• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Innovation of treatment for malignant hyperthermia and arrhythmia by inhibition of abnormal intracellular Ca2+ release through the ryanodine receptor

Research Project

Project/Area Number 20591805
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionYamaguchi University

Principal Investigator

KOBAYASHI Shigeki  Yamaguchi University, 医学部附属病院, 助教 (90397993)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Takeshi  山口大学, 大学院・医学系研究科, 助教 (50363122)
YANO Masafumi  山口大学, 医学部付属病院, 講師 (90294628)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords悪性高熱症 / 心室頻拍症 / 心不全 / ダントロレン / リアノジン受容体 / 不整脈
Research Abstract

Dantrolene, a specific drug for the treatment of malignant hyperthermia, was found to inhibit Ca^<2+> leak through not only the skeletal ryanodine receptor (RyR1), but also the cardiac ryanodine receptor (RyR2) by correcting the defective inter-domain interaction between N-terminal(1-619 amino acid) amd central (2000-2500 amino acid) domains of RyRs. Here, we examined 1)the effect of dantrolene on the Ca2+ release and cardiomyocyte function in chronic rapid pacing-induced heart failure dog model 2) the anti-arrhythmic effect of dantrolene in human CPVT-associated RyR2^<R2474S /+> knock-in (KI) mouse model. In heart failure model, dantrolene corrects defective inter-domain interactions within RyR2 in failing hearts, inhibits spontaneous Ca^<2+> leak, in turn improves cardiomyocyte function in failing hearts. In human CPVT-associated RyR2^<R2474S /+> knock-in (KI) mouse model, dantrolene prevents CPVT, presumably by correction of catecholamine-induced defective inter-domain interaction within RyR2inhibiting and inhibition of Ca^<2+> leak through RyR2. Thus, dantrolene may have a potential to treat heart failure and lethal arrhythmia, specifically targeting RyR2.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (56 results)

All 2011 2010 2009 2008 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (32 results) Remarks (1 results)

  • [Journal Article] Urinary8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure.2011

    • Author(s)
      Kobayashi S, Susa T, Tanaka T, Wada Y, Okuda S, Doi M, Nao T, Yoshiga Y, Yamada J, Okamura T, Ueyama T, Kawamura S, Yano M, Matsuzaki M.
    • Journal Title

      Eur J Heart Fail. 13

      Pages: 29-36

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure2011

    • Author(s)
      Shigeki Kobayashi
    • Journal Title

      Euro J Heart Fail

      Volume: 13 Pages: 29-36

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2 (R2474S/+) knock-in mouse model.2010

    • Author(s)
      Kobayashi S, Yano M, Uchinoumi H, Suetomi T, Susa T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Yamamoto T, Matsuzaki M.
    • Journal Title

      Cir J. 74

      Pages: 2579-2584

    • NAID

      10027424202

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure.2010

    • Author(s)
      Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.
    • Journal Title

      Cardiovasc Res. 87

      Pages: 609-617

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.2010

    • Author(s)
      Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M.
    • Journal Title

      Biochem Biophys Res Commun. 394

      Pages: 660-666

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.2010

    • Author(s)
      Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
    • Journal Title

      Cir Res. 81

      Pages: 1413-1423

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction2010

    • Author(s)
      Xiaojuan Xu
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 394 Pages: 660-666

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure2010

    • Author(s)
      Makoto Ono
    • Journal Title

      Cardiovasc Res

      Volume: 87 Pages: 609-617

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2R2474S/+ Knock-In Mouse Model2010

    • Author(s)
      Shigeki Kobayashi
    • Journal Title

      Circ J

      Volume: 74 Pages: 2579-2584

    • NAID

      10027424202

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor2010

    • Author(s)
      Hitoshi Uchinoumi
    • Journal Title

      Circ Res

      Volume: 106 Pages: 1413-1424

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor2010

    • Author(s)
      Hitoshi Uchinoumi
    • Journal Title

      Cir Res 81

      Pages: 1413-1423

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.2010

    • Author(s)
      Xu X
    • Journal Title

      Biochem Biophys Res Commun 394

      Pages: 660-666

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+release in heart failure.2010

    • Author(s)
      Makoto Ono
    • Journal Title

      Cardiovasc Res (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing inter-domain interactions within the ryanodine receptor.2009

    • Author(s)
      Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, IkemotoN, Matsuzaki M.
    • Journal Title

      J Am Coll Cardiol. 53

      Pages: 1993-2005

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of ryanodine receptor as a Ca(2+) regulatory center in normal and failing hearts.2009

    • Author(s)
      Yano M, Yamamoto T, Kobayashi S, Matsuzaki M.
    • Journal Title

      J Cardiol. 53

      Pages: 1-7

    • NAID

      10025182309

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.2009

    • Author(s)
      Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
    • Journal Title

      Cardiovasc Res. 81

      Pages: 536-545

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing inter-domain interactions within the rvanodine recentor2009

    • Author(s)
      Shigeki Kobayashi
    • Journal Title

      J Am Coll Cardiol 53

      Pages: 1993-2005

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+leak in failing hearts.2009

    • Author(s)
      Hiroki Tateishi
    • Journal Title

      Cardiovasc Res 81

      Pages: 536-545

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of ryanodine receptor as a Ca(2+)regulatory center in normal and failing hearts.2009

    • Author(s)
      Masafumi Yano
    • Journal Title

      J Cardiol 53

      Pages: 1-7

    • NAID

      10025182309

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing inter-domain interactions within the ryanodine receptor.2009

    • Author(s)
      Shigeki Kobayashi
    • Journal Title

      J Am Coll Cardiol 53

      Pages: 1993-2005

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective Ca2+ cycling as a key pathogenic mechanism of heart failure.2008

    • Author(s)
      Yano M, Yamamoto T, Kobayashi S, Ikeda Y, Matsuzaki M.
    • Journal Title

      Circ J. 72

      Pages: 22-30

    • NAID

      110006935628

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.2008

    • Author(s)
      Yamamoto T, Yano M, Xu X, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Kobayashi S, Ikemoto N, Matsuzaki M.
    • Journal Title

      Circulation. 117

      Pages: 762-772

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts2008

    • Author(s)
      Takeshi Yamamoto
    • Journal Title

      Circulation 117

      Pages: 762-772

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Novel Inter-domain Interaction Within RyR2 as a Common Therapeutic Target by Channel Stabilization in Heart Failure and in Heart Failure and Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT).2010

    • Author(s)
      Masafumi Yano, Masakazu Fukuda, Akihiro Hino, Takeshi Suetomi, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Masunori Matsuzaki.
    • Organizer
      83rd Scientific Session of American Heart Association.
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2010-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Masunori Matsuzaki Urinary 8-Hydroxy-2'-Deoxyguanosine is a Biomarker for Evaluating the Inflammatory Activity and the Effectiveness to Corticosteroids in Patients with Cardiac Sarcoidosis.2010

    • Author(s)
      Takeo Tanaka, Shigeki Kobayashi, Takehisa Susa, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Jutaro Yamada, Takeshi Ueyama, Takayuki Okamura, Shuji Kawamura, Masafumi Yano
    • Organizer
      83rd Scientific Session of American Heart Association.
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2010-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Increased Affinity of Calmodulin Binding to Cardiac Ryanodine Receptor Corrects the Defective Channel Gating in Failing Hearts.2010

    • Author(s)
      Akihiro Hino, Masafumi Yano, Masakazu Fukuda, Takeshi Suetomi, Makoto Ono, Xiaojuan Xu, Hitoshi Uchinoumi, Takehisa Susa, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki.
    • Organizer
      83rd Scientific Session of American Heart Association.
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2010-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Correction of Defective Calmodulin Binding to Cardiac Ryanodine Receptor Inhibits Aberrant Ca2+ Release in CPVT-associated Mutation.2010

    • Author(s)
      Masakazu Fukuda, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Xiaojuan Xu, Makoto Ono, Hitoshi Uchinoumi, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki.
    • Organizer
      83rd Scientific Session of American Heart Association.
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2010-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Mutation-linked Defective Domain Interaction within the Ryanodine Receptor Causes Ca2+ Leak Leading to Catecholaminergic Polymorphic Ventricular Tachycardia.2010

    • Author(s)
      Takeshi Suetomi, Masafumi Yano, Masakazu Fukuda, Akihiro Hino, Makoto Ono, Xiaojuan Xu, Takehisa Susa, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Masunori Matsuzaki.
    • Organizer
      83rd Scientific Session of American Heart Association.
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2010-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Novel Inter-domain Interaction Within RyR2 as a Common Therapeutic Target by Channel Stabilization in Heart Failure and Catecholaminergic Polymorphic Ventricular Tachvcardia(CAVT)2010

    • Author(s)
      Masafumi Yano
    • Organizer
      83rd Scientific Session of American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Urinary 8-Hydroxy-2'-Deoxyguanosine is a Biomarker for Evaluating the Inflammatory Activity and the Effectiveness to Corticosteroids in Patients with Cardiac Sarcoidosis2010

    • Author(s)
      Takeo Tanaka
    • Organizer
      83rd Scientific Session of American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Increased Affinity of Calmodulin Binding to Cardiac Ryanodine Receptor Corrects the Defective Channel Gating in Failing Hearts2010

    • Author(s)
      Akihiro Hino
    • Organizer
      83rd Scientific Session of American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Correction of Defective Calmodulin Binding to Cardiac Ryanodine Receptor Inhibits Aberrant Ca2+ Release in CPVT-associated Mutation2010

    • Author(s)
      Masakazu Fukuda
    • Organizer
      83rd Scientific Session of American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mutation-linked Defective Domain Interaction within the Ryanodine Receptor Causes Ca2+ Leak Leading to Catecholaminergic Polymorphic Ventricular Tachycardia2010

    • Author(s)
      Takeshi Suetomi
    • Organizer
      83rd Scientific Session of American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Risk Stratification of Chronic Heart Failure by the Combination of Urinary 8-Hydroxy-2'-Deoxyguanosine and Plasma Brain Natriuretic Peptide.2010

    • Author(s)
      Takehisa Susa, Shigeki Kobayashi, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Jutaro Yamada, Takayuki Okamura, Takeshi Ueyama, Masafumi Yano, Masunori Matsuzaki.
    • Organizer
      The 14th Annual Scientific Meeting of the Japanese Heart Failure Society.
    • Place of Presentation
      東京 京王プラザホテル
    • Year and Date
      2010-10-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Mechanism of Destabilized RyR2 Channel in Catecholaminergic Polymorphic Ventricular Tachycardia.2010

    • Author(s)
      Takeshi Suetomi, Masafumi Yano, Makoto Ohno, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Masahiro Doi, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Masunori Matsuzaki.
    • Organizer
      The 14th Annual Scientific Meeting of the Japanese Heart Failure Society.
    • Place of Presentation
      東京 京王プラザホテル
    • Year and Date
      2010-10-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Mechanism of Destabilized RyR2 Channel in Catecholaminergic Polymorphic Ventricular Tachycardia2010

    • Author(s)
      Takeshi Suetomi
    • Organizer
      The 14th Annual Scientific Meeting of the Japanese Heart Failure Society
    • Place of Presentation
      東京
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Risk Stratification of Chronic Heart Failure by the Combination of Urinary 8-Hydroxy-2'-Deoxyguanosine and Plasma Brain Natriuretic Peptide2010

    • Author(s)
      Takehisa Susa
    • Organizer
      The 14th Annual Scientific Meeting of the Japanese Heart Failure Society
    • Place of Presentation
      東京
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Correction of the defective inter-domain interaction within ryanodine receptor prevents the development of heart failure.2010

    • Author(s)
      Hitoshi Uchinoumi, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Xiaojuan Xu, Makoto Ohno, Shinichi Okuda, MasahiroDoi, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki.
    • Organizer
      20th World Congress of the International Society for Heart Research.
    • Place of Presentation
      京都,京都国際会議場
    • Year and Date
      2010-05-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Urine 8-hydroxy-2'-deoxyguanosine is a marker for predicting mortality and morbidity as swell as evaluating the effectiveness of beta-blocker therapy in patients with chronic heart failure.2010

