Pharmacologic plasticity of analgesic drugs in neuropathic pain states-measurement with monoamines in the spinal cord-
| Project/Area Number |
20591823
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gunma University |
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Principal Investigator |
OBATA Hideaki Gunma University, 医学部, 講師 (20302482)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ノルアドレナリン / セロトニン / マイクロダイアライシス / 神経障害性疼痛 / 脊髄 / ラット / ノルアドレナリソ |
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| Research Abstract |
We examined mechanisms of antinociceptive effects of drugs such as antidepressant and gabapentin for neuropathic pain using rat pain models. We also measured spinal noradrenalin and serotonin level after the drug injection using microdialysis. We demonstrated that these drugs increased noradrenalin level in the spinal cord and the noradrenalin increase strongly contributed to the inhibitory effect for neuropathic pain.
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Report
(4 results)
Research Products
(50 results)
