| Project/Area Number |
20591752
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Mie University |
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Principal Investigator |
MATSUMINE Akihiko Mie University, 大学院・医学系研究科, 准教授 (00335118)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Atsumasa 三重大学, 学長 (40176681)
KUSUZAKI Katsuyuki 京都府立研究開発センタ, 特認教授 (30177993)
WAKABAYASHI Hiroki 三重大学, 医学部附属病院, 講師 (50362687)
KUMAMOTO Tadashi 三重大学, 大学院・医学系研究科, 助教 (50362348)
AKEDA Koji 三重大学, 医学部附属病院, 助教 (20422826)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | デコリン / 細胞外基質タンパク / 悪性骨軟部腫瘍 / 肉腫 / 遠隔転移 / 肺転移 / 腫瘍増殖 / 治療 / 抗腫瘍効果 |
|---|
| Research Abstract |
We discovered that decorin suppress lung metastasis of osteosarcoma and bone metastasis of breast cancer. Furthermore, we showed that minimum active region for anti-tumor effect may be the TGF-b binding site which exists in the core protein of decorin. Decorin is a natural product and has no immunogenicity. Therefore, these results suggest that decorin represents the new therapeutic modality to prevent pulmonary metastasis in osteosarcoma.
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