Storage and allogeneric transplantation of peripheral nerve using a green tea polyphenol solution in a canine model

• Project/Area Number: 20591742
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto University
• Principal Investigator: KAKINOKI Ryosuke Kyoto University, 医学研究科, 准教授 (20314198)
• Co-Investigator(Renkei-kenkyūsha): IKEGUCHI Ryosuke 京都大学, 医学研究科, 助教 (80437201) ; NAKAMURA Takashi 京都大学, 医学研究科, 教授 (10201675)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ポリフェノール / 末梢神経保存 / 同種神経移植 / 神経再生 / 移植免疫

Research Abstract

Successful nerve regeneration was observed in the polyphenol-treated nerve allografts when transplanted in association with a therapeutic dose of FK506. The total myelinated axon numbers and amplitudes of the muscle action potentials correlated significantly with the blood FK506 concentration. The data indicate that polyphenols can protect nerve tissue from ischemic damage for one month; however, the effects of immune suppression seem insufficient to permit allogeneic transplantation of peripheral nerves in a canine model.

Research Products

• [Journal Article] Storage and allogeneic transplantation of peripheral nerve using a green tea polyphenol solution in a canine model. (2011)
  • Author(s): Nakayama K, Kakinoki R, Ikeguchi R, Yamakawa T, Matsumoto T, Ohta S, Fujita S, Hyon SH, Nakamura T
  • Journal Title: J Brachial Plexus and Peripheral Nerve Injury Volume: 28(5) Pages: 17-25
  • Peer Reviewed
• [Journal Article] Storage and allogeneric transplantation of peripheral nerve using a green tea polyphenol solution in a canine model. (2010)
  • Author(s): Nakayama K, Kakinoki R, Ikeguchi R, Yamakawa T, Matsumoto T, Ohta S, Fujita S, Hyon SH, Nakamura T.
  • Journal Title: J Brachial Plex Peripher Nerve Inj. 28 Pages: 17-25
  • Peer Reviewed
• [Presentation] ポリフェノールを用いた末梢神経保存と同種移植に関する研究 (2010)
  • Author(s): 柿木良介、中村孝志、池口良輔, 他
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2010-10-15
• [Presentation] ポリフェノールを用いた末梢神経保存 (2010)
  • Author(s): 柿木良介
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-10-15