| Project/Area Number |
20591757
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
MATSUO Toshihiro Hiroshima University, 大学院・医歯薬学総合研究科, 寄附講座助教 (90397977)
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| Co-Investigator(Kenkyū-buntansha) |
OCHI Mitsuo 広島大学, 病院, 教授 (70177244)
HIYAMA Eiso 広島大学, 自然科学研究支援開発センター, 教授 (00218744)
SHIMOSE Shouji 広島大学, 大学院・医歯薬学総合研究科, 准教授 (30304439)
KUBO Tadahiko 広島大学, 病院, 講師 (70397959)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 遺伝子 / 癌 |
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| Research Abstract |
In this study, we investigated the antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines. Both telomerase activity loss and sufficient telomere shortening are necessary to inhibit cell growth in telomerase positive cells. TMPyP4 did not induce telomere shortening but significantly inhibited the growth in extremely longer telomere-cells, indicating the antitumor effect of TMPyP4 may be related to DNA damage, independent on telomere length. Our results may indicate telomerase inhibitors such asTMPyP4 are novel adjuvant therapy for osteosarcoma patients in the near future.
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