Ischemic postconditioning by electric or magnetic stimulation against the reperfusion injury after cerebral or spinal ischemia

• Project/Area Number: 20591821
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kurume University
• Principal Investigator: HARADA Hideki Kurume University, 医学部, 講師 (30198923)
• Co-Investigator(Kenkyū-buntansha): MISHIMA Yasunori 久留米大学, 医学部, 講師 (30258470) ; NIIYAMA Shuhei 久留米大学, 医学部, 講師 (40258455) ; 原 将人 久留米大学, 医学部, 助教 (10330862)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ポストコンディショニング / 脳脊髄虚血再灌流傷害 / 電磁気刺激

Research Abstract

We explored the postconditioning induced by transcranial electric stimulation in the early phase of reperfusion after transient focal cerebral ischemia. Event though, we used the condition of electrical stimulation to enable to induce the protective cytokine or MAPK, there is not protective effects of postconditioning nor any influence for the results of rapid preconditioning induced by electrical stimulation.

Research Products

• [Journal Article] Astrocytic P2Y_1 receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia. (2011)
  • Author(s): Kuboyama K, Harada H, (2番目)
  • Journal Title: Journal of Cerebral Blood Flow and Metabolism Volume: In press
  • Peer Reviewed
• [Journal Article] Cerebrospinal Fluid following Cerebral Ischemia Accelerates the Proliferation of Bone Marrow Stromal Cells in vitro. (2010)
  • Author(s): Orito K, Harada H
  • Journal Title: The Kurume Medical Journal 57 Pages: 21-28
  • NAID: 130000441577
  • Peer Reviewed
• [Journal Article] 総説:ポストコンディショニングによる脳保護の可能性 -心筋虚血から脳虚血への展開- (2010)
  • Author(s): 原田秀樹
  • Journal Title: 臨床麻酔 34 Pages: 1253-1257
• [Journal Article] 側彎症手術における術中脊髄モニタリング 脊椎・脊髄の解剖学的偏位と術中モニタリング波形の変化 (2010)
  • Author(s): 脇田瞳,原田秀樹
  • Journal Title: 脊髄機能診断学 31 Pages: 110-117
  • Peer Reviewed
• [Journal Article] Cerebrospinal Fluid following Cerebral Ischemia Accelerates the Proliferation of Bone Marrow Stromal Cells in vitro. (2010)
  • Author(s): Orito K, Harada H(2番目)
  • Journal Title: Kurume Medical Journal Volume: 57 Pages: 21-28
  • NAID: 130000441577
  • Peer Reviewed
• [Journal Article] ポストコンディショニングによる脳保護の可能性-心筋虚血から脳虚血への展開- (2010)
  • Author(s): 原田秀樹 (1番目、3人中)
  • Journal Title: 臨床麻酔 Volume: 34 Pages: 1253-1257
• [Journal Article] 術中脊髄モニタリングにおけるtrue positive例の神経学的予後と術中対応策の考察 (2009)
  • Author(s): 山田圭,原田秀樹
  • Journal Title: 西日本脊椎研究会誌 35 Pages: 39-45
  • Peer Reviewed
• [Journal Article] 術中脊髄モニタリングで警告発信を行う基準の検討CMAPによるモニタリングの問題点を含めて (2008)
  • Author(s): 山田圭,原田秀樹
  • Journal Title: 西日本脊椎研究会誌 34 Pages: 139-144
  • Peer Reviewed
• [Journal Article] 特発性側彎症における術中脊髄モニタリング矯正操作後のMEPsの波形の変化についての考察 (2008)
  • Author(s): 山田圭,原田秀樹
  • Journal Title: 脊髄機能診断学 29 Pages: 127-132
  • Peer Reviewed
• [Journal Article] Astrocytic P2Y_1 receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia.
  • Author(s): Kuboyama K, Harada H
  • Journal Title: JCBFM (in press)
  • Peer Reviewed
• [Presentation] Bilateral bispectral index monitoring during experimental surgery for the middle cerebral artery occlusion in rats (2010)
  • Author(s): Gotannda Y, Harada H
  • Organizer: 40th Annual Meeting Neuroscience
  • Place of Presentation: サンディエゴ
• [Presentation] 側彎症手術における術中脊髄モニタリング～術前の脊椎・脊髄解剖学的評価と術中誘発電位変化との関連性～ (2010)
  • Author(s): 津田勝哉,原田秀樹
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡
• [Presentation] Propofol Prevents Anandamide-Induced Apoptosis Via Non-Connabinoid Receptor-Mediated Mechanism (2009)
  • Author(s): Kameyama N, Harada H
  • Organizer: ASA Annual Meeting
  • Place of Presentation: ニューオリンズ
• [Presentation] Propofol Prevents Anandamide-Induced Cell Death in Endotherial Cells (2009)
  • Author(s): Itoh T, Harada H
  • Organizer: ASA Annual Meeting
  • Place of Presentation: サンディエゴ
• [Presentation] 脳虚血後脳脊髄液は骨髄間葉系幹細胞の増殖を加速する (2009)
  • Author(s): 原田秀樹
  • Organizer: 第13回日本神経麻酔・集中治療研究会
  • Place of Presentation: 大阪
• [Presentation] Cerebrospinal fluid after transient cerebral ischemia supports viability and proliferation of born marrow stromal cells in vitro for regenerative medicine (2008)
  • Author(s): Harada H, et al.
  • Organizer: Neuroscience 2008
  • Place of Presentation: Washington DC, USA.
  • Year and Date: 2008-11-17
• [Presentation] Role of adrenoceptors in the regulation of DARPP-32 phosphorylation in neostriatal neurons (2008)
  • Author(s): Hara M
  • Organizer: Neuroscience 2008
  • Place of Presentation: ワシントン
• [Presentation] Cerebrospinal fluid after transient cerebral ischemia supports viability and proliferation of born marrow stromal cells in vitro for regenerative medicine (2008)
  • Author(s): 原田秀樹
  • Organizer: Neuroscience 2008
  • Place of Presentation: ワシントン
• [Patent(Industrial Property Rights)] 実験動物用脳波電極 (2010)
  • Inventor(s): 原田秀樹
  • Industrial Property Rights Holder: 久留米大学
  • Industrial Property Number: 2010-174737
  • Filing Date: 2010-09-03
• [Patent(Industrial Property Rights)] 脳内血流測定デバイス (2010)
  • Inventor(s): 原田秀樹
  • Industrial Property Rights Holder: 久留米大学
  • Acquisition Date: 2010-04-16