Regulation of cell cycle in nucleus pulposus cells for the treatment of intervertebral disc degeneration

• Project/Area Number: 20591733
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Hokkaido University
• Principal Investigator: SUDO Hideki Hokkaido University, 大学院・医学研究科, 特任講師 (30374367)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 整形外科 / 脊椎外科 / 椎間板 / 細胞周期 / 再生医学

Research Abstract

Although the etiology of intervertebral disc degeneration is poorly understood, one possible approach for the treatment includes regulation of cell cycle in nucleus pulposus cells. We investigated the cell cycle effects of nucleus pulposus cells in intervertebral disc degeneration. Our findings indicate that regulation of cell cycle in intervertebral disc cells is effective in preventing intervertebral disc degeneration.

Research Products

• [Journal Article] Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration. (2011)
  • Author(s): 須藤英毅, et al.
  • Journal Title: Arthritis & Rheumatism. Epub ahead of print
  • Peer Reviewed
• [Journal Article] Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population. (2011)
  • Author(s): Takahashi Y, Matsumoto M, Karasugi T, Watanabe K, Chiba K, Kawakami N, Tsuji T, Uno K, Suzuki T, Ito M, Sudo H, et al.
  • Journal Title: Journal of Orthopaedic Research. Epub ahead of print
  • Peer Reviewed
• [Journal Article] Regulation of apoptosis in nucleus pulposus cells by optimized exogenous Bcl-2 overexpression. (2010)
  • Author(s): 須藤英毅, et al.
  • Journal Title: Journal of Orthopaedic Research. 28 Pages: 1608-13
  • Peer Reviewed
• [Journal Article] A wide spread echinococcosis of the spine. (2010)
  • Author(s): 須藤英毅, et al.
  • Journal Title: Journal of Neurology, Neurosurgery & Psychiatry. 81 Pages: 892-892
  • Peer Reviewed
• [Journal Article] One-stage posterior instrumentation surgery for the treatment of osteoporotic vertebral collapse with neurological deficits. (2010)
  • Author(s): 須藤英毅, et al.
  • Journal Title: European Spine Journal. 19 Pages: 907-15
  • Peer Reviewed
• [Journal Article] A late neurological complication following posterior correction surgery of severe cervical kyphosis. (2010)
  • Author(s): Hojo Y, Ito M, Abumi K, Kotani Y, Sudo H, et al
  • Journal Title: European Spine Journal. Epub ahead of print
  • Peer Reviewed
• [Journal Article] Simultaneous double-rod rotation technique in posterior instrumentation surgery for correction of adolescent idiopathic scoliosis. (2010)
  • Author(s): Ito M, Abumi K, Kotani Y, Takahata M, Sudo H
  • Journal Title: Journal of Neurosurgery Spine. 12 Pages: 293-300
  • Peer Reviewed
• [Journal Article] Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration. (2010)
  • Author(s): Sudo H, et al
  • Journal Title: Arthritis & Rheumatism Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Regulation of apoptosis in nucleus pulposus cells by optimized exogenous Bcl-2 overexpression. (2010)
  • Author(s): Sudo H, et al
  • Journal Title: Journal of Orthopaedic Research Volume: 28 Pages: 1608-1613
  • Peer Reviewed
• [Journal Article] A wide spread echinococcosis of the spine (2010)
  • Author(s): Sudo H, et al
  • Journal Title: Journal of Neurology, Neurosurgery & Psychiatry Volume: 81 Pages: 892-892
  • Peer Reviewed
• [Journal Article] One-stage posterior instrumentation surgery for the treatment of osteoporotic vertebral collapse with neurological deficits. (2010)
  • Author(s): Sudo H, et al
  • Journal Title: European Spine Journal Volume: 19 Pages: 907-915
  • Peer Reviewed
• [Journal Article] Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population. (2010)
  • Author(s): Takahashi Y, et al
  • Journal Title: Journal of Orthopaedic Research Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Replication study of the association between adolescent idiopathic scoliosis and two estrogen receptor genes. (2010)
  • Author(s): Takahashi Y, et al
  • Journal Title: Journal of Orthopaedic Research Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] A late neurological complication following posterior correction surgery of severe cervical kyphosis. (2010)
  • Author(s): Hojo Y, et al
  • Journal Title: European Spine Journal Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] One-stage posterior instrumentation surgery for the treatment of osteoporotic vertebral collapse with neurological deficits. (2010)
  • Author(s): Sudo H, et al
  • Journal Title: European Spine Journal (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] A wide spread echinococcosis of the spine (2010)
  • Author(s): Sudo H, et al
  • Journal Title: Journal of Neurology, Neurosurgery & Psychiatry (In press)
  • Peer Reviewed
• [Journal Article] Spinal cord compression by ligamentum flavum hematoma in the thoracic spine. (2009)
  • Author(s): 須藤英毅, et al.
