Clinical application of artificial intervertebral disc and development of novel hybrid type regenerative disc

• Project/Area Number: 20591734
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Hokkaido University
• Principal Investigator: KOTANI Yoshihisa Hokkaido University, 病院, 講師 (40312368)
• Co-Investigator(Kenkyū-buntansha): ABUMI Kuniyosi 北海道大学, 大学院・医学研究科, 教授 (00159419) ; MINAMI Akio 北海道大学, 大学院・医学研究科, 教授 (20133738)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 脊椎脊髄病学 / 生体材料 / 椎間板 / 再生医学 / 人工椎間板 / 臨床治験 / 間葉系幹細胞 / 培養髄核細胞 / 三次元立体織物

Research Abstract

For clinical application of artificial disc, we received the starting approval from PMDA and continued the negotiation with US company. For the regenerative disc research, we selected mesenchymal stem cell or cultured nucleus cell for regenerative cells. The bioabsorbable microfiber was fabricated into the three-dimensional configuration for three-dimensional scaffold.

Research Products

• [Journal Article] A bimimetic artificial intervertebral disc system composed of a cubic three-dimensional fabric. (2010)
  • Author(s): Shikinami Y, Kawabe Y, Yasukawa K, Tsuta K, Kotani Y, Abumi K
  • Journal Title: The Spine Journal 10 Pages: 142-52
  • Peer Reviewed
• [Journal Article] A late neurological complication followig posterior correction surgery of severe cervical kyphosis. (2010)
  • Author(s): Hojo Y, Ito M, Abumi K, Kotani Y, Sudo H, Takahata M, Minami A
  • Journal Title: Eur Spine J Epub ahead of print
  • Peer Reviewed
• [Journal Article] Neurological recovery after surgical treatment of giant cervical pseudomeningoceles extending to lumbar spine associated with previous brachial plexus injury. (2010)
  • Author(s): Kotani Y, Abumi K, Ito M, Terae S, Hisada Y, Minami A
  • Journal Title: Eur Spine J
  • Peer Reviewed
• [Journal Article] Simultaneous double-rod rotation technique in posterior instrumentation surgery for correction of adlescent idiopathic scoliosis. (2010)
  • Author(s): Ito M, Abumi K, Kotani Y, Takahata M, Sudo H, Hojo Y, Minami A
  • Journal Title: J Neurosurg Spine 12 Pages: 293-300
  • Peer Reviewed
• [Journal Article] One-stage posterior instrumentation surgery for the treatment of osteoporotic vertebral collapse with neuurological defects. (2010)
  • Author(s): Sudo H, Ito M, Abumi K, Kotani Y, Takahata M, Hojo Y, Minami A
  • Journal Title: Eur Spine J 19 Pages: 907-15
  • Peer Reviewed
• [Journal Article] 脊椎脊髄外科におけるMotion Preservation Technology:脊椎可動性温存技術の現状と本邦発の人工椎間板臨床応用への取り組み (2010)
  • Author(s): 小谷善久、鐙邦芳、伊東学、三浪明男
  • Journal Title: Journal of Spine Research 1 Pages: 8-16
  • NAID: 10027713633
  • Peer Reviewed
• [Journal Article] Neurological recovery after surgical treatment of giant cervical pseudom eningocele extending to lumar spine associated with previous brachial plexus injury (2010)
  • Author(s): Kotani Y, et al.
  • Journal Title: Eur Spine J Volume: 19S2
  • Peer Reviewed
• [Journal Article] 外傷性頸部症候群に伴う肩甲帯部痛 (2010)
  • Author(s): 小谷善久
  • Journal Title: MB Orthop Volume: 23 Pages: 61-66
• [Journal Article] A biomimetic artificial intervertebral disc system composed of a cubic three-dimensional fabric. (2010)
  • Author(s): Shikinami Y, Kotani Y, et al.
  • Journal Title: Spine J Volume: 10 Pages: 141-152
  • Peer Reviewed
• [Journal Article] A bimimetic artificial intervertebral disc system composed of a cubic three-dimensional fabric. (2010)
  • Author(s): Shikinamiy, Koani Y
  • Journal Title: The Spine Journal Online
  • Peer Reviewed
• [Journal Article] Neurological recovery after surgical treatment of giant cervical pseudo meningoceles extending to lumbar spine associated with previous brachial plexus injury (2010)
  • Author(s): Kotani Y, et al.
  • Journal Title: Eur Spine J Online
  • Peer Reviewed
• [Journal Article] 脊椎脊髄外科におけるMotion Preservation Technology:脊椎可動性温存技術の現状と本邦発の人工椎間板臨床応用への取り組み (2010)
  • Author(s): 小谷善久, 鐙邦芳, 三浪明男
  • Journal Title: Journal of Spine Research 1 Pages: 8-16
  • NAID: 10027713633
  • Peer Reviewed
• [Journal Article] Spinal cord compression by ligamentum flavum hematoma in the thoracic spine. (2009)
  • Author(s): Sudo H, Abumi K, Ito M., Kotani Y, Takahata M, Minami A
  • Journal Title: Spine 34
  • NAID: 120002646833
  • Peer Reviewed
• [Journal Article] Minimmaly invasive surgical treatment for tuberculous spondylodiscitis. (2009)
  • Author(s): Ito M, Sudo H, Abumi K, Kotani Y, Takahata M, Fujita M, Minami A
  • Journal Title: Minim Invas Neurosurg 52 Pages: 1-4
  • Peer Reviewed
• [Journal Article] Minimum two-year outcome of cervical laminoplasty with deep extensor muscle preserving approach : Impact on cervical spine function and quality of life. (2009)
  • Author(s): Kotani Y, Abumi K, Ito M, Sudo H, Takahata M, Ohshima S, Hojo Y, Minami A
  • Journal Title: Eur Spine J 18 Pages: 663-71
  • Peer Reviewed
• [Journal Article] Neurological recovery from pentaplegia after surgical treatment of sacral plasmacytoma presenting POEMS syndrome. Case report. (2009)
  • Author(s): Kotani Y, Ito M, Abumi K, Yasui K, Minami A
  • Journal Title: J Neurosurg Spine 10 Pages: 324-28
  • Peer Reviewed
• [Journal Article] 脊椎脊髄外科におけるMotion Preservation Technology(総説) (2009)
  • Author(s): 小谷善久、鐙邦芳、三浪明男
  • Journal Title: 日本腰痛学会雑誌 15(日本腰痛学会優秀論文賞受賞) Pages: 86-94
  • Peer Reviewed
• [Journal Article] 脊椎脊髄外科におけるMotion Preservation Technology(総説) (2009)
  • Author(s): 小谷善久, 鐙邦芳, 三浪明男
  • Journal Title: 日本腰痛学会雑誌 15 Pages: 86-94
  • Peer Reviewed
• [Journal Article] Minimum two-year outcome of cervical laminoplasty with deep extensor muscle preserving approach : Impact on cervical spine function and quality of life (2009)
  • Author(s): Kotani Y, et.al.
  • Journal Title: Eur Spine Journal E-pub
  • Peer Reviewed
• [Journal Article] Neurological recovery from pentaplegia after surgical treatment of sacr al plasmacytoma presenting POEMS syndrome. Case report (2009)
  • Author(s): Kotani Y, et.al.
  • Journal Title: J Neurosurg (Spine) (In press)
  • Peer Reviewed
• [Journal Article] 外傷性頚部症候群のトリートメント・ストラテジー (2009)
  • Author(s): 小谷善久
  • Journal Title: MB Ortkop 22 Pages: 21-25
• [Journal Article] 外傷性頚部症候群の病態解析に関するmultidisciplinary approach (2009)
  • Author(s): 小谷善久
  • Journal Title: 整形災害外科 52 Pages: 139-143
• [Journal Article] Clinical results and complications of circumferential spinal cord decompression through a single posterior approach for thoracic myelopathy caused by ossification of posterior longitudinal ligament. (2008)
  • Author(s): Takahata M, Ito M, Abumi K, Kotani Y, Sudo H, Minami A
  • Journal Title: Spine. 33 Pages: 1199-208
  • NAID: 10027233598
  • Peer Reviewed
• [Presentation] 脊椎人工椎間板に関する産学共同研究の現況と諸問題 (2010)
  • Author(s): 小谷善久, 他
  • Organizer: 日本整形外科学会基礎学術集会
  • Place of Presentation: 京都市 招待講演
• [Presentation] Development and clinical application of biomimetic artificial interverte bral disc with the unique structure of three-dimensional fabric. (2009)
  • Author(s): 小谷善久、鐙邦芳、三浪明男
  • Organizer: 第13回脊椎と神経を語る会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-03-14
• [Presentation] 脊椎脊髄外科におけるバイオメカニクスと最近の知見 (2009)
  • Author(s): 小谷善久
  • Organizer: 第4回大阪バイオメカニクス研究会
  • Place of Presentation: 大阪市
  • Year and Date: 2009-03-07
• [Presentation] Comparative analysis of minimally invasive posterolateral fusion with transcutaneous pedicle screw instrumentation versus conventional approach for degenerative spondylolisthesis (2009)
  • Author(s): Kotani Y, et al
  • Organizer: International meeting on advanced spine techniques(IMAST), 16^<th> annual meeting
  • Place of Presentation: Vienna, Austria
• [Presentation] Comparative analysis of minimally invasive posterolateral fusion with transcutaneous pedicle screw instrumentation versus conventional approach for degenerative spondylolisthesis (2009)
  • Author(s): Kotani Y, et al.
  • Organizer: Scoliosis Research Society, 44^<th> annual meeting
  • Place of Presentation: San Antonio, Texas USA
• [Presentation] 脊椎脊髄外科におけるMotion Preservation Technology (2008)
  • Author(s): 小谷善久
  • Organizer: 第16回日本腰痛学会
  • Place of Presentation: 東京(日本腰痛学会優秀論文賞受賞)
  • Year and Date: 2008-11-01
• [Presentation] 脊椎脊髄外科におけるMotion Preservation Technology (2008)
  • Author(s): 小谷善久, 他
  • Organizer: 第16回日本腰痛学会
  • Place of Presentation: シェーンバッハ・サボー
  • Year and Date: 2008-01-01
• [Book] the Cranivertebral junction(Goel A, Cassiola F, ed.)(Occipitocervical stabilization.) (2011)
  • Author(s): Abumi K, Ito M, Kotani Y
  • Publisher: Thieme-Stuttgart
• [Book] 2010 American Academy of Orthopaedic Surgeons(Cervical pedicle screw fixation. Chapter 21) (2010)
  • Author(s): Abumi K, Ito M, Kotani Y
• [Book] The Craniovertebral Junction (2010)
  • Author(s): Abumi K, Kotani Y
  • Total Pages: 15
  • Publisher: Thieme-Stuttgart, New York
• [Book] Cervical Pedicle Screw Fixation (2010)
  • Author(s): Abumi K, Kotani Y
  • Total Pages: 8
  • Publisher: American Academy of Orthopaedic Surgeons
• [Book] Cervical Spine Truma(Vaccaro A and Andersson P, ed.)(Subaxial injuries : Pillar (Pedicle and lateral mass) fractures.) (2009)
  • Author(s): Abumi K, Kotani Y, Ito M, Vaccaro A
  • Publisher: Rothman institute