The elucidation of the intracerebral transporter control to lead the new cerebroprotection method
| Project/Area Number |
20591818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
MUROZONO Michihiro Tokyo Medical University, 医学部, 講師 (70276947)
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| Co-Investigator(Kenkyū-buntansha) |
岡田 真也 東京医科大学, 医学部, 講師 (20297279)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脳虚血 / mdr1a / 血液脳関門 / P-glycoprotein / サイトカイン / P-glucoprotein / ノックアウトマウス |
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| Research Abstract |
There is mdr1a intracranially, which blocks invasion of multi drug to brain. Mdr1 also influences displacement of endogenous substance. We made a focal cerebral ischemia model using mdr1a knockout mouse and measured blood cytokine and apoptosis-related substances such as Bcl-2 in brain. From the results, we suggest that mdr1a influences IL-6, Bcl-2 and Bax after cerebral ischemia and promotes the damage to brain.
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Report
(4 results)
Research Products
(13 results)