    • Author(s)
      Susa Takehisa
    • Organizer
      ACC. 10 and i2 Summit
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Urine 8-hydroxy-2'-deoxyguanosine is a Marker for Predicting Mortality and Morbidity as well as Evaluating the Effectiveness of Beta-blocker Therapy in Patients with Chronic Heart Failure.2010

    • Author(s)
      Takehisa Susa, Shigeki Kobayashi, Takeo Tanaka, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Jutaro Yamada, Takeshi Ueyama, Shuji Kawamura, Masafumi Yano, Masunori Matsuzaki.
    • Organizer
      59th Annual Scientific Session of the American College of Cardiology.
    • Place of Presentation
      Atlanta, USA.
    • Year and Date
      2010-03-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Decreased Affinity of Calmodulin to the Cardiac Ryanodine Receptor Plays a Crucial Role in the CPVT-type Channel Disorder.2010

    • Author(s)
      Xiaojuan Xu, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Makoto Ohno, Hitoshi Uchinoumi, Tetsuro Oda, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Tomoko Ohkusa, Masunori Matsuzaki.
    • Organizer
      74th Annual Scientific Meeting of the Japanese Circulation Society.
    • Place of Presentation
      京都,京都国際会議場
    • Year and Date
      2010-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Correction of Defective Conformational Regulation of the Cardiac Ryanodine Receptor is a New Therapeutic Strategy against Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT).2010

    • Author(s)
      Hitoshi Uchinoumi, Masafumi Yano, Takeshi Suetomi, Makoto Ohno, Xiaojuan Xu, Hiroki Tateishi, Tetsuro Oda, Shinichi Okuda, Masahiro Doi, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Tomoko Ohkusa, Masunori Matsuzaki.
    • Organizer
      The 74th Annual Scientific Meeting of the Japanese Circulation Society.
    • Place of Presentation
      京都,京都国際会議場
    • Year and Date
      2010-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Interruption of Novel Inter-domain Interaction within RyR2 as a Common Therapeutic Target for Channel Stabilization in Heart Failure and CPVT.2010

    • Author(s)
      Takeshi Yamamoto, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Makoto Ohno, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Masahiro Doi, Shigeki Kobayashi, Masunori Matsuzaki.
    • Organizer
      The 74th Annual Scientific Meeting of the Japanese Circulation Society.
    • Place of Presentation
      京都,京都国際会議場
    • Year and Date
      2010-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Urinary 8-Hydroxy-2'Deoxyguanosine as an Oxidative Stress Biomarker in Patients with Chronic Heart Failure.2010

    • Author(s)
      Shigeki Kobayashi, Takehisa Susa, Takeo Tanaka, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Yasuhiro Yoshiga, Jutaro Yamada, Takeshi Ueyama, Shuji Kawamura, Masafumi Yano, Masunori Matsuzaki.
    • Organizer
      The 74th Annual Scientific Meeting of the Japanese Circulation Society.
    • Place of Presentation
      京都,京都国際会議場
    • Year and Date
      2010-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Correction of defective inter-domain interaction within the cardiac ryanodine receptor as a new therapeutic strategy against catecholaminergic polymorphic ventricular tachycardia (CPVT).2009

    • Author(s)
      Hitoshi Uchinoumi, Masafumi Yano, Takeshi Suetomi, Makoto Ohno, Xiaojuan Xu, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki.
    • Place of Presentation
      札幌,ロイトン札幌
    • Year and Date
      2009-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Low-dose of β Blocker Improves Cardiac Function in Patients With Acute Heart Failure Partly by Inhibiting Ca2+ Leak Through the Ryanodine Receptor.2009

