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The role of sex steroids during cardio-pulmonary resuscitation-the study of a transient total cerebral ischemia model in rabbit

Research Project

Project/Area Number 20591824
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionGifu University

Principal Investigator

IIDA Mami  Gifu University, 医学系研究科, 非常勤講師 (80350859)

Co-Investigator(Kenkyū-buntansha) IIDA Hiroki  岐阜大学, 医学系研究科, 教授 (30159561)
土肥 修司  岐阜大学, 大学院・医学系研究科, 教授 (80136952)
土肥 修司  岐阜大学, 大学院・医学系研究科, 教授 (40155627)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords心肺蘇生 / 脳保護 / 性ホルモン / エストロジェン / 脳血管 / 血管内皮機能 / ラビット
Research Abstract

There are very few effective neuroprotective drugs during and after cerebral ischemia in spite of many studies for last two decades. We focused on gender differences and sex steroid for protection and restoration of neuronal survival and functional outcome. Our purpose of this study is to evaluate whether bolus or short term sex steroid application after transient total cerebral ischemia has a protective effect for cerebral vascular response in rabbits using with a pial window preparation.
In male or female anesthetized Japanese white rabbits, we applied ACh (10^<-6>M and 10^<-5>M, endothelium dependent vasodilator) topically to pial vessels, before and 1 hour after a 5-min intervention consisting of cerebral ischemia produced by inflation of a neck tourniquet with or without posttreatment of bolus intravenous 17β-estradiol. Although we tried to have stable maneuver, but unfortunately there are no clear results about the cerebrovascular- and neuroprotective effect of 17β-estradiol. Thus, for the current year we simultaneously examined the effect of 17β-estradiol for spinal protection during spinal ischemia which technique is established.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (39 results)

All 2010 2009 2008 Other

All Journal Article (30 results) (of which Peer Reviewed: 30 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] 起床困難 いきなり名医!見わけが肝心、不定愁訴-訴えの見極め方と治療の極意2010

    • Author(s)
      飯田真美
    • Journal Title

      jmedmook(森田浩之(編))(日本医事新報社) 第9号

      Pages: 142-146

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 動悸いきなり名医!見わけが肝心、不定愁訴-訴えの見極め方と治療の極意2010

    • Author(s)
      飯田真美
    • Journal Title

      jmedmook(森田浩之(編))(日本医事新報社) 第9号

      Pages: 115-119

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] III疾患編B.生活習慣病喫煙日常診療に使えるガイドライン特集-より良い診療を目指してー2010

    • Author(s)
      飯田真美, 藤原久義
    • Journal Title

      綜合臨床 53巻増刊

      Pages: 832-837

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of tumor necrosis factor-alpha-induced interleukin-6 synthesis in glioma cells.2010

    • Author(s)
      Tanabe K, Matsushima-Nishiwaki R, Yamaguchi S, Iida H, Dohi S, Kozawa O.
    • Journal Title

      J Neuroinflammation. 6

      Pages: 7-16

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary study of the efficacy of radiofrequency lesions of stellate ganglion in chronic pain patients.2010

    • Author(s)
      Yamaguchi S, Iida H, Sumi K, Takenaka M, Yoshimura N, Dohi S.
    • Journal Title

      Pain Med. 11

      Pages: 142-144

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative effects of cilostazol and aspirin on the Impairment of endothelium-dependent cerebral vasodilation caused by acute cigarette smoking in rats.2010

    • Author(s)
      Iida H, Iida M, Takenaka M, Fukuoka N, Dohi S.
    • Journal Title

      J Thromb Thrombolysis 29

      Pages: 483-488

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative effects of cilostazol and aspirin on the impairment of endothelium-dependent cerebral vasodilation caused by acute cigarette smoking in rats2010

    • Author(s)
      Iida, H, et al.
    • Journal Title

      J Thromb Thrombolysis

      Volume: 29 Pages: 483-488

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of tumor necrosis factor-alpha-induced interleukin-6 synthes is in glioma cells2010

    • Author(s)
      Tanabe, K, et al.
    • Journal Title

      J Neuroinflammation

      Volume: 16 Pages: 16-16

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary study of the efficacy of radiofrequency lesions of stellate ganglion in chronic pain patients2010

