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Pinealectomy causes high turn-over osteoporosis and impairs endochondral ossification in chicken vertebrae

Research Project

Project/Area Number 20591748
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionTokyo Medical University

Principal Investigator

MIYAKI Takayoshi (2010)  Tokyo Medical University, 医学部, 准教授 (20157598)

宮木 孝昌 (2008-2009)  Tokyo Medical University, 医学部, 准教授 (60366094)

Co-Investigator(Kenkyū-buntansha) TERAYAMA Hayato  東京医科大学, 医学部, 助教 (00384983)
ITOH Masahiro  東京医科大学, 医学部, 教授 (00232471)
NAITO Munekazu  東京医科大学, 医学部, 講師 (10384984)
HIRAI Shuichi  東京医科大学, 医学部, 助教 (70516054)
AOTA Yoichi  横浜市立大学, 医学部, 准教授 (40363824)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords脊椎脊髄病学(側彎症・整形外科・解剖学・組織学・内分泌) / 側彎 / 骨成長 / 動物モデル / 脊柱変性 / 骨成長速度 / 松果体 / 脊椎 / 側彎症 / カルセイン / ヒヨコ / メラトニン / テトラサイクリン
Research Abstract

Despite many studies over several decades, the etiology and pathogenesis of idiopathic scoliosis are not known. Melatonin, hormone produced by pineal gland, has been suggested to play an important role in scoliosis and osteoporosis development. In the present study, growth modulation and osteoporosis were analysed in mid-sagittal sections of T7 vertebral bodies in pinealectomy chicken model. Histomorphometric study was performed before the development of marked scoliosis (6 days after pinealectomy). All chickens were double labeled with Calcein injected at 2 and 4 days prior to sacrifice. In pinealectomy chickens, histologies detected a generalized osteopenia. This decrease in trabecular bone was particularly noticeable at the mid-portion of the vertebrae, where pinealectomy chickens had an approximately 50% lower BV/TV than control chickens (14.2±1.8 % versus 7.3±0.8 %; mean±s.d., n=5), which is highly significant (p<0.00005). Histomorphometric study revealed that pinealectomy induced high-turnover osteoporosis. Pinealectomy also resulted in substantial changes in endochondral ossification. In general, avian chondro-osseous junction undulates because metaphyseal vessels invade the growth plate at intervals, and growth plate cartilage becomes included within the newly formed bone. In normal chickens, about 9% of the chondro-osseous junction was covered by osteoblasts (Ob.S/BS). The coverage was significantly increased in pinealectomized chickens (9.1±4.3 % versus 38.9±11.1 %; p<0.05). Longitudinal growth rate, calculated based on unlabeled width in hypertrophic zone was significantly reduced (98.9±32.4 μm/day versus 45.8±5.5 μm/day, p<0.05). Previous in vitro study illustrated that melatonin inhibited the activity of both osteoblast and osteoclast in the co-culture of both cell types. This is the first report illustrating ongoing histological changes of impaired endochondral ossification in MLT deficiency.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (67 results)

All 2010 2009 2008 Other

All Journal Article (43 results) (of which Peer Reviewed: 43 results) Presentation (23 results) Remarks (1 results)

  • [Journal Article] 星状神経節の位置と膜構造についての解剖学的研究2010

    • Author(s)
      北山稔恭,齋藤敏之,岩渕知恵,宮木孝昌,Hanno Steinek,伊藤正裕,大井良之
    • Journal Title

      日本歯科麻酔学会雑誌 38(2)

      Pages: 169-175

    • NAID

      10026405004

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 転移性脊椎腫瘍患者における生命および機能予後を予測するスコアリングシステムと治療戦略アルゴリズムの構築2010

    • Author(s)
      青田洋一、斉藤知行、山下孝之、市川靖史、比留間徹、小川賢一
    • Journal Title

      日本ホスピス・緩和ケア研究振興財団調査研究報告書 第9号

      Pages: 1-11

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 棘突起縦割片側進入による頚椎undercuttinglaminectomyの臨床成績2010

    • Author(s)
      河井卓也、青田洋一、中村直行、小林洋介、若山悠介、斉藤知行
    • Journal Title

      Journal of Spine Research 1

      Pages: 1497-1501

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of autoantigens relevant to localized autoimmunity in murine testis and epididymis.2010