    • Author(s)
      Shigeki Kobayashi, Takeo Tanaka, Takehisa Susa, Makoto Ohno, Hitoshi Uchinoumi, Shinichi Okuda, Masahiro Doi, Shuji Kawamura, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki.
    • Organizer
      82nd Scientific Session of American Heart Association.
    • Place of Presentation
      Orlando, USA.
    • Year and Date
      2009-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Decreased Affinity of Calmodulin to RyR2 May Be a Sauce Mechanism of Leaky Channel in CPVT-associated Mutation.2009

    • Author(s)
      Xiaojuan Xu, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Makoto Ohno, Hitoshi Uchinoumi, Tetsuro Oda, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Tomoko Ohkusa, Masunori Matsuzaki.
    • Organizer
      82nd Scientific Session of American Heart Association.
    • Place of Presentation
      Orlando, USA.
    • Year and Date
      2009-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Mutation-linked Channel Disorder in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is Caused by Abnormally Tight Domain-Domain Interaction in RyR2.2009

    • Author(s)
      Takeshi Suetomi, Masafumi Yano, Akihiro Hino, Makoto Ohno, Xiaojuan Xu, Takehisa Susa, Hitoshi Uchinoumi, Tetsuro Oda, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki.
    • Organizer
      82nd Scientific Session of American Heart Association.
    • Place of Presentation
      Orlando, USA.
    • Year and Date
      2009-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Correction of Defective Inter-domain Interaction Within the Cardiac Ryanodine Receptor as a New Therapeutic Strategy Against Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT).2009

    • Author(s)
      Hitoshi Uchinoumi, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Makoto Ohno, Xiaojuan Xu, Tetsuro Oda, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Masunori Matsuzaki.
    • Organizer
      82nd Scientific Session of American Heart Association.
    • Place of Presentation
      Orlando, USA.
    • Year and Date
      2009-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Urine 8-hydroxy-2'-deoxyguanosine is Well Correlated With Cardiac Dysfunction and Poor Prognosis in Chronic Heart Failure Patients.2009

    • Author(s)
      Takehisa Susa, Shigeki Kobayashi, Takeo Tanaka, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Yomoko Nao, Yasuhiro Yoshiga, Jutaro Yamada, Shuji Kawamura, Masafumi Yano, Masunori Matsuzaki.
    • Organizer
      82nd Scientific Session of American Heart Association.
    • Place of Presentation
      Orlando, USA.
    • Year and Date
      2009-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Urine 8-hydroxy-2'-deoxyguanosine as a New Biomarker of Inflammatory Activity in Patients With Cardiac Sarcoidosis.2009

    • Author(s)
      Takeo Tanaka, Shigeki Kobayashi, Takehisa Susa, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Tomoko Nao, Yasuhiro Yoshiga, Jutaro Yamada, Shuji Kawamura, Masafumi Yano, Masunori Matsuzaki.
    • Organizer
      82nd Scientific Session of American Heart Association.
    • Place of Presentation
      Orlando, USA.
    • Year and Date
      2009-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Low-dose of β blocker improves cardiac function in patients with acute heart failure partly by inhibiting Ca2+leak through ryanodine receptor.2009

    • Author(s)
      Shigeki Kobayashi
    • Organizer
      Scientific Sessions 2009 of American Heart Association
    • Place of Presentation
      Orland, USA
    • Year and Date
      2009-11-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Low-dose βblocker therapy improves cardiac function in patients with acute heart failure partly through correction of abnormal intracellular Ca2+ handling2009

    • Author(s)
      Shigeki Kobayashi
    • Organizer
      The American College of Cardiology 58^<th> Annual Scientific Session
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dantrolene Prevents Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)by Correcting Abnormal Ca^<2+>Release through the Ryanodine Receptor2009

    • Author(s)
      Shigeki Kobayashi
    • Organizer
      The 73nd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dantrolene inhibits spontaneous Ca^<2+> release as a substrate for catecholaminergic polymorphic ventricular tachycardia (CPVT)by correcting defective inter-domain interaction within the ryanodine receptor2008

    • Author(s)
      Shigeki Kobayashi
    • Organizer
      Scientific Sessions 2008 of American Heart Association
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等 なし

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi