Akimoto M, Honma Y.
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi