| Project/Area Number |
20591808
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
|
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| Research Institution | Oita University |
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Principal Investigator |
SHINGU Chihiro Oita University, 医学部, 講師 (30295191)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Shigekiyo 大分大学, 医学部, 講師 (90274761)
YOKOI Isao 大分大学, 医学部, 教授 (80150366)
NOGUCHI Takayuki 大分大学, 医学部, 教授 (90156183)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 全脳虚血 / フリーラジカル / 電子スピン共鳴 / 脳低体温療法 |
|---|
| Research Abstract |
We focused on the free radicals which play an important role in brain cell damage especially in ischemia-reperfusion injury, and demonstrated that some antioxidants which can scavenge the free radicals had neuroprotective efficacy. In addition, we tried to observe the free radical dynamics with ESR device. On the other hand, therapeutic hypothermia is one of the worldwide medical treatments for protecting brain tissues in brain injury and cardiac surgery with heart-lung machine. We established the animal model of the hypothermia, which can be helpful for study using therapeutic hypothermia.
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