  • Journal Title: Spine. 34
  • NAID: 120002646833
  • Peer Reviewed
• [Journal Article] Minimally invasive surgical treatment for tuberculous spondylodiscitis. (2009)
  • Author(s): Ito M, Sudo H, Abumi K, Kotani Y, Takahata M, Fujita M, Minami A.
  • Journal Title: Minim Invasive Neurosurg. 52 Pages: 250-3
  • Peer Reviewed
• [Journal Article] 血液透析に伴う高度脊柱変形に対する外科的治療 (2009)
  • Author(s): 須藤英毅, 他
  • Journal Title: 脊椎脊髄ジャーナル 22 Pages: 1042-48
• [Journal Article] 強直性脊椎炎による脊椎後弯症の手術治療 (2009)
  • Author(s): 須藤英毅, 他
  • Journal Title: 脊椎脊髄ジャーナル 22 Pages: 570-73
• [Journal Article] Spinal cord compression by ligamentum flavum hematoma in the thoracic spine. (2009)
  • Author(s): Sudo H, et al
  • Journal Title: Spine 34
  • NAID: 120002646833
  • Peer Reviewed
• [Journal Article] 環軸椎回旋位固定 (2008)
  • Author(s): 須藤英毅, 他
  • Journal Title: 脊椎脊髄ジャーナル 21 Pages: 1219-1222
• [Journal Article] リウマチ性環軸椎亜脱臼に対する環椎外側塊スクリューの治療成績 (2008)
  • Author(s): 須藤英毅, 他
  • Journal Title: 北海道整形災害外科学会誌 50 Pages: 88-91
  • Peer Reviewed
• [Journal Article] Minimally invasive surgical treatment for tuberculous spondylodiscitis
  • Author(s): Sudo H, et.al.
  • Journal Title: Minim invas neurosur (In press)
  • Peer Reviewed
• [Presentation] 化膿性脊椎椎間板炎の鏡視下掻爬洗浄 (2011)
  • Author(s): 須藤英毅, 他
  • Organizer: 第22回腰痛シンポジウム
  • Place of Presentation: 東京国際フォーラム,東京都
  • Year and Date: 2011-03-05
• [Presentation] 化膿性脊椎椎間板炎の鏡視下掻爬洗浄 (2011)
  • Author(s): 須藤英毅, 他
  • Organizer: 第22回腰痛シンポジウム
  • Place of Presentation: 東京国際フォーラム/東京都 招待講演
  • Year and Date: 2011-03-05
• [Presentation] Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration. (2011)
  • Author(s): 須藤英毅, et al.
  • Organizer: 2011 annual meeting of the American Academy of Orthopaedic Surgeons
  • Place of Presentation: San Diego Convention Center/ San Diego, CA, USA
• [Presentation] Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration. (2011)
  • Author(s): 須藤英毅, et al.
  • Organizer: 2011 annual meeting of the Orthopaedic Research Society.
  • Place of Presentation: Long Beach Convention Center/ Long Beach, CA, USA
• [Presentation] Regulation of apoptosis in nucleus pulposus cells by optimized exogenous Bcl-2 overexpression. (2011)
  • Author(s): 須藤英毅, et al.
  • Organizer: 2011 annual meeting of the Orthopaedic Research Society.
