Internalization profiles of dimerized opioid receptors ; Implication for the mechanism of tolerance
| Project/Area Number |
20591834
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
HOJO Minoru Nagasaki University, 医歯薬学総合研究科, 助教 (00380957)
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| Co-Investigator(Kenkyū-buntansha) |
UEZONO Yasuhito 国立がんセンター研究所, がん患者病態生理研究部, 部長 (20213340)
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| Co-Investigator(Renkei-kenkyūsha) |
SORA Ichirou 東北大学, 医学研究科, 教授 (40322713)
TAKADA Masafumi 長崎大学, 医歯薬総合研究科, 助教 (00404244)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 疼痛管理学 / オピオイド / 二量体 / 疼痛 / 耐性 / 共焦点レーザー顕微鏡 / FRET / モルヒネ / internalization / オピオイド受容体 / 二量体化オピオイド受容体 / 電気生理学 / FRETアッセイ / オピオイド鎮痛薬 |
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| Research Abstract |
We demonstrated distinct recycling profiles of μ-δ OR heterodimer by each opioid in addition to distinct internalization and recycling profiles by each opioid.
These result suggest that the differences in internalization and recycling profiles of the μ-δ OR heterodimer may in part of explain the distinct tolerance of each opioid.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Possible involvement of β-endorphin in a loss of the coordinated balance of μ-opioid receptors trafficking processes by fentanyl.2011
Author(s)
Imai S, Sudo Y, Nakamura A, Ozeki A, Asato M, Hojo M, Devi LA, Kuzumaki N, Suzuki T, Uezono Y, Narita M
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Journal Title
Related Report
Peer Reviewed
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