Establishment of anti-angiogenic therapy for soft tissue sarcomsas

• Project/Area Number: 20591762
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Sapporo Medical University
• Principal Investigator: KAYA Mitsunori Sapporo Medical University, 医学部, 講師 (10398315)
• Co-Investigator(Kenkyū-buntansha): WADA Takuro 札幌医科大学, 道民医療推進学講座, 特任教授 (00244369) ; YAMASHITA Toshihiko 札幌医科大学, 医学部, 教授 (70244366)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 軟部肉腫 / 遠隔転移 / 局所浸潤 / 血管新生 / 局所侵潤

Research Abstract

To establish the anti-angiogenic therapy for soft tissue sarcomas, the risk factors of the local recurrence of myxofibrosarcoma were retrospectively analyzed. Inadequate surgical margins and bone and/or joint attachment were associated with an increased recurrence rate. Further evaluation of the role of angiogenesis to invasiveness of myxofibrosarcoma will be necessary for the establishment of anti-angiogenic therapy for soft tissue sarcoma.

Research Products

• [Journal Article] The leve of vascular endothelial growth factor as predictor of a poor prognosis in osteosarcoma. (2009)
  • Author(s): DKava M, Wada T, Nagoya S, Sasaki M, Matsumura T, Yamashita T.
  • Journal Title: J Bone Joint Surg 91B Pages: 1142-1147
  • Peer Reviewed
• [Journal Article] The level of vascular endothelial growth factor as a predictor of a poor prognosis in osteosarcoma (2009)
  • Author(s): Kaya M
  • Journal Title: J Bone Joint Surg 91B Pages: 1142-1147
  • Peer Reviewed
• [Journal Article] MRI and Histological Evaluation of the Infiltrative Growth Pattern of Myxofibrosarcoma. (2008)
  • Author(s): Kaya M, et al
  • Journal Title: Skeletal Radiology 37 Pages: 1085-1090
  • Peer Reviewed
• [Presentation] High serum levels of VEGF predict poor prognosis for patients with osteosarcoma : A prospective study 2010 (2011)
  • Author(s): Kava M, Wada T Nagoya S, Sasaki M, Emori M, Yamashita T.
  • Organizer: 78th American Academy of Orthopedic Surgeons
  • Place of Presentation: San Diego, U S A
• [Presentation] Risk Factors for local recurrence of myxofibrosarcoma (2010)
  • Author(s): Kava M, Wada T Nagoya S, Sasaki M, Emori M, Yamashita T.
  • Organizer: 2010 Connective tissue Oncology Society Meeting.
  • Place of Presentation: Paris
  • Year and Date: 2010-11-11
• [Presentation] High serum levels of VEGF predict poor prognosis for patients with osteosarcoma : A prospective study (2010)
  • Author(s): Kava M, Wada T Nagoya S, Sasaki M Emori M, Yamashita T.
  • Organizer: 2010 Connective tissue Oncology Society Meeting
  • Place of Presentation: Paris
  • Year and Date: 2010-11-11
• [Presentation] Risk Factors for local recurrence of zmyxofibrosarcoma (2010)
  • Author(s): Kaya M, et al.
  • Organizer: 2010 Connective tissue Oncology Society Meeting
  • Place of Presentation: Paris
  • Year and Date: 2010-11-11
• [Presentation] High serum levels of VEGF predict poor prognosis for patients with osteosarcoma : A prospective study. (2010)
  • Author(s): Kaya M, et al.
  • Organizer: 2010 Connective tissue Oncology Society Meeting
  • Place of Presentation: Paris
  • Year and Date: 2010-11-11
• [Presentation] Risk Factors for local recurrence of zmyxofibrosarcoma. (2010)
  • Author(s): Kava M, Wada T Nagoya S, Sasaki M, Emori M, Yamashita T.
  • Organizer: The 20^<th> Japanese-Korean Comibined Orthopaedic Symposium
  • Place of Presentation: Ibusuki
  • Year and Date: 2010-06-03
• [Presentation] Risk Factors for local recurrence of zmyxofibrosarcoma (2010)
  • Author(s): Kaya M, et al.
  • Organizer: The 20^<th> Japanese-Korean Combined Orthopaedic Symposium
  • Place of Presentation: 指宿
  • Year and Date: 2010-06-03
• [Presentation] 血清VEGF濃度は骨肉腫症例の予後予測因子である : 前向き検討 (2009)
  • Author(s): 加谷光規, ら
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-11-06
• [Presentation] Myxofibrosarcoma 局所再発の危険因子 (2009)
  • Author(s): 加谷光規, ら
  • Organizer: 第47回日本癌治療学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-23
• [Presentation] Radiological and Histoogical evaluation of the infiltrative growth pattern of myxofibrosarcom (2009)
  • Author(s): Kaya M, et al
  • Organizer: International Symposium of : Lim Salvage and the Musculoskeletal Tumor Society
  • Place of Presentation: Boston, U S A
  • Year and Date: 2009-09-23
• [Presentation] Myxofibrosarcoma 局所再発の危険因子 (2009)
  • Author(s): 加谷光規, ら
  • Organizer: 第42回日本整形外科学会・骨軟部腫瘍学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2009-07-17
• [Presentation] Radiological and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma (2009)
  • Author(s): Kava M, Wada T. Nagoya S, Sasaki M, Yamashita T.
  • Organizer: International Symposium of : Lim Salvage and the Musculoskeletal Tumor Society
  • Place of Presentation: Boston, U S A
• [Presentation] Radiological and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma (2009)
  • Author(s): Kava M, Wada T Nagoya S, Sasaki M, Matsuura T, Kosukegawa I, Yamashita T.
  • Organizer: 76th American Academy of Orthopedic Surgeons
  • Place of Presentation: Las Vegas, USA
• [Presentation] Radiological and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma (2009)
  • Author(s): Kaya M, et al
  • Organizer: American Academy of Orthopaedic Surgeons
  • Place of Presentation: LasVegas