    • Author(s)
      Ning Qu, Naito M, Terayama H, Hirai S, Li J, Ogawa Y, Kitaoka M, Itoh M
    • Journal Title

      Journal of Reproductive Immunology. 87

      Pages: 45-51

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Difference in abundance of blood and lymphatic capillaries in the murine epididymis.2010

    • Author(s)
      Hirai S, Naito M, Terayama H, Qu N, Miura M, Shirakami G, Itoh M
    • Journal Title

      Medical Molecular Morphology 43(1)

      Pages: 37-42

    • NAID

      10026443189

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Late onset of thoracic myelopathy with Type 2 congenital deformity : A case report.2010

    • Author(s)
      Ishida K, Aota Y, Uesugi M, Shinoda K, Mizuma K, Saito T
    • Journal Title

      The Open Spine Journal 2

      Pages: 21-2

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 単孔類カモノハシとハリモグラの肝臓の血管系2010

    • Author(s)
      宮木孝昌、伊藤正裕、小泉政啓、山崎正博
    • Journal Title

      形態科学

      Volume: 13(2) Pages: 37-40

    • NAID

      40017244763

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 鳥類の肝臓の門脈分布2010

    • Author(s)
      宮木孝昌・伊藤正裕
    • Journal Title

      形態科学

      Volume: 14(1) Pages: 15-23

    • NAID

      40018716432

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Difference in abundance of blood and lymphatic capillaries in the murine epididymis.2010

    • Author(s)
      Hirai S, Naito M, Terayama H, Itoh M, et al
    • Journal Title

      Med Mol Morphol

      Volume: 43(1) Pages: 37-42

    • NAID

      10026443189

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal arm position for evaluation of spinal sagittal balance2010

    • Author(s)
      Aota Y, Saito T, Kuniya H, et al
    • Journal Title

      Journal of Spinal Disorders and Techniques

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 後頭骨螺子固定システムを用いた後頭頚・胸椎固定術の手術成績2009

    • Author(s)
      中村潤一郎、山田勝崇、三ツ木直人、石田航、上杉昌章、青田洋一、斉藤知行
    • Journal Title

      臨整外 44

      Pages: 93-97

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腰部脊柱管狭窄症の実態調査と神奈川版LCS診断ツールの開発(第一報)2009

    • Author(s)
      青田洋一、持田讓治、小森博達、出沢明
    • Journal Title

      東日本整災会誌 21

      Pages: 171-179

    • NAID

      10025103679

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 最近の脊椎カリエスにおけるDoctor's delayの検討2009

    • Author(s)
      高倫浩、青田洋一、上杉昌章、加藤慎也、國谷洋、齋藤和行
    • Journal Title

      日本腰痛会誌 15(1)

      Pages: 173-179

    • NAID

      130000152047

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 神経根型腰部脊柱管狭窄症におけるMRミエログラフィーによる神経根圧迫形態の評価2009

    • Author(s)
      加藤慎也、青田洋一、上杉昌章、國谷洋、高倫浩、齋藤和行
    • Journal Title

      日本腰痛会誌 15(1)

      Pages: 117-121

    • NAID

      130000152039

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 長時間着座姿勢における連動型腰椎用CPMの腰痛予防効果の根拠2009

    • Author(s)
      青田洋一、上杉昌章、加藤慎也、國谷洋、高倫浩、齋藤和行
    • Journal Title

      日本腰痛会誌 15(1)

      Pages: 122-131

    • NAID

      130000152040

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The pattern of the arterial supply of the pancreas in anthropoid apes, catarrhine monkeys and platyrrhine monkeys.2009

    • Author(s)
      Shawuti A, Miyaki T, Saito T, Itoh M
    • Journal Title

      Okajimas Folia Anat Jpn. 6(3)

      Pages: 79-88

    • NAID

      130004495066

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anatomy of the human thoracolumbar Rami dorsales nervi spinalis.2009

    • Author(s)
      Steinke H, Saito T, Miyaki T, Oi Y, Itoh M, Spanel-Borowski K
    • Journal Title

      Annal Anat 191

      Pages: 408-416

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histopathology and delayed-type hypersensitivity of C3H/He and A/J mice after unilateral testicular rupture.2009

    • Author(s)
      Naito M, Sakamoto Y, Terayama H, Hirai S ,Ning Qu, Aota Y, Itoh M
    • Journal Title