  • Place of Presentation: Long Beach Convention Center/ Long Beach, CA, USA
• [Presentation] Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration (2011)
  • Author(s): Sudo H, et al
  • Organizer: 2011 annual meeting of the Orthopaedic Research Society
  • Place of Presentation: Long Beach Convention Center/Long Beach, CA, USA
• [Presentation] Regulation of apoptosis in nucleus pulposus cells by optimized exogenous Bcl-2 overexpression. (2011)
  • Author(s): Sudo H, et al
  • Organizer: 2011 annual meeting of the Orthopaedic Research Society
  • Place of Presentation: Long Beach Convention Center/Long Beach, CA, USA
• [Presentation] Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration (2011)
  • Author(s): Sudo H, et al
  • Organizer: 2011 annual meeting of the American Academy of Orthopaedic Surgeons
  • Place of Presentation: San Diego Convention Center/San Diego, CA, USA
• [Presentation] 骨粗鬆症性椎体圧潰に対する手術療法-前方脊柱再建術と後方単独再建術の比較検討- (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第19回日本脊椎インストルメンテーション学会
  • Place of Presentation: 札幌プリンスホテル国際館パミール,札幌市
  • Year and Date: 2010-10-29
• [Presentation] 骨粗懇症性椎体骨折の最前線:骨粗繧症性椎体圧潰に対する手術療法-前方脊柱再建術と後方単独再建術の比較検討- (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第19回日本脊椎インストルメンテーション学会
  • Place of Presentation: 札幌プリンスホテル国際館パミール/札幌市
  • Year and Date: 2010-10-29
• [Presentation] Osteoporotic Spineの再建手術Vertebroplastyと後方再建手術の併用 (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第14回北大脊柱再建セミナー
  • Place of Presentation: 北大病院臨床大講堂,札幌市
  • Year and Date: 2010-07-23
• [Presentation] 環軸椎固定:環椎外側塊スクリュー (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第14回北大脊柱再建セミナー
  • Place of Presentation: 北大病院臨床大講堂,札幌市
  • Year and Date: 2010-07-23
• [Presentation] 脊柱変形矯正の実際 胸椎・胸腰椎移行部の除圧と後弯矯正 (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第14回北大脊柱再建セミナー
  • Place of Presentation: 北大病院臨床大講堂,札幌市
  • Year and Date: 2010-07-23
• [Presentation] Osteoporotic Spineの再建手術Vertebroplastyと後方再建手術の併用 (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第14回北大脊柱再建セミナー
  • Place of Presentation: 北大臨床大講堂/札幌市 招待講演
  • Year and Date: 2010-07-23
• [Presentation] 環軸椎固定:環椎外側塊スクリュー (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第14回北大脊柱再建セミナー
  • Place of Presentation: 北大臨床大講堂/札幌市 招待講演
  • Year and Date: 2010-07-23
• [Presentation] 脊柱変形矯正の実際胸椎・胸腰椎移行部の除圧と後弯矯正 (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第14回北大脊柱再建セミナー
  • Place of Presentation: 北大臨床大講堂1札幌市 招待講演
  • Year and Date: 2010-07-23
• [Presentation] Caspase 3をターゲットとした椎間板組織に対する変性抑制効果 (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第119回北海道整形災害外科学会
  • Place of Presentation: 北大学術交流会館,札幌市
  • Year and Date: 2010-06-26
• [Presentation] 骨粗鬆症性椎体骨折の最前線:骨粗鬆症性椎体圧潰に対する手術療法-前方脊柱再建術と後方単独再建術の比較検討- (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第119回北海道整形災害外科学会
  • Place of Presentation: 北大学術交流会館,札幌市
  • Year and Date: 2010-06-26
