| Project/Area Number |
20591798
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
|
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| Research Institution | Gifu University |
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Principal Investigator |
TANABE Kumiko Gifu University, 医学部附属病院, 講師 (30402209)
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| Co-Investigator(Kenkyū-buntansha) |
KOZAWA Osamu 岐阜大学, 医学系研究科, 教授 (90225417)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 中枢神経保護 / サイトカイン / Heat shock protein / アストロサイト / 細胞内情報伝達 / HSP27 / GDNF / ストレス蛋白質 |
|---|
| Research Abstract |
Heat shock protein 27 (HSP27), a low-molecular-weight HSP, is recognized as a molecular chaperone. In response to various stimuli, HSP27 expression is induced in the CNS. However, the exact roles of HSP27 in the CNS have not yet been clarified. We investigated the role of HSP27 in the IL-1β-induced IL-6 synthesis in C6 cells. In conclusion, it is suggested that phosphorylated status of HSP27 has a switching role in the IL-1β-induced IL-6 synthesis in C6 glioma cells.
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