| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Pathology of the osteoarthritis (OA) is uncovered. Gadd45β(growth arrest and DNA damaged inducible 45 beta) is a small protein (18kD) which is involved in cell cycle, apoptosis, stress, and hypertrophy. Since Gadd45β is characteristically expressed in clusters of early stage of OA, we hypothesized that Gadd45β is one of the key molecules in the process of OA. This study was designed to establish the conditional transgenic mice. The promoter of COMP was used in Tet-off system. DT mice was produced and the expression of Gadd45β was confirmed. C/EBPβ, the downstream of Gadd45β, DTmice was also produced and the gene expression was confirmed.
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