Studies on the operative technique and the cytokines required to reproduce a normal bone-ligament junction in the knee ligament reconstruction
| Project/Area Number |
20591769
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGATA Kensei 久留米大学, 医学部, 教授 (50140687)
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| Research Collaborator |
MURAKAMI Hidetaka 久留米大学, 医学部, 講師
KANAZAWA Tomonoshin 久留米大学, 医学部, 助教
KATOU Damichihiro 久留米大学, 医学部, 助教
TABUCHI Kousuke 久留米大学, 大学院, 大学院生
NOYAMA Megumi 久留米大学, 大学院, 大学院生
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 膝 / 靭帯 / 再建術 / 骨.靭帯移行部 / ACL / PCL / 靭帯再建術 / 器官形成 / 内軟骨骨化 / 組織学的変化 / コラーゲン / Sox-9 / 骨靭帯移行部 / 骨髄幹細胞 / 骨-靭帯移行部 / 膝前十字靭帯 / 膝前十字靱帯 |
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| Research Abstract |
On immunohistological search of the rat, although ligament insertion site is completely bipolarized into the ligament cell which produces type I collagen at a viviparous period and the epiphysial cartilage cell which produces type II collagen, both cells re-arrange regularly to a fibrous direction after birth. In the boundary part, it seemed that a part of ligament cell transmuted into the cartilage cell and a part of cartilage cell transmuted into the ligament cell, with revelation of Sox9. (2) A direction of the anchor fiber came to agree with the mechanical axis of the grafted tendon when we changed the operation method from the conventional bone-tunnel method to our original method without bone-tunnel, although the tendon-bone junction was a fibrous union. (3) The cartilaginous bone-tendon junction through the layer of type II collagen which resembled to a normal bone-tendon junction was found by some individuals, when the bone marrow-derived mesenchymal stem cell which has multipotency and/or Sox 9 which is considered to be one of the key-factors by the experiment-1 were introduced into the our reconstruction model which established by the experiment-2.
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Report
(6 results)
Research Products
(39 results)
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[Presentation] 骨-移植腱間錨着の免疫組織学的検討2009
Author(s)
金澤知之進, 副島崇, 村上秀孝, 井上貴司, 田渕幸祐, 野口幸志, 加藤田倫宏, 野山めぐみ, 永田見生
Organizer
日本整形外科学会基礎学術集会(パネルディスカッション)
Place of Presentation
横浜
Year and Date
2009-11-06
Related Report
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