Regulation of cell cycle in nucleus pulposus cells for the treatment of intervertebral disc degeneration
| Project/Area Number |
20591733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
SUDO Hideki Hokkaido University, 大学院・医学研究科, 特任講師 (30374367)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 整形外科 / 脊椎外科 / 椎間板 / 細胞周期 / 再生医学 |
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| Research Abstract |
Although the etiology of intervertebral disc degeneration is poorly understood, one possible approach for the treatment includes regulation of cell cycle in nucleus pulposus cells. We investigated the cell cycle effects of nucleus pulposus cells in intervertebral disc degeneration. Our findings indicate that regulation of cell cycle in intervertebral disc cells is effective in preventing intervertebral disc degeneration.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population.2011
Author(s)
Takahashi Y, Matsumoto M, Karasugi T, Watanabe K, Chiba K, Kawakami N, Tsuji T, Uno K, Suzuki T, Ito M, Sudo H, et al.
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Journal Title
Journal of Orthopaedic Research. Epub ahead of print
Related Report
Peer Reviewed
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