      Journal of Reproductive Immunology

      Pages: 55-61

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Does the fists-on-clavicles position represent a functional standing position?2009

    • Author(s)
      Aota Y, Saito T, Uesugi M, Ishida K, Shinoda K, Mizuma K
    • Journal Title

      Spine (Phila Pa 1976) 15 34(8)

      Pages: 808-12

    • NAID

      10027240775

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A predictive factor for acquiring an ideal lower limb realignment after opening-wedge high tibial osteotomy.2009

    • Author(s)
      Bito H, Takeuchi R, Kumagai K, Aratake M, Saito I, Hayashi R, Sasaki Y, Aota Y, Saito T
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc 17(4)

      Pages: 382-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical results and radiographical evaluation of opening wedge high tibial osteotomy for spontaneous osteonecrosis of the knee.2009

    • Author(s)
      Takeuchi R, Aratake M, Bito H, Saito I, Kumagai K, Hayashi R, Sasaki Y, Akamatsu Y, Ishikawa H, Amakado E, Aota Y, Saito T
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc 17(4)

      Pages: 361-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Does the "fists-on-clavicles" position represent a functional standing position?2009

    • Author(s)
      Aota Y, Saito T, Uesugi M, Ishida K, Shinoda K, Mizuma K
    • Journal Title

      Spine 34

      Pages: 808-812

    • NAID

      10027240775

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anatomy of the human thoracolumbar Rami dorsales nervi spinalis.2009

    • Author(s)
      Steinke H, Saito T, Miyaki T, Oi Y, Itoh M, Spanel-Borowski K
    • Journal Title

      Ann Anat 191

      Pages: 408-416

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経根型腰部脊柱管狭窄症におけるMRミエログラフィーによる神経根圧迫形態の評価2009

    • Author(s)
      加藤慎也、青田洋一、上杉昌章、國谷洋、高倫浩、齋藤和行
    • Journal Title

      日本腰痛会誌 15

      Pages: 117-121

    • NAID

      130000152039

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The pattern of the arterial supply of the pancreas in anthropoid apes, catarrhine monkeys and platyrrhine monkeys.2009

    • Author(s)
      Shawuti A, Miyaki T, Saito T, Itoh M
    • Journal Title

      Okajimas Folia Anat Jpn 86

      Pages: 79-88

    • NAID

      130004495066

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 長時間着座姿勢における連動型腰椎用CPMの腰痛予防効果の根拠2009

    • Author(s)
      青田洋一、上杉昌章、加藤慎也、國谷洋、高倫浩、齋藤和行
    • Journal Title

      日本腰痛会誌 15

      Pages: 122-131

    • NAID

      130000152040

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histopathology of the tubuli recti at the start of experimentalautoimmune orchitis in mice.2009

    • Author(s)
      Naito M, Terayama H, Hirai S, Qu N, Kawata S, Itoh M
    • Journal Title

      Medical Molecular Morphology 42

      Pages: 230-235

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] スンクスの膵臓と膵管分布2008

    • Author(s)
      宮木孝昌,仲間一雅,アリムジャン,伊藤正裕
    • Journal Title

      形態科学 12(1)

      Pages: 23-26

    • NAID

      40016423140

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 狭鼻猿三種の膵臓の動脈分布2008

    • Author(s)
      アリムジャン,宮木孝昌,齋藤敏之,伊藤正裕
    • Journal Title

      形態科学 12(1)

      Pages: 27-31

    • NAID

      40016423141

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 広鼻猿リスザルの膵臓の動脈分布2008

    • Author(s)
      アリムジャン,宮木孝昌,斎藤敏之,伊藤正裕
    • Journal Title

      形態科学 12(1)

      Pages: 33-35

    • NAID

      40016423142

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腰部脊柱管狭窄症に対する棘突起片側切離進入法を用いた片側進入両側除圧術の治療成績の両側進入との比較2008

    • Author(s)
      上杉昌章、青田洋一、石田航、篠田圭介、水摩晃一、斉藤知行
    • Journal Title

      東日本整災会誌 20

      Pages: 612-615

    • NAID

      10024779853

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lightweight Plastination2008

    • Author(s)
      Steinke H, Rabi S, Saito T, Sawuti A, Miyaki T, Itoh M
    • Journal Title

      Annal Anat 190

      Pages: 428-431

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The presence of intra-tubular lymphocytes in normal testis of the mouse2008

