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Studies on the operative technique and the cytokines required to reproduce a normal bone-ligament junction in the knee ligament reconstruction

Research Project

Project/Area Number 20591769
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKurume University

Principal Investigator

SOEJIMA Takashi  久留米大学, 医学部, 講師 (90279208)

Co-Investigator(Kenkyū-buntansha) NAGATA Kensei  久留米大学, 医学部, 教授 (50140687)
Research Collaborator MURAKAMI Hidetaka  久留米大学, 医学部, 講師
KANAZAWA Tomonoshin  久留米大学, 医学部, 助教
KATOU Damichihiro  久留米大学, 医学部, 助教
TABUCHI Kousuke  久留米大学, 大学院, 大学院生
NOYAMA Megumi  久留米大学, 大学院, 大学院生
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords膝 / 靭帯 / 再建術 / 骨.靭帯移行部 / ACL / PCL / 靭帯再建術 / 器官形成 / 内軟骨骨化 / 組織学的変化 / コラーゲン / Sox-9 / 骨靭帯移行部 / 骨髄幹細胞 / 骨-靭帯移行部 / 膝前十字靭帯 / 膝前十字靱帯
Research Abstract

On immunohistological search of the rat, although ligament insertion site is completely bipolarized into the ligament cell which produces type I collagen at a viviparous period and the epiphysial cartilage cell which produces type II collagen, both cells re-arrange regularly to a fibrous direction after birth. In the boundary part, it seemed that a part of ligament cell transmuted into the cartilage cell and a part of cartilage cell transmuted into the ligament cell, with revelation of Sox9. (2) A direction of the anchor fiber came to agree with the mechanical axis of the grafted tendon when we changed the operation method from the conventional bone-tunnel method to our original method without bone-tunnel, although the tendon-bone junction was a fibrous union. (3) The cartilaginous bone-tendon junction through the layer of type II collagen which resembled to a normal bone-tendon junction was found by some individuals, when the bone marrow-derived mesenchymal stem cell which has multipotency and/or Sox 9 which is considered to be one of the key-factors by the experiment-1 were introduced into the our reconstruction model which established by the experiment-2.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (39 results)

All 2012 2011 2010 2009 2008

All Journal Article (11 results) (of which Peer Reviewed: 7 results) Presentation (28 results)

  • [Journal Article] Inducement of semitendinosus tendon regeneration to the pes anserinus after its harvest for anterior cruciate ligament reconstruction ; a new inducer grafting technique2012

    • Author(s)
      Murakami H, Soejima T, Inoue T, Kanazawa T, Noguchi K, Katouda M, Tabuchi K, Noyama M, Yasunaga H, Nagata K
    • Journal Title

      Sports Med Arthrosc Rehabil Ther Technol

      Volume: 4 Issue: 1 Pages: 17-17

    • DOI

      10.1186/1758-2555-4-17

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between thickness of the anteromedial bundle and thickness of the posterolateral bundle in the normal ACL2011

    • Author(s)
      Katouda M, Soejima T, Kanazawa T, Tabuchi K, Yamaki K, Nagata K
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc

      Volume: 19(8) Pages: 1293-1298

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hybrid exercise prevents muscle atrophy in association with a distinct gene expression pattern2011

    • Author(s)
      Matsugaki T, Shiba N, Kohno S, Nikawa T, Hirasaka K, Okumura Y, Ishidoh K, Soejima T, Yoshimitsu K, Nagata K
    • Journal Title

      Kurume Med J

      Volume: 57(4) Pages: 101-108

    • NAID

      130001055545

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between tnickness of the anteromedial bundle and thickness of the posterolateral bundle in the normal ACL2011

    • Author(s)
      Michihiro Katouda
    • Journal Title

      Knee Surg Sports traumatol Athrosc

      Volume: 19(8) Pages: 1293-1298

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "Hybrid exercise" prevents muscle atrophy in association with a distinct gene expression pattern2011

