The effect of the single nucleotide polymorphism on the changing of hemodynamics during general anesthesia

• Project/Area Number: 20591815
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Wakayama Medical University
• Principal Investigator: KIMOTO Yoshiki 和歌山県立医科大学, 医学部, 講師 (20316110)
• Co-Investigator(Kenkyū-buntansha): 畑埜 義雄 和歌山県立医科大学, 医学部, 教授 (70115913)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 遺伝子多型 / 血圧 / 麻酔薬 / 血圧変動 / Rho / 麻酔 / 予測 / Rho kinase / Rhoキナーゼ

Research Abstract

It is well known that single nucleotide polymorphism(SNP) in rock gene "one of the causes genes of hypertension" induced the significant increase in blood pressure. We studied the frequency of rock2 gene SNP(rs9808232), the effects of this gene on the blood pressure and the hemodynamic effects of this gene during anesthetic induction in Japanese population.

Research Products

• [Journal Article] 帝王切開術中の薬剤性冠動脈攣縮を予期できるか?～遺伝子一塩基多型による検討～ (2012)
  • Author(s): 川嶋浩平、中畑克俊、木本吉紀、南佐和子、井箟一彦、西川光一
  • Journal Title: 分娩と麻酔 Volume: (in print)
  • Peer Reviewed
• [Journal Article] Reduction of adhesion formation by an angiotensin type 1 receptor antagonis (2011)
  • Author(s): Tokinaga Y, Kimoto Y, Ogawa K, Mizumoto K, Tange K, Hatano Y
  • Journal Title: Langenbecks Arch Surg Volume: 396 Pages: 127-132
  • Peer Reviewed
• [Journal Article] Reduction of adhesion formation by an angiotensin type 1 receptor antagonist. (2011)
  • Author(s): Tokinaga Y, Kimoto Y, Ogawa K, Mizumoto K, Tange K, Hatano Y.
  • Journal Title: Langenbecks Arch Surg.Epub 2010 Jul 1 396(1) Pages: 127-132
  • Peer Reviewed
• [Journal Article] Reduction of adhesion formation by an angiotensin type 1 receptor antagonist. (2011)
  • Author(s): Tokinaga Y, Kimoto Y, Ogawa K, Hatano Y
  • Journal Title: Langenbecks Arch Surg Volume: 396(1) Pages: 127-32
  • Peer Reviewed
• [Journal Article] Reduction of adhesion formation by an angiotensin type 1 receptor antagonist (2010)
  • Author(s): Tokinaga Y, Kimoto Y, Ogawa K, Mizumoto K, Tange K, Hatano Y
  • Journal Title: Langenbecks Arch Surg Volume: 396(1) Pages: 127-32
  • Peer Reviewed
• [Journal Article] Differential vasodilation response to olprinone in rabbit renal and common carotid arteries (2010)
  • Author(s): Minonishi T, Ogawa K, Tokinaga Y, Negoro T, Kimoto Y, Hatano Y
  • Journal Title: J Anesth Volume: 24(1) Pages: 61-6
  • NAID: 10027265635
  • Peer Reviewed
• [Journal Article] Differential vasodilation response to olprinone in rabbit renal and common carotid arteries. (2010)
  • Author(s): Minonishi T, Ogawa K, Tokinaga Y, Negoro T, Kimoto Y, Hatano Y.
  • Journal Title: J Anesth. 24(1) Pages: 61-66
  • NAID: 10027265635
  • Peer Reviewed
• [Journal Article] Differential vasodilation response to olprinone in rabbit renal and common carotid arteries. (2010)
  • Author(s): Minonishi T, Ogawa K, Tokinaga Y, Negoro T, Kimoto Y, Hatano Y.
  • Journal Title: J Anesth.
  • NAID: 10027265635
  • Peer Reviewed
• [Presentation] 舌神経損傷に対する神経再建術中における術中の体温変化について (2011)
  • Author(s): 木本吉紀、黒崎弘倫、江尻加名子、吉田朱里、小川幸志
  • Organizer: 日本臨床麻酔科学会第31回大会
  • Place of Presentation: 沖縄県宜野湾市
  • Year and Date: 2011-11-03
• [Presentation] 舌神経損傷に対する神経再建術における術中の体温変化について (2011)
  • Author(s): 木本吉紀, 黒崎弘倫, 小川幸志, 他
  • Organizer: 日本臨床麻酔学会第31大会
  • Place of Presentation: 沖縄県宜野湾市
  • Year and Date: 2011-11-03
• [Presentation] 高血圧関連因子Rho kinase遺伝子における1塩基多型の日本人における検討 (2010)
  • Author(s): 木本吉紀、時永泰行、黒崎弘倫、中田亮子、小川幸志、畑埜義雄
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2010-06-04
• [Presentation] 高血圧関連因子Rho kinase遺伝子における1塩基多型の日本人における検討 (2010)
  • Author(s): 木本吉紀, 時永泰行, 黒崎弘倫, 中田亮子, 小川幸志, 畑埜義雄
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-04
• [Presentation] 高血圧関連因子Rho kinase遺伝子における1塩基多型の日本人における検討 (2010)
  • Author(s): 木本吉紀
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡 日本
  • Year and Date: 2010-06-04
• [Presentation] シンバスタチンは糖尿病における内皮依存性弛緩反応低下を回復させる (2009)
  • Author(s): 時永泰行、小川幸志、木本吉紀、槙野仁奈、阪中容、畑埜義雄
  • Organizer: 日本麻酔科学会第56回学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 2009-08-16
• [Presentation] イレウス緊急手術患者の麻酔導入時におけるレミフェンタニル併用の急速導入時の血行動態へのケタミンの影響 (2008)
  • Author(s): 木本吉紀、箕西利之、角谷哲也、小松仁奈、根来孝明
  • Organizer: 日本麻酔科学会第55回学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-06-13
• [Presentation] イレウス緊急手術患者の麻酔導入時におけるレミフェンタニル併用の急速導入時の血行動態へのケタミンの影響 (2008)
  • Author(s): 木本吉紀, 箕西利之, 角谷哲也, 小松仁奈, 根来孝明
  • Organizer: 日本麻酔科学会第55回学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-13
• [Presentation] イレウス緊急手術患者の麻酔導入時におけるレミフェンタニル併用の急速導入時の血行動態へのケタミンの影響 (2008)
  • Author(s): 木本吉紀
  • Organizer: 日本麻酔科学会第55回学術会議
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-13