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Development of target therapy for SSX of sarcoma metastasis

Research Project

Project/Area Number 20591771
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionResearch Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses

Principal Investigator

YOSHIOKA Kiyoko  Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses, 研究所, 研究員 (40342993)

Co-Investigator(Kenkyū-buntansha) ITOH Kazuyuki  地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 部長 (20301806)
Co-Investigator(Renkei-kenkyūsha) YOSHIKAWA Hideki  大阪大学, 大学院・医学系研究科器官制御外科学, 教授 (60191558)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsSSX / 骨軟部腫瘍 / 浸潤 / 転移 / lung metastasis / invasion / MMP-1 / siRNA / LC/MS/MS / ChIP / LC / MS / osteosarcoma
Research Abstract

The SSX genes were initially identified as fusion partners to the SS18 gene in synovial sarcoma. Besides adult human testis, SSX genes were highly expressed in sarcoma, and positively correlated with clinical stage, especially the metastatic case present very high SSX expression. Our results suggested that SSXs would be novel proteins regulate cancer metastasis and potential molecular target(s) under clinical setting.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (49 results)

All 2011 2010 2009 2008 Other

All Journal Article (18 results) (of which Peer Reviewed: 13 results) Presentation (27 results) Remarks (4 results)

  • [Journal Article] Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling2011

    • Author(s)
      Sonoshita, M., Aoki, M., Fuwa, H., Aoki K., Hosogi, H., Sakai, Y., Hashida, H., Takabayashi, A., Sasaki, M., Robine, S., Itoh K., Yoshioka K., Kakizaki, F., Kitamura, T., Oshima, M., Taketo. M.M.
    • Journal Title

      Cancer Cell 19

      Pages: 125-137

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling2011

    • Author(s)
      Sonoshita, Masahiro
    • Journal Title

      Cancer Cell

      Volume: 19 Pages: 125-137

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨・軟部腫瘍の転移に関与する新規標的分子SSX2010

    • Author(s)
      吉岡潔子、伊藤和幸、中紀文、荒木信人、竹中聡
    • Journal Title

      整形・災害外科 53巻、No.12

      Pages: 1344-1345

    • Related Report
      2010 Final Research Report
  • [Journal Article] Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8.2010

    • Author(s)
      Yui, Y., Itoh K., Yoshioka K., Naka N., Watanabe, M., Hiraumi, Y., Matsubara, H., Watanabe, K., Sano, K., Nakahata, T., Adachi, S.
    • Journal Title

      Clin Exp Metastasis 27

      Pages: 619-630

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synovial Sarcoma Is a Stem Cell Malignancy.2010

    • Author(s)
      Naka N., Takenaka S., Araki N., Miwa, T., Hashimoto, N., Yoshioka K., Joyama, S., Hamada, K., Tsukamoto, Y., Tomita, Y., Ueda, T., Yoshikawa, H., Itoh K.
    • Journal Title

      Stem Cells 28

      Pages: 1119-1131

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo.2010

    • Author(s)
      Takenaka S., Naka N., Araki N., Hashimoto, N., Ueda, T., Yoshioka K.,, Yoshikawa, H., Itoh K.
    • Journal Title

      Int.J.Oncology 36(4)

      Pages: 823-831

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] SSX(synovial sarcoma X chromosome breakpoint)遺伝子2010

    • Author(s)
      吉岡潔子、中紀文、竹中聡、伊藤和幸
    • Journal Title

      臨床整形外科 45巻、Vol.2

      Pages: 168-171

    • Related Report
      2010 Final Research Report
  • [Journal Article] 骨・軟部腫瘍の転移に関与する新規標的分子SSX2010

    • Author(s)
      吉岡潔子
    • Journal Title

      整形・災害外科

      Volume: 53(12) Pages: 1344-1345

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Synovial Sarcoma Is a Stem Cell Malignancy2010

    • Author(s)
      Naka, Norifumi
    • Journal Title

      Stem Cells

      Volume: 28 Pages: 1119-1131

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM82010

    • Author(s)
      Yui, Yoshihiro
    • Journal Title

      Clin Exp Metastasis

      Volume: 27 Pages: 619-630

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synovial sarcoma is a stem cell malignancy2010

    • Author(s)
      Naka, Norifumi
    • Journal Title

      Stem Cells (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo2010

    • Author(s)
      Takenaka, Satoshi
    • Journal Title

      Int J Oncology 36

      Pages: 823-831

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      吉岡潔子
    • Journal Title

      臨床整形外科(第42巻 第2号)最新基礎科学/知っておきたいSSX(synovial sarcoma X chromosome breakpoint)遺伝子(医学書院)

      Pages: 168-171

    • Related Report
      2009 Annual Research Report
  • [Journal Article] IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts.2008

    • Author(s)
      Nakasaki, M., Yoshioka K., Miyamoto, Y., Sasaki, T., Yoshikawa, H., Itoh K.
    • Journal Title

      Bone 43

      Pages: 869-879

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line.2008

    • Author(s)
      Nishimura, Y., Yoshioka K., Bereczky, B., Itoh K.
    • Journal Title

      Molecular Cancer 7(42)

      Pages: 1-13

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line2008

    • Author(s)
      Nishimura, Yukio
    • Journal Title

      Molecular Cancer 7:42

      Pages: 1-13

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts2008

    • Author(s)
      Nakasaki, Manando
    • Journal Title

      Bone 43

      Pages: 869-879

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2008

    • Author(s)
      吉岡潔子(日本がん転移学会編)
    • Journal Title

      がん転移研究の実験手法(金芳堂)

      Pages: 195-200

    • Related Report
      2008 Annual Research Report
  • [Presentation] SSXの浸潤・転移におけるRac1-myosinの経路とMMP-1の関与2010

    • Author(s)
      吉岡潔子
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      リーガロイヤルホテル大阪(大阪府)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Final Research Report
  • [Presentation] SSXの浸潤・転移におけるRac-1-myosinの経路とMMP-1の関与2010

    • Author(s)
      吉岡潔子
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      リーガロイヤルホテル大阪(大阪府)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨・軟部腫瘍の肺転移に関与する分子標的SSX2010

    • Author(s)
      吉岡潔子
    • Organizer
      第43回日本整形外科学会 骨・軟部腫瘍学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨・軟部腫瘍の肺転移に関与する分子標的SSX2010

    • Author(s)
      吉岡潔子
    • Organizer
      第43回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒストン脱アセチル化酵素阻害剤・酪酸ナトリウムによるがん細胞浸潤の抑制2010

    • Author(s)
      吉岡潔子
    • Organizer
      第19回日本がん転移学会学術集会・総会
    • Place of Presentation
      金沢市文化ホール(石川県)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 骨・軟部腫瘍の肺転移に対する分子標的SSXの機能解析2009

    • Author(s)
      吉岡潔子
    • Organizer
      第24回日本整形外科学会基礎学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-11-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨・軟部腫瘍の肺転移に対する分子標的SSXの機能解析2009

    • Author(s)
      吉岡潔子
    • Organizer
      第24回日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] SSXの浸潤・転移におけるPARP-1、Histone H1、MMP-1の関与2009

    • Author(s)
      吉岡潔子
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] SSXの浸潤・転移におけるPARP-1、Histone H1、MMP1の関与2009

    • Author(s)
      吉岡潔子
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨軟部腫瘍の肺転移に対する分子標的SSXの機能解析2009

    • Author(s)
      吉岡潔子
    • Organizer
      第18回日本がん転移学会 学術集会・総会
    • Place of Presentation
      旭川グランドホテル(北海道)
    • Year and Date
      2009-07-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨軟部腫瘍の肺転移に対する分子標的SSXの機能解析2009

    • Author(s)
      吉岡潔子
    • Organizer
      第18回日本がん転移学会学術集会・総会
    • Place of Presentation
      旭川
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨・軟部腫瘍の肺転移に対する分子標的SSXの機能解析2009

    • Author(s)
      吉岡潔子
    • Organizer
      第42回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-07-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨・軟部腫瘍の肺転移に対する分子標的SSXの機能解析2009

    • Author(s)
      吉岡潔子
    • Organizer
      第42回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-07-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] SSX regulate cancer invasion via PARP-1, Histone H1 and MMP-1 signaling.2008

    • Author(s)
      Itoh, Kazuyuki
    • Organizer
      The 48th American Society for Cell Biology Annual Meeting
    • Place of Presentation
      Moscone Center, San Francisco, U.S.A
    • Year and Date
      2008-12-16
    • Related Report
      2010 Final Research Report
  • [Presentation] SSX regulate cancer invasion via PARP-1, Histone H1 and MMP1 signaling2008

    • Author(s)
      Itoh, Kazuyuki
    • Organizer
      The 48th American Society for Cell Biology Annual Meeting
    • Place of Presentation
      San Francisco, U. S. A
    • Year and Date
      2008-12-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨・軟部腫瘍の肺転移に関与する分子SSXの機能解析2008

    • Author(s)
      吉岡潔子
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2008-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨・軟部腫瘍の肺転移に関与する分子SSXの機能解析2008

    • Author(s)
      吉岡潔子
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨・軟部腫瘍の肺転移に関与する分子SSXの機能解析2008

    • Author(s)
      吉岡潔子
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2008-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨・軟部腫瘍の肺転移に関与する分子SSXの機能解析2008

    • Author(s)
      吉岡潔子
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel highly metastatic synovial sarcoma cell line, Yamato-SS, is enriched cancer stem cells.2008

    • Author(s)
      Naka, Norifumi
    • Organizer
      Joint Metastasis Research Society-AACR Conference on Metastasis
    • Place of Presentation
      The Fairmont Hotel Vancouver, Vancouver, Canada
    • Year and Date
      2008-08-05
    • Related Report
      2010 Final Research Report
  • [Presentation] A novel highly metastatic synovial sarcoma cell line, Yamato -SS, is enriched cancer stem cells2008

    • Author(s)
      Naka, Norifumi
    • Organizer
      Joint Metastasis Research Society-AACR Conference on Metastasis
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2008-08-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] SSX-New Molecular target Regulating Cancer Invasion and Metastasis.2008

    • Author(s)
      Itoh, Kazuyuki
    • Organizer
      Joint Metastasis Research Society-AACR Conference on Metastasis
    • Place of Presentation
      The Fairmont Hotel Vancouver, Vancouver, Canada
    • Year and Date
      2008-08-04
    • Related Report
      2010 Final Research Report
  • [Presentation] SSX-New Molecular target Regulating Cancer Invasion and Metastasis2008

    • Author(s)
      Itoh, Kazuyuki
    • Organizer
      Joint Metastasis Research Society-AACR Conference on Metastasis
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2008-08-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨・軟部腫瘍の肺転移に関与する分子SSXの機能解析2008

    • Author(s)
      吉岡潔子
    • Organizer
      第17回日本がん転移学会総会
    • Place of Presentation
      鹿児島サンロイヤルホテル(鹿児島県)
    • Year and Date
      2008-07-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨・軟部腫瘍の肺転移に関与する分子SSXの機能解析2008

    • Author(s)
      吉岡潔子
    • Organizer
      第17回日本がん転移学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2008-07-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨・軟部腫瘍の転移に対する新規分子標的SSXの機能解析2008

    • Author(s)
      吉岡潔子
    • Organizer
      第41回整形外科学会 骨・軟部腫瘍学術集会
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Year and Date
      2008-07-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨・軟部腫瘍の転移に対する新規分子標的SSXの機能解析2008

    • Author(s)
      吉岡潔子
    • Organizer
      第41回整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.mc.pref.osaka.jp/omc2/biology.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.mc.pref.osaka.jp/omc2/biology.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.mc.pref.osakajp/omc2/biology.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.mc.pref.osaka.jp/omc2/biology.html

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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