Analysis of the effects of tumor microenvironment on the susceptibility of malignant tumors to anticancer drugs-its therapeutic application
| Project/Area Number |
20591731
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Shimane University |
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Principal Investigator |
TAKENAGA Keizo Shimane University, 医学部, 准教授 (80260256)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳腫瘍 / 薬剤抵抗性 / 微小環境 / アストロサイト / アストロサイ |
|---|
| Research Abstract |
To examine whether tumor microenvironment (e.g., astrocytes and hypoxia) influence the susceptibility of glioblastoma and metastatic brain tumors to anticancer drugs, we tested cytotoxic activity of various anticancer agents against rat and human glioma cells and human mammary carcinoma cells in cocultures with rat astrocytesunder normoxic and hypoxic conditions. The results showed that temozolomide (TMZ) becomes less effective against glioma cells and metastatic brain tumor cells in the presence of astrocytes, which depends not on cellular interactions or soluble factors such as inflammatory cytokines but primarily on the ability of astrocytes to reduce the efficacy of TMZ.
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Report
(4 results)
Research Products
(4 results)
