| Project/Area Number |
20591792
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
TANAKA Masami St.Marianna University School of Medicine, 医学(系)研究科(研究院), 准教授 (00171801)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Minoru 聖マリアンナ医科大学, 医学部, 助教 (10191800)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 軟骨 / 骨 / 軟骨代謝 / 骨代謝 / 石灰化 / 小人症 / モデル動物 / ラット |
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| Research Abstract |
Rats with spontaneous cartilage calcification insufficiency (CCI rat, mutant of the Sprague-Dawley strain) develop dwarfism accompanied by the shortness of all 4 limbs and the overall body length. CCI rats are characterized by systemic ossification deficiency of cartilage, and it was revealed that deficient endochondral ossification is present. The growth cartilage calcification was considered to be delayed in CCI rats. In the growth plate of the CCI rats, the expression level of FGF18 mRNA was markedly high, and resulting inhibits cartilage calcification. In the future, we intend to clarify the mechanism of cartilage calcification insufficiency in CCI rats, and use this animal to elucidate the mechanism of cartilage calcification.
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