    • Author(s)
      Yamaguchi, S, et al.
    • Journal Title

      Pain Med

      Volume: 11 Pages: 142-144

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative effects of cilostazol and aspirin on the impairment of endothelium-dependent vasodilation caused by acute cigarette smoking in rats.2010

    • Author(s)
      Iida H, Iida M, et al.
    • Journal Title

      J Thromb Thrombolysis 29

      Pages: 483-488

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] インピーダンス脈波を利用した血管内皮機能測定健常者と糖尿病患者の阻血後反応性充血の比較2009

    • Author(s)
      近藤正之, 横田康成, 飯田真美, 飯田宏樹, 森田浩之, 宇野嘉弘
    • Journal Title

      電子情報通信学会技術研究報告(MEとバイオサイバネティックス) 109

      Pages: 57-62

    • NAID

      110007333540

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative effects of ultra-short-acting beta1-blockers on voltage-gated terodotoxin-resisitant Na+ channels in rat sensory neurons.2009

    • Author(s)
      Tanahashi S, Iida H, et al.
    • Journal Title

      Eur J Anaesth 26

      Pages: 196-200

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association between the initial end-tidal carbon dioxide difference and the lowest arterial oxygen tension value obtained during one-lung anesthesia with propofol or sevoflurane.2009

    • Author(s)
      Fukuoka N, Iida H, et al.
    • Journal Title

      J Cardiothorac Vasc Anesth 23

      Pages: 775-779

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative smoking cessation and smoke-free policy in a university hospital in Japan.2008

    • Author(s)
      Iida H, Iida M, Dohi S, Fukuoka N, Iida M
    • Journal Title

      Can J Anesth 55

      Pages: 316-318

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of transient cerebral ischemia on vasopressin-induced vasoconstriction in rabbit cerebral vessels.2008

    • Author(s)
      Kumazawa M, Iida H, Uchida M, Iida M, Takenaka M, Fukuoka N, Michino T, Dohi S.
    • Journal Title

      Anesth Analg. 106

      Pages: 910-915

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase inhibitor and nicotinamide adenine dinucleotide phosphate oxidase inhibitor prevent impairment of endothelium-dependent cerebral vasodilation by acute cigarette smoking in rats.2008

    • Author(s)
      Iida H, Iida M, Takenaka M, Fukuoka N, Dohi S.
    • Journal Title

      J Renin-Angiotensin-Aldosterone System. 9

      Pages: 89-94

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of spinal analgesics on spinal circulation. The safety standpoint.2008

    • Author(s)
      飯田宏樹, 飯田真美
    • Journal Title

      J Neurosurg Anesthesiol 20

      Pages: 180-187

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新しい診断と治療のABC 132008

    • Author(s)
      飯田真美
    • Journal Title

      『脂質異常症(高脂血症)』脂質異常症(高脂血症)の管理・治療(3)禁煙指導(山下静也編集)(最新医学社) 第4章

      Pages: 225-233

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Part.5心臓病の初発・再発防止とリハビリテーション、どうすれば禁煙は可能か(禁煙による初発・再発予防)2008

    • Author(s)
      飯田真美、藤原久義
    • Journal Title

      『心臓病のすべて』からだの科学 257

      Pages: 186-190

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生活習慣と脂質異常症、喫煙と脂質異常症『脂質異常症の臨床ガイドラインの日常診療への応用』2008

    • Author(s)
      飯田真美、鷹津久登、田中孜
    • Journal Title

      モダンフィジシャン 28

      Pages: 367-372

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 『心血管疾患診療のエクセレンス』心血管疾患患者への生活指導のテクニック2008

    • Author(s)
      飯田真美、藤原久義
    • Journal Title

      禁煙指導日本医師会雑誌特別号 137

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特集/ライフスタイルは心血管不全にどう関与するのか2008

    • Author(s)
      飯田真美
    • Journal Title

      喫煙と心血管不全Life Style Medicine 2

      Pages: 118-125

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特集『たばこ研究』たばこ対策の推進に向けた保健医療専門学会の取り組み2008

    • Author(s)
      飯田真美、藤原久義
    • Journal Title

      公衆衛生 72

      Pages: 560-564

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特大号「日常臨床に活かす診療ガイドライン」禁煙ガイドライン(2005)2008

