Elucidation of the molecular pathogenesis of calcification of the ligament
| Project/Area Number |
20591739
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AE Keisuke Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (20376726)
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| Co-Investigator(Renkei-kenkyūsha) |
SHINOMIYA Ken-ichi 東京医科歯科大学, 医歯学総合研究科, 教授 (20111594)
ASOU Yoshinori 東京医科歯科大学, 医学部附属病院, 助教 (50345279)
TAKEDA Shu 慶應義塾大学, 医学部, 准教授 (30376727)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脊椎脊髄病学 / 靭帯骨化症 / Runx3 / 骨代謝 / Runx遺伝子 |
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| Research Abstract |
We uncovered that Runx3 regulates osteoblast proliferation by means of Runx3-deficeint mice. We also studied the role of Runx3 in caicification of the ligament and observed that Runx3 done not play a major role in OPLL though the use of mouse model of OPLL.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Runx1 and Runx2 cooperate during sternum morphogenesis.2010
Author(s)
Kimura A, Inose H, Yano F, Fujita F, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung U, Martin JF, Iseki S, Shinomiya K, Takeda S.
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Journal Title
Development 137
Pages: 1159-1167
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[Journal Article] Clear cell sarcoma of soft tissue : a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases2008
Author(s)
Hisaoka M, Ishida T, Kuo TT, Matsuyama A, Imamura T, Nishida K, Kuroda H, Inayama Y, Oshiro H, Kobayashi H, Nakajima T, Fukuda T, Ae K, Hashimoto H.
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Journal Title
American Journal of Surgical Pathology. 32(3)
Pages: 452-60
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