    • Author(s)
      Naito M, Terayama H, Hirai S, Ning Qu, Moriyama H, Itoh M
    • Journal Title

      Okajimas Folia Anatomica Japonica 85(3)

      Pages: 91-96

    • NAID

      130004495055

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Right gonadal arteries passing dorsally to the inferior vena cava : embryological hypotheses.2008

    • Author(s)
      Terayama H, Shuang-Qin Yi, Naito M, Ning Qu, Hirai S, Kitaoka M, Iimura A, Moriyama H, Steinke H, Itoh M
    • Journal Title

      Surgical and Radiologic Anatomy 30(8)

      Pages: 657-61

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Splenic cytokines in mice immunized with testicular germ cells2008

    • Author(s)
      Tokunaga Y, Terayama H, Naito M, Ning Qu, Hirai S, Ogawa Y, Shuang-Qin Yi, Itoh M
    • Journal Title

      International Journal of Andrology 31(5)

      Pages: 471-476

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A study of the accessory hepatic vein to segments VI and VII with a morphological reconsideration of the human liver.2008

    • Author(s)
      Buhe S, Miyaki T, Saito T, Sawuti A, Terayama H, Naito M, Yi SQ, Itoh M
    • Journal Title

      Surg Radiol Anat. 30(3)

      Pages: 201-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure of thymic cysts in congenital lymph nodes lacked mice2008

    • Author(s)
      Nakamura Y, Ning Qu, Terayama H, Naito M, Shuang-Qin Yi, Moriyama H, Itoh M
    • Journal Title

      Anatomia Histologia Embryologia 37

      Pages: 126-130

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in physical function after palliative surgery for metastatic spinal tumor : association of the revised Tokuhashi score with neurologic recovery.2008

    • Author(s)
      Yamashita T, Aota Y, Kushida K, Murayama H, Hiruma T, Takeyama M, Iwamura Y, Saito T
    • Journal Title

      Spine (Phila Pa 1976) 33(21)

      Pages: 2341-6

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical results of intrapedicular partial pediculectomy for lumbar foraminal stenosis.2008

    • Author(s)
      Ozeki N, Aota Y, Uesugi M, Kaneko K, Mihara H, Niimura T, Saito T
    • Journal Title

      J Spinal Disord Tech 21(5)

      Pages: 324-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The correlation of diffusion-weighted magnetic resonance imaging in cervical compression myelopathy with neurologic and radiologic severity.2008

    • Author(s)
      Aota Y, Niwa T, Uesugi M, Yamashita T, Inoue T, Saito T
    • Journal Title

      Spine (Phila Pa 1976) 33(7)

      Pages: 814-20

    • NAID

      10027232246

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] スンクスの膵臓と膵管分布2008

    • Author(s)
      宮木孝昌
    • Journal Title

      形態科学 12 (1)

      Pages: 23-26

    • NAID

      40016423140

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 狭鼻猿三種の膵臓の動脈分布2008

    • Author(s)
      阿刀木江沙吾提
    • Journal Title

      形態科学 12 (1)

      Pages: 27-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The correlation of diffusion-weighted magnetic resonance imaging in cervical compression myelopathy with neurological and radiological severity2008

    • Author(s)
      Aota Y
    • Journal Title

      Spine 33

      Pages: 814-820

    • NAID

      10027232246

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 圧迫性頸髄症手術例における拡散強調MRIで観察した髄内変化2010

    • Author(s)
      青田洋一、上杉昌章、中村直行、河井卓也、小林洋介、若山悠介、齋藤和行
    • Organizer
      第39回日本脊椎脊髄病学会
    • Place of Presentation
      高知
    • Year and Date
      2010-04-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 右性腺動脈の走行に関する発生学的考察2010

    • Author(s)
      寺山隼人、内藤宗和、曲寧、平井宗一、易勤、伊藤正裕
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岩手
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 腰仙部MRI診断のための局所解剖2009

    • Author(s)
      青田洋一
    • Organizer
      第13回臨床解剖研究会,シンポジウム-神経の臨床解剖-
    • Place of Presentation
      東京
    • Year and Date
      2009-09-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 急性期顔面神経麻痺に対する舌下神経縦二分割移行術2009