    • Author(s)
      Matsugaki T
    • Journal Title

      Kurume Med J

      Volume: 57(4) Pages: 101-108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between thickness of the anteromedial bundle and thickness of tha posterolateral bundle in the normal ACL Knee Surg Sports Traumatol Arthrosc.2011

    • Author(s)
      M.Katouda, T.Soejima,T.Kanazawa, et al.
    • Journal Title

      Online First.Feb 8[Epub ahead of print]

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Relationship between thickness of the anteromedial bundle an thickness of the posterolateral bundle in the normal ACL.2011

    • Author(s)
      Michihiro Katouda
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc

      Volume: Feb 8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 家兎半腱様筋腱採取後の解剖学的付着部への再生2010

    • Author(s)
      田渕幸祐, 副島崇, 村上秀孝, 金澤知之進, 野山めぐみ, 永田見生
    • Journal Title

      JOSKAS

      Volume: 35巻 Pages: 90-91

    • NAID

      10027615801

    • Related Report
      2011 Final Research Report
  • [Journal Article] ACL再建術における誘導枝を用いた半腱様筋腱再生: 3DCTでの検討2010

    • Author(s)
      村上秀孝, 副島崇, 井上貴司, 金澤知之進, 野口幸志, 加藤田倫宏, 田渕幸祐, 野山めぐみ, 安永英樹, 永田見生
    • Journal Title

      JOSKAS

      Volume: 35巻 Pages: 92-93

    • NAID

      10027615806

    • Related Report
      2011 Final Research Report
  • [Journal Article] 半腱様筋腱単独採取と半腱様筋腱・薄筋腱同時採取後の腱再生膝2008

    • Author(s)
      副島崇, 村上秀孝, 井上貴司, 金澤知之進, 野口幸志, 加藤田倫宏, 田渕幸祐, 野山めぐみ, 永田見生
    • Volume
      33巻
    • Pages
      302-306
    • Related Report
      2011 Final Research Report
  • [Journal Article] 前十字靭帯再建術における解剖学的半腱様筋腱再生の試み膝2008

    • Author(s)
      村上秀孝, 副島崇, 井上貴司, 金澤知之進, 野口幸志, 加藤田倫宏, 田渕幸祐, 野山めぐみ, 安永英樹, 永田見生
    • Volume
      33巻
    • Pages
      43-47
    • Related Report
      2011 Final Research Report
  • [Presentation] Histological analysis on the tendon-to-bone healing utilizing bone marrowderived MSCs in ACL reconstruction without bone tunnel model2012

    • Author(s)
      Kanazawa T, Soejima T, Noguchi K, Tabuchi K, Noyama M, Nagata K
    • Organizer
      58th Annual Meeting of the Orthopaedic Reserch Society
    • Place of Presentation
      San Francisco
    • Year and Date
      2012-02-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Histological analysis on the tendon-to-bone healing utilizing bone marrow-derived MSCs in ACL reconstruction without bone tunnel model2012

    • Author(s)
      Tomonoshin Kanazawa
    • Organizer
      2012 Annual meating of Orthopaedic Research Sociaty
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2012-02-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨孔法によらない骨-移植腱間錨着の研究2011

    • Author(s)
      金澤知之進, 副島崇, 野口幸志, 田渕幸祐, 野山めぐみ, 永田見生
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋市
    • Year and Date
      2011-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] ACL再建術における誘導枝を用いた半腱様筋腱再生:筋腹短縮と屈曲トルクについて2010

    • Author(s)
      村上秀孝, 副島崇, 井上貴司, 金澤知之進, 野口幸志, 田渕幸祐, 安永英樹, 永田見生
    • Organizer
      JOSKAS
    • Place of Presentation
      那覇市
    • Year and Date
      2010-07-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Results of the triple and double bundle PCL reconstruction in the multipleligament injured knee2010

    • Author(s)
      Soejima T, Inoue T, Kanazawa T, Noguchi K, Tabuchi K, Noyama M, Nagata K
    • Organizer
      14th ESSKA Congress
    • Place of Presentation
      Oslo
    • Year and Date
      2010-06-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Immunohistological changes of the tibial insertion site of ACL in the organogenetic period of the rat2010

