| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
The effects of general anesthetics on the changes of internal gene expression, protein expression and metabolites were evaluated by genomics, proteomics, and metabolomics. The main results are as follows. (1) The general anesthetics affects the clock gene expression in the brain and influences circadian rhythm. (2) The inhalational anesthetic influences the change of protein expression in the brain more than intravenous anesthetic. (3) The intravenous anesthetic influences the brain metabolism more than inhalational anesthetic. These results suggested the need of the further molecular biologic examination according to the each biological system.
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