| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
GSK3β is known to be involved in insulin/IGF signal and canonical Wnt signal, which play important roles in various kinds of biological processes. This study investigated the molecular mechanisms of regulation in bone and metabolism by GSK-3β. We performed the analyses of skeletal phenotype in GSK3β deficient mice under physiological or pathological conditions and functional analyses using mouse primary osteoblasts, chondrocytes, and various cell-lines. We elucidated the molecular network around GSK3β in osteoblast or chondrocyte differentiation.
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