    • Author(s)
      梁井皎、白澤友裕、宮木孝昌
    • Organizer
      第13回臨床解剖研究会,シンポジウム-神経の臨床解剖-
    • Place of Presentation
      東京
    • Year and Date
      2009-09-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 腰仙部MRI診断のための局所解剖2009

    • Author(s)
      青田洋一
    • Organizer
      第13回臨床解剖研究会シンポジウム-神経の臨床解剖-
    • Place of Presentation
      東京
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 急性期顔面神経麻痺に対する舌下神経縦二分割移行術2009

    • Author(s)
      梁井皎、白澤友裕、宮木孝昌
    • Organizer
      第13回臨床解剖研究会シンポジウム-神経の臨床解剖-
    • Place of Presentation
      東京
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 精巣自己免疫における抗原解析2009

    • Author(s)
      寺山隼人、内藤宗和、平井宗一、曲寧、伊藤正裕
    • Organizer
      日本解剖学会関東支部第19回懇話会・シンポジウム-生殖系の発生と分子動態-
    • Place of Presentation
      千葉大学
    • Year and Date
      2009-06-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 精巣自己免疫における抗原解析2009

    • Author(s)
      寺山隼人、内藤宗和、平井宗一、曲寧、伊藤正裕
    • Organizer
      日本解剖学会関東支部第19回懇話会・シンポジウム-生殖系の発生と分子動態-
    • Place of Presentation
      千葉、千葉大学
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 免疫学的保護器官である精巣への異種生殖細胞移植の試み2009

    • Author(s)
      曲寧, 伊藤正裕, et al
    • Place of Presentation
      岡山理科大学
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] マウスにおける自己免性精巣炎を引き起こす自己抗原の解析2009

    • Author(s)
      寺山隼人, et al
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山理科大学
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス新生児期エストロゲン投与による精路系の炎症惹起2009

    • Author(s)
      内藤宗和, et al
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山理科大学
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス自己免疫性精子形成障害モデルの終末期の解析2009

    • Author(s)
      平井宗一, et al
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山理科大学
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス自己免疫性精巣炎を引き起こす自己抗原のプロテオーム解析2008

    • Author(s)
      寺山隼人, et al
    • Organizer
      第23回日本生殖免疫学会総会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-12-06
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス自己免疫性精巣炎を引き起こす自己抗原の遺伝学的解析2008

    • Author(s)
      平井宗一, et al
    • Organizer
      第23回日本生殖免疫学会総会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-12-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 新生児期エストロゲン投与による精路系の炎症惹起2008

    • Author(s)
      内藤宗和, et al
    • Organizer
      第23回日本生殖免疫学会総会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-12-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of target antigens for testicular autoimmunity in mice2008

    • Author(s)
      寺山隼人, et al
    • Organizer
      第53回日本生殖医学会総会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-10-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Morphological responses in the testis, epidydimis and vas deferens following neonatal estrogen treatment in mice.2008

    • Author(s)
      内藤宗和, et al
    • Organizer
      第53回日本生殖医学会総会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-10-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 副中結腸動脈、脾動脈から起こる横行結腸動脈2008

    • Author(s)
      宮木孝昌、阿刀木江沙吾提、斉藤敏之、伊藤正裕
    • Organizer
      臨床解剖研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-12
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Morphological responses in the testis, epidydimis and vas deferens following neonatal estrogen treatment in mice.2008

    • Author(s)
      内藤宗和, et al
    • Organizer
      日本アンドロロジー学会第27回学術大会および第13回精子形成・精巣毒性研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-07-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of target antigens for testicular autoimmunity in mice.2008

    • Author(s)
      平井宗一, et al
    • Organizer
      日本アンドロロジー学会第27回学術大会および第13回精子形成・精巣毒性研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-07-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Morphological responses in the testis, epidydimis and vas deferens following neonatal estrogen treatment in mice.2008

    • Author(s)
      Naito M, et al
    • Organizer
      28th Annual Meeting American Society for Reproductive Immunology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2008-06-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Distribution of blood and lymphatic vessels in murine epididymis2008

    • Author(s)
      平井宗一, et al
    • Organizer
      28th Annual Meeting American Society for Reproductive Immunology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2008-06-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Safe and effective transarticular screwing method in the mid or lower cervical spine.2008

    • Author(s)
      Aota Y, Honda A, Toguchi A, Nakamura J, et al
    • Organizer
      Euro Cervical Spine Research Society
    • Place of Presentation
      Geneva
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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