    • Author(s)
      Noyama M, Soejima T, Kanazawa T, Noguchi K, Tabuchi K, Nagata K
    • Organizer
      14th ESSKA Congress
    • Place of Presentation
      Oslo
    • Year and Date
      2010-06-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Immunohistological changes of the tibial insertion site of anterior cruciate ligament in the organogenetic period of the rat2010

    • Author(s)
      Megumi Noyama
    • Organizer
      14th ESSKA Congress 2010
    • Place of Presentation
      Oslo, Norway
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunohistological changes of the tibial insertion site of ACL in the organogenetic period of the rat.2010

    • Author(s)
      M.Noyama, T.Soejima, T.Kanazawa, et al.
    • Organizer
      14^<th> ESSKA Congress
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Results of the triple and double bundle PCL reconstruction in the multiple-ligament injured knee.2010

    • Author(s)
      T.Soejima, et al.
    • Organizer
      14^<th> ESSKA Congress
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 骨-移植腱間錨着の免疫組織学的検討2009

    • Author(s)
      金澤知之進, 副島崇, 村上秀孝, 井上貴司, 田渕幸祐, 野口幸志, 加藤田倫宏, 野山めぐみ, 永田見生
    • Organizer
      日本整形外科学会基礎学術集会(パネルディスカッション)
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-06
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット膝前十字靭帯付着部の器官形成器における組織学的変化2009

    • Author(s)
      野山めぐみ, 副島崇, ほか
    • Organizer
      第24回日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨―移植腱間錨着の免疫組織学的検討2009

    • Author(s)
      金澤知之進, 副島崇, ほか
    • Organizer
      第24回日本整形外科学会基礎学術集会(パネルディスカッション)
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット膝前十字靭帯付着部の器官形成期における組織学的変化2009

    • Author(s)
      野山めぐみ, 副島崇, 金澤知之進, 野口幸志, 田渕幸祐, 永田見生
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Natural development of the tibial ACL insertion in rat knee2009

    • Author(s)
      Noyama M, Soejima T, Murakami H, Inoue T, Kanazawa T, Noguchi K, Katouda M, Tabuchi K, Nagata K
    • Organizer
      6th SICOT
    • Place of Presentation
      Thai
    • Year and Date
      2009-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Semitendinosus regrowth to anatomical tibial insertion in rabbit2009

    • Author(s)
      Tabuchi K, Soejima T, Murakami H, Kanazawa T, Noyama M, Nagata K
    • Organizer
      6th SICOT
    • Place of Presentation
      Thai
    • Year and Date
      2009-10-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 家兎半腱様筋腱採取後の解剖学的付着部への再生2009

    • Author(s)
      田渕幸祐, 副島崇, 村上秀孝, 井上貴司, 金澤知之進, 野口幸志, 加藤田倫宏, 野山めぐみ, 安永英樹, 永田見生
    • Organizer
      JOSKAS
    • Place of Presentation
      札幌
    • Year and Date
      2009-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation] ACL再建術における誘導枝を用いた解剖学的半腱様筋腱再生の試み-3D-CTでの検討-2009

    • Author(s)
      村上秀孝, 副島崇, 井上貴司, 金澤知之進, 野口幸志, 加藤田倫宏, 田渕幸祐, 野山めぐみ, 安永英樹, 永田見生
    • Organizer
      日本整形外科学会
    • Place of Presentation
      福岡市
    • Year and Date
      2009-05-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Mechanically induced holes in the grafted tendon hasten cell infiltration into intra-osseous graft material following ACL reconstruction in rodent model2009

    • Author(s)
      Lovric V, Kanazawa T, Nakamura Y, Yu Y, Oliver R, Soejima T, Nagata K, Walsh W
    • Organizer
      日本整形外科学会
    • Place of Presentation
      福岡市
    • Year and Date
      2009-05-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional regeneration of the semitendinosus tendon in ACL reconstruction with hamstring autograft : a new technique of inducer grafting2009

    • Author(s)
      Murakami H, Soejima T, Inoue T, Kanazawa T, Noguchi K, Katouda M, Tabuchi K, Noyama M, Yasunaga H, Nagata K
    • Organizer
      ISAKOS
    • Place of Presentation
      Osaka
    • Year and Date
      2009-04-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Mechanically induced holes in the grafted tendon enhance and hasten cell infiltration into intraosseous graft material following ACL reconstruction in rodent model2009

    • Author(s)
      Lovric V, Kanazawa T, Nakamura Y, Yu Y, Oliver Y, Soejima T, Nagata K, Walsh W
    • Organizer
      55th Annual Meeting of the Orthopaedic Reserch Society
    • Place of Presentation
      Las Vegas
    • Year and Date
      2009-02-23
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット膝前十字靭帯付着部の器官形成期における組織学的変化2009

    • Author(s)
      野山めぐみ、副島崇, ほか
    • Organizer
      第24回日本整形外科学会基礎学術集会
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 骨-移植腱間錨着の免疫組織学的検討2009

    • Author(s)
      金澤知之進、副島崇, ほか
    • Organizer
      第24回日本整形外科学会基礎学術集会(パネルディスカッション)
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] ACL再建術における誘導枝を用いた機能的半腱様筋腱再生への試み2008

    • Author(s)
      田渕幸祐, 副島崇, 村上秀孝, 井上貴司, 金澤知之進, 野口幸志, 加藤田倫宏, 野山めぐみ, 安永英樹, 永田見生
    • Organizer
      日本臨床スポーツ医学会
    • Place of Presentation
      幕張
    • Year and Date
      2008-11-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 家兎関節外靭帯再建モデルにおける移植腱-骨孔間接着様式の免疫組織学的評価2008

    • Author(s)
      田渕幸祐, 副島崇, 金澤知之進, 加藤田倫宏, 野山めぐみ, 井上貴司, 野口幸志, 村上秀孝, 永田見生
    • Organizer
      JOSKAS
    • Place of Presentation
      東京
    • Year and Date
      2008-06-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 半腱様筋腱単独及び半腱様筋腱・薄筋腱同時採取後の腱再生の検証2008

    • Author(s)
      副島崇, 村上秀孝, 井上貴司, 金澤知之進, 野口幸志, 加藤田倫宏, 田渕幸祐, 野山めぐみ, 永田見生
    • Organizer
      JOSKAS
    • Place of Presentation
      東京
    • Year and Date
      2008-06-14
    • Related Report
      2011 Final Research Report
  • [Presentation] ACL再建術における機能的半腱様筋腱再生への試み2008

    • Author(s)
      村上秀孝, 副島崇, 井上貴司, 金澤知之進, 野口幸志, 加藤田倫宏, 田渕幸祐, 野山めぐみ, 安永英樹, 永田見生
    • Organizer
      JOSKAS
    • Place of Presentation
      東京
    • Year and Date
      2008-06-14
    • Related Report
      2011 Final Research Report
  • [Presentation] An immunohistological study of changes in the collagen composition of tendon grafts in the bone tunnel2008

    • Author(s)
      Tabuchi K, Soejima T, Kanazawa T, Katouda M, Inoue T, Murakami H, Nagata K
    • Organizer
      ESSKA
    • Place of Presentation
      Porto
    • Year and Date
      2008-05-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Measurement of the mid-substance circumference of the anteromedial and postrolateral bundle in the normal anterior cruciate ligament2008

    • Author(s)
      Katouda M, Soejima T, Yamaki K, Inoue T, Tabuchi K, Noyama M, Kanazawa T, Murakami H, Noguchi K, Nagata K
    • Organizer
      ESSKA
    • Place of Presentation
      Porto
    • Year and Date
      2008-05-19
    • Related Report
      2011 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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