• [Presentation] Caspase 3をターゲットとした椎間板組織に対する変性抑制効果 (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第119回北海道整形災害外科学会
  • Place of Presentation: 北大学術交流会館/札幌市
  • Year and Date: 2010-06-26
• [Presentation] 骨粗繧症性椎体骨折の最前線:骨粗繧症性椎体圧潰に対する手術療法-前方脊柱再建術と後方単独再建術の比較検討- (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第119回北海道整形災害外科学会
  • Place of Presentation: 北大学術交流会館/札幌市
  • Year and Date: 2010-06-26
• [Presentation] 骨粗鬆症性椎体圧潰に対する手術療法-前方脊柱再建術と後方単独再建術の比較検討- (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第83回日本整形外科学会学術総会
  • Place of Presentation: 東京国際フォーラム,東京都
  • Year and Date: 2010-05-29
• [Presentation] 骨粗霧症性椎体圧潰に対する手術療法-前方脊柱再建術と後方単独再建術の比較検討- (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第83回日本整形外科学会学術総会
  • Place of Presentation: 東京国際フォーラム/東京都
  • Year and Date: 2010-05-29
• [Presentation] 神経障害を伴う骨粗鬆症性椎体圧潰に対する後方単独脊柱再建術の術後成績 (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第39回日本脊椎脊髄病学会
  • Place of Presentation: 新阪急ホテル,高知市
  • Year and Date: 2010-04-23
• [Presentation] 神経障害を伴う骨粗霧症性椎体圧潰に対する後方単独脊柱再建術の術後成績 (2010)
  • Author(s): 須藤英毅, 他
  • Organizer: 第39回日本脊椎脊髄病学会
  • Place of Presentation: 高知新阪急ホテル/高知市
  • Year and Date: 2010-04-23
• [Presentation] 神経障害を伴う骨粗鬆症性椎体圧潰に対する後方単独脊柱再建術 (2009)
  • Author(s): 須藤英毅, 他
  • Organizer: 第117回北海道整形災害外科学会
  • Place of Presentation: 小樽
  • Year and Date: 2009-06-27
• [Presentation] アポトーシス関連遺伝子を用いた椎間板細胞の老化変性の制御機構 (2009)
  • Author(s): 須藤英毅, 他
  • Organizer: 第117回北海道整形災害外科学会
  • Place of Presentation: 小樽
  • Year and Date: 2009-06-27
• [Presentation] 骨粗鬆症性椎体圧潰に対する超高分子量ポリエチレンケーブルを併用した後方単独再建術の中期術後成績 (2009)
  • Author(s): 須藤英毅, 他
  • Organizer: 第82回日本整形外科学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-15
• [Presentation] アポトーシス関連遺伝子を用いた椎間板細胞の老化変性の制御機構 (2009)
  • Author(s): 須藤英毅, 他
  • Organizer: 第38回日本脊椎脊髄病学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-04-23
• [Presentation] 骨粗鬆症性椎体圧潰に対する超高分子量ポリエチレンケーブルを併用した後方単独再建術の中期術後成績 (2009)
  • Author(s): 須藤英毅, 他
  • Organizer: 第82回日本整形外科学会学術総会
  • Place of Presentation: 福岡サンパレルホテル,福岡市
• [Presentation] 神経障害を伴う骨粗鬆症性椎体圧潰に対する後方単独脊柱再建術 (2009)
  • Author(s): 須藤英毅, 他
  • Organizer: 第117回北海道整形災害外科学会
  • Place of Presentation: グランドパーク小樽,小樽市
• [Presentation] アポトーシス関連遺伝子を用いた椎間板細胞の変性制御機構 (2009)
  • Author(s): 須藤英毅, 他
  • Organizer: 第117回北海道整形災害外科学会
  • Place of Presentation: グランドパーク小樽,小樽市
• [Presentation] アポトーシス関連遺伝子を用いた椎間板細胞の変性制御機構 (2009)
  • Author(s): 須藤英毅, 他
  • Organizer: 第38回日本脊椎脊髄病学会
  • Place of Presentation: 神戸ポートピアホテル,神戸市
• [Presentation] 環椎外側塊スクリューによる上位頚椎再建術の中・長期成績 (2008)
  • Author(s): 須藤英毅, 他
  • Organizer: 第81回日本整形外科学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2008-05-23
• [Presentation] 環椎外側塊スクリューによる上位頚椎再建術の中・長期成績 (2008)
  • Author(s): 須藤英毅, 他
  • Organizer: 第81回日本整形外科学会学術総会
  • Place of Presentation: 札幌プリンスホテル国際館パミール,札幌市
• [Remarks] ホームページ等
  • URL: http://www.hokudai.ac.jp/bureau/topics/press_release/110131_pr_med.pdf
• [Remarks]
  • URL: http://www.hokudai.ac.jp/bureau/topics/press_release/110131_pr_med.pdf