    • Author(s)
      飯田真美、藤原久義
    • Journal Title

      診断と治療 96

      Pages: 1958-1965

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特集・各科領域における禁煙治療の実際禁煙治療薬と保険診療2008

    • Author(s)
      飯田真美
    • Journal Title

      医薬ジャーナル 44

      Pages: 73-77

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特集禁煙を科学する治療・禁煙支援の実際「禁煙ガイドラインと保険診療」2008

    • Author(s)
      飯田真美
    • Journal Title

      綜合臨牀 57

      Pages: 2119-2123

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] インピーダンス脈波を利用した血管内皮機能測定阻血解除前後の脈波波形解析2008

    • Author(s)
      近藤正之, 横田康成, 飯田真美, 飯田宏樹, 森田浩之, 宇野嘉弘
    • Journal Title

      電子情報通信学会技術研究報告(MEとバイオサイバネティックス) 108

      Pages: 5-8

    • NAID

      110007114129

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase inhibitor and nicolinamide adenine dinucleatide phos phate oxidase inhibitor prevent impairment of endothelium-depen dent cerebral vaisodilation by acute cigarette smiking in ratsl2008

    • Author(s)
      lida H, lida M, et al
    • Journal Title

      J Renin Angjocensin Aldosterone Syst 9(2)

      Pages: 89-94

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative smoking cessation and smoke-free policy in a university hospital injapan2008

    • Author(s)
      lida H, lida M, et al
    • Journal Title

      1. Can J Anaesth 55(5)

      Pages: 316-318

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of transient cerebral ischemia on vasopressin-induced vasoconstrictioniin rabbit corebral vessels.2008

    • Author(s)
      Kumazawa M, lida II, Uchida M, lida M, et al.
    • Journal Title

      Anesth Analg 106(3)

      Pages: 910-915

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] The effects of varenicline associated with acute smoking on the endothelial function in cerebral vessels in rats2010

    • Author(s)
      Iida M, Iida H, Takenaka M, Tanabe K.
    • Organizer
      American Society of Anesthesiologist 2010 Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Preconditioning with estrogen improves the deterioration of PsptO2 after aortic cross-clamping2010

    • Author(s)
      Takenaka M, Iida H, Iida M.
    • Organizer
      American Society of Anesthesiologist 2010 Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-10-16
    • Related Report
      2010 Final Research Report
  • [Presentation] The effects of varenicline associated with acute smoking on the endothelial function in cerebral vessels in rats2010

    • Author(s)
      Iida, M, et al.
    • Organizer
      ASAAnnual Meeting 2010
    • Place of Presentation
      San Diego,米国
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳脊髄循環からみた中枢神経保護2009

    • Author(s)
      飯田宏樹
    • Organizer
      日本臨床麻酔学会第29回大会
    • Place of Presentation
      浜松
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Remote preconditioning could prevent the deterioration of spinal cord PtO2 during aortic cross-clamp.2009

    • Author(s)
      Takenaka M, Iida H, Iida M, Dohi S.
    • Organizer
      American Society of Anesthesiologist 2009 Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2009-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Comparative effects of cilostazol and aspirin on the impairment of endothelium-dependent cerebral vasodilation caused by acute cigarette smoking in rats.2009

    • Author(s)
      Iida M, Iida H, Takenaka M, Fukuoka N, Dohi S.
    • Organizer
      American Society of Anesthesiologist 2009 Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2009-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Remote preconditioning could prevent the deterioration of spinal cord PtO2 during aortic cross-clamp.2008

    • Author(s)
      Takenaka M, Iida H, Iida M, Dohi S.
    • Organizer
      American Society of Anesthesiologist 2008 Annual Meeting
    • Place of Presentation
      Orland, USA
    • Year and Date
      2008-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Remote pieconditioning could prevel the deterioration of spinal cord Pt02 during aortic cross-clamp.2008

    • Author(s)
      Takenaka M, lida H, lida M, Dohi S.
    • Organizer
      American Society of Anesthesiologist 2008 Annual Meeting.
    • Place of Presentation
      Orland. USA
    • Year and Date
      2008-10-21
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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