Novel therapy for metastatic sarcoma to the lung using extracellular matrix protein : decorin.
| Project/Area Number |
20591752
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Mie University |
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Principal Investigator |
MATSUMINE Akihiko Mie University, 大学院・医学系研究科, 准教授 (00335118)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Atsumasa 三重大学, 学長 (40176681)
KUSUZAKI Katsuyuki 京都府立研究開発センタ, 特認教授 (30177993)
WAKABAYASHI Hiroki 三重大学, 医学部附属病院, 講師 (50362687)
KUMAMOTO Tadashi 三重大学, 大学院・医学系研究科, 助教 (50362348)
AKEDA Koji 三重大学, 医学部附属病院, 助教 (20422826)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | デコリン / 細胞外基質タンパク / 悪性骨軟部腫瘍 / 肉腫 / 遠隔転移 / 肺転移 / 腫瘍増殖 / 治療 / 抗腫瘍効果 |
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| Research Abstract |
We discovered that decorin suppress lung metastasis of osteosarcoma and bone metastasis of breast cancer. Furthermore, we showed that minimum active region for anti-tumor effect may be the TGF-b binding site which exists in the core protein of decorin. Decorin is a natural product and has no immunogenicity. Therefore, these results suggest that decorin represents the new therapeutic modality to prevent pulmonary metastasis in osteosarcoma.
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Report
(4 results)
Research Products
(142 results)
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[Journal Article] Clinical outcomes of the KYOCERA Physio Hinge Total Knee System Type III after the resection of a bone and soft tissue tumor of the distal part of the femur.2011
Author(s)
Matsumine A, Ueda T, Sugita T, Yazawa Y, Isu K, Kawai A, Abe S, Yakushiji T, Hiraga H, Sudo A, Uchida A.
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Related Report
Peer Reviewed
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[Journal Article] Expression of ADAMTS4 in Ewing's sarcoma.2010
Author(s)
Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y, Kitamura T,Nosaka T.
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Journal Title
Int J Oncol 37
Pages: 569-581
Related Report
Peer Reviewed
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[Journal Article] The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas.2010
Author(s)
Niimi R, Matsumine A, Iino T, Murata T, Shintani K, Nakazora S, Nakamura T,Uehara Y, Kusuzaki K, Akiyama T, Uchida A.
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Journal Title
Oncol Rep. 23
Pages: 631-638
Related Report
Peer Reviewed
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[Journal Article] Multiple cutaneous squamous cell carcinomas in a patient withinterferon gamma receptor 2 (IFN gamma R2) deficiency.2010
Author(s)
Toyoda H, Ido M, Nakanishi K, Nakano T, Kamiya H, Matsumine A, Uchida A, Mizutani H, de Beaucoudrey L, Vogt G, Boisson-Dupuis S, Bustamante J, CasanovaJL, Komada Y.
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Journal Title
J Med Genet. 47
Pages: 631-634
Related Report
Peer Reviewed
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[Journal Article] Differentiation between neurofibromas and malignant peripheral nerve sheath tumors in neurofibromatosis 1 evaluated by MRI.2009
Author(s)
Matsumine A, Kusuzaki K, Nakamura T, Nakazora S, Niimi R, Matsubara T, Uchida K, Murata T, Kudawara I, Ueda T, Naka N, Araki N, Maeda M, Uchida A.
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Journal Title
J Cancer Res Clin Oncol. 135
Pages: 891-900
Related Report
Peer Reviewed
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[Journal Article] A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabdomyosarcomas.2009
Author(s)
Matsubara T, Kusuzaki K, Matsumine A, Murata H, Satonaka H, Shintani K, Nakamura T, Hosoi H, Iehara T, Sugimoto T, Uchida A.
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Journal Title
Oncol Rep. 21
Pages: 89-94
Related Report
Peer Reviewed
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[Journal Article] Decorin suppresses lung metastases of murine osteosarcoma.2008
Author(s)
Shintani K, Matsumine A, Kusuzaki K, Morikawa J, Matsubara T, Wakabayashi T, Araki K, Satonaka H, Wakabayashi H, Iino T, Uchida A.
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Journal Title
Oncol Rep. 19
Pages: 1533-1539
Related Report
Peer Reviewed
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[Journal Article] Usefulness of limb salvage surgery for bone and soft tissue sarcomas of the distal lower leg.2008
Author(s)
Niimi R, Matsumine A, Kusuzaki K, Kuratsu S, Araki N, Aoki Y, Ueda T, Kudawara I, Myoui A, Ieguchi M, Hashimoto N, Yoshikawa H, Uchida A.
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Journal Title
J Cancer Res Clin Oncol. 134
Pages: 1087-1095
Related Report
Peer Reviewed
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[Journal Article] Prognostic implication of SYT-SSX fusion type in synovial sarcoma : a multi-institutional retrospective analysis in Japan.2008
Author(s)
Takenaka S, Ueda T, Naka N, Araki N, Hashimoto N, Myoui A, Ozaki T, Nakayama T, Toguchida J, Tanaka K, Iwamoto Y, Matsumine A, Uchida A, Ieguchi M, Kaya M, Wada T, Baba I, Kudawara I, Aoki Y, Yoshikawa H.
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Journal Title
Oncol Rep. 19
Pages: 467-476
Related Report
Peer Reviewed
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[Presentation] Fibulin-3 suppress the chondrogenic differentiation by preventing the cleavage of N-cadherin2009
Author(s)
Nakazora S, Matsumine A, Wakabayashi T, Niimi R, Nakamura T, Matsubara T, Nakoshi R, Iino T, Akeda K, Hasegawa M, Kusuzaki K, Sudo A, Uchida A.
Organizer
55th Annual Meeting of the Orthopaedic Research Society
Place of Presentation
LasVegas
Related Report
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[Presentation] Limb salvage surgery for bone and soft tissue of the distal lower leg2008
Author(s)
Niimi R, Matsumine A, Kusuzaki K, Nakamura T, Nakazora S, Kuratsu S, Araki N, Aoki Y, Ueda T, Kudawara I, Myoui A, Ieguchi M, Hashimoto N, Yoshikawa H, Uchida A.
Organizer
7th. Asia Pacific Musculoskeletal Tumor Society Meeting
Place of Presentation
Beijing
Related Report
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