Development of target therapy for SSX of sarcoma metastasis
| Project/Area Number |
20591771
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses |
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Principal Investigator |
YOSHIOKA Kiyoko Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses, 研究所, 研究員 (40342993)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Kazuyuki 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 部長 (20301806)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIKAWA Hideki 大阪大学, 大学院・医学系研究科器官制御外科学, 教授 (60191558)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | SSX / 骨軟部腫瘍 / 浸潤 / 転移 / lung metastasis / invasion / MMP-1 / siRNA / LC/MS/MS / ChIP / LC / MS / osteosarcoma |
|---|
| Research Abstract |
The SSX genes were initially identified as fusion partners to the SS18 gene in synovial sarcoma. Besides adult human testis, SSX genes were highly expressed in sarcoma, and positively correlated with clinical stage, especially the metastatic case present very high SSX expression. Our results suggested that SSXs would be novel proteins regulate cancer metastasis and potential molecular target(s) under clinical setting.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling2011
Author(s)
Sonoshita, M., Aoki, M., Fuwa, H., Aoki K., Hosogi, H., Sakai, Y., Hashida, H., Takabayashi, A., Sasaki, M., Robine, S., Itoh K., Yoshioka K., Kakizaki, F., Kitamura, T., Oshima, M., Taketo. M.M.
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Journal Title
Cancer Cell 19
Pages: 125-137
Related Report
Peer Reviewed
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[Journal Article] Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8.2010
Author(s)
Yui, Y., Itoh K., Yoshioka K., Naka N., Watanabe, M., Hiraumi, Y., Matsubara, H., Watanabe, K., Sano, K., Nakahata, T., Adachi, S.
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Journal Title
Clin Exp Metastasis 27
Pages: 619-630
Related Report
Peer Reviewed
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[Journal Article] Synovial Sarcoma Is a Stem Cell Malignancy.2010
Author(s)
Naka N., Takenaka S., Araki N., Miwa, T., Hashimoto, N., Yoshioka K., Joyama, S., Hamada, K., Tsukamoto, Y., Tomita, Y., Ueda, T., Yoshikawa, H., Itoh K.
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Journal Title
Stem Cells 28
Pages: 1119-1131
Related Report
Peer Reviewed
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[Journal Article] Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo.2010
Author(s)
Takenaka S., Naka N., Araki N., Hashimoto, N., Ueda, T., Yoshioka K.,, Yoshikawa, H., Itoh K.
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Journal Title
Int.J.Oncology 36(4)
Pages: 823-831
Related Report
Peer Reviewed
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[Journal Article]2010
Author(s)
吉岡潔子
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Journal Title
臨床整形外科(第42巻 第2号)最新基礎科学/知っておきたいSSX(synovial sarcoma X chromosome breakpoint)遺伝子(医学書院)
Pages: 168-171
Related Report
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[Journal Article]2008
Author(s)
吉岡潔子(日本がん転移学会編)
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Journal Title
がん転移研究の実験手法(金芳堂)
Pages: 195